DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ulp1 and Senp1

DIOPT Version :9

Sequence 1:	NP_573362.1	Gene:	Ulp1 / 32910	FlyBaseID:	FBgn0027603	Length:	1513	Species:	Drosophila melanogaster
Sequence 2:	XP_038936284.1	Gene:	Senp1 / 300193	RGDID:	1310275	Length:	724	Species:	Rattus norvegicus

Alignment Length:	791	Identity:	204/791 - (25%)
Similarity:	320/791 - (40%)	Gaps:	206/791 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   831 KRDLQEDISMGLEILKKIRGMLSGWYSSRESETDSTDTGTGFQAQNGKGFGAGRQPENSFLSQKR 895
            ||...||.:.|:::                      |.|......:...|.|...|.:.|...:.
  Rat    29 KRPEMEDTADGVKM----------------------DAGEVTLVNHSSAFRAHLLPHSGFPEDQL 71

  Fly   896 RNQEENPRLIKYRRVDNSFPRLITNETAEDLI-PN-----------NSMAKRDQPQSSKRLSIFN 948
            ...::  :::.:|:  .:..|..|..|:.... |:           :...||..|.|...|...:
  Rat    72 ALSDQ--QILPFRQ--GTLHRAFTGSTSSAAYNPDYHSGFFVSKMRSPPLKRHNPSSDSFLGSGD 132

  Fly   949 PPVYTQH---RVRNDAPHVPTPFDDEESSQRL-ANAGPSSRPM----TYSDAVRLGHNGISESRV 1005
            ...:.|.   :.||..|...:......:|:.| .....:||..    ..:|:..|.:..:.:|..
  Rat   133 IRTFGQSANGQWRNSTPASGSALQKPRNSRSLYLETRKTSRCRILWNRVTDSCGLSNTFVGKSNH 197

  Fly  1006 NGH-----SSHTVRREPS-----RLHRSILSHEMNCKDQEQY----NELIRTQTNYVGSRYLKPG 1056
            :.|     .|..::..||     ...||:||.:   |.|.::    .|.::.:...:..:.|:..
  Rat   198 HCHVSAYEKSFPIKPAPSPSWSGSCRRSLLSPK---KTQRRHFSTAEETVQEEEKEIYRQLLQMV 259

  Fly  1057 TPPTFQRAKAQS---ATSSSCSLQDNQSNITDSFPSPHGRANPELTEYAKLINRQENEENRSPAP 1118
            |...|..||..:   ...|.| |..|::::.||.
  Rat   260 TGKQFSVAKPTTHFPLHLSRC-LSSNKNSLKDSL------------------------------- 292

  Fly  1119 QQPKRNASNSSASH--ASTISSSASSSCSTCSTCSSSDTEPMLVKDSPEV--------------- 1166
               .|| .||.|||  .|..|||.|:|..|... ..|.:...|:..:|:|
  Rat   293 ---LRN-GNSCASHVIGSDTSSSGSASILTAQE-QLSHSAHSLISGTPDVAFGSKDSALHHHLSA 352

  Fly  1167 -------KEANEANEANEANEANETKENDAPQPTTTRIKKP----------------DFLHRRFA 1208
                   ..:|..:|.:::....:.||:..|   .:|...|                |.|.   :
  Rat   353 PHQPDSLPASNPQSEGSDSVILLKVKESQTP---ASRYLSPLKRSTCPYIIPYSAVTDLLS---S 411

  Fly  1209 NCIFLRNDF-------AENFKARANRRQLESMHLLGIAEQQANESKDERLAYEKKLREVMFRSGA 1266
            :..|.:.:.       ..:.:||...||:|....|.:..|.....:.|....:..  |:..|.
  Rat   412 SPTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEQEHAVLDSV--ELHLRV-- 472

  Fly  1267 PHRPFFEIGPLEQPEEKKETKLIPLT------KEDHA------RFQEMT-TIEVTTNLIFK---- 1314
                     |||        |.:|:|      |:.|.      .|.|:| .:|.....:|:
  Rat   473 ---------PLE--------KEVPVTAAQETRKKSHQLTDSEDEFPEITEEMEKEIKNVFRNGNQ 520

  Fly  1315 -------YNLQITTDDIFTFVDGEWLNDAIINFYMSMLTERSEKRAGELPATYAMNTFFMPRLLQ 1372
                   :.|.||..||.|.....||||.||||||:||.|||:::.  .|:.:|.||||..:|..
  Rat   521 DEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKG--FPSVHAFNTFFFTKLKA 583

  Fly  1373 AGYAGVRRWTRKVDLFSKDIIPVPVHCGNVHWCMAIIHLRNKTIFYYDSMGRPNQPALDALVKYL 1437
            |||..|:|||:|||:||.||:.||:|.| ||||:|::..|.|::.||||||..|..|...|::||
  Rat   584 AGYQAVKRWTKKVDVFSVDILLVPIHLG-VHWCLAVVDFRKKSVTYYDSMGGVNNEACRILLQYL 647

  Fly  1438 HEESLDKRKQPFDMTGFVV--ENAQNIPRQGNSSDCGVFSCMFAEYITRDVPITFSQAEMLYFRT 1500
            .:||:||:::.||..|:.:  :.:|.||:|.|.||||:|:|.:|:.||:|.||.|:|..|.|||.
  Rat   648 KQESVDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRK 712

  Fly  1501 KMALEIADGKL 1511
            :|..||...||
  Rat   713 RMVWEILHRKL 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ulp1	NP_573362.1	Ehrlichia_rpt	200..>580	CDD:118064
Ulp1	NP_573362.1	Peptidase_C48	1331..1506	CDD:280975	89/176 (51%)
Senp1	XP_038936284.1	mukB	<433..>527	CDD:235316	23/114 (20%)
Senp1	XP_038936284.1	Peptidase_C48	<500..722	CDD:420019	102/224 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	189	1.000	Domainoid score	I3195
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1480705at2759
OrthoFinder	1	1.000	-	-		FOG0000698
OrthoInspector	1	1.000	-	-		mtm8978
orthoMCL	1	0.900	-	-		OOG6_101235
Panther	1	1.100	-	-	LDO	PTHR12606
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.780