DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ulp1 and SENP1

DIOPT Version :9

Sequence 1:	NP_573362.1	Gene:	Ulp1 / 32910	FlyBaseID:	FBgn0027603	Length:	1513	Species:	Drosophila melanogaster
Sequence 2:	XP_016874718.1	Gene:	SENP1 / 29843	HGNCID:	17927	Length:	707	Species:	Homo sapiens

Alignment Length:	871	Identity:	221/871 - (25%)
Similarity:	332/871 - (38%)	Gaps:	243/871 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   716 PLPPAEAQPGSTSEDISDPVSPEHWEQLESLDPSTICIRKTFNLIRDISESLVADPEQPEAEAHR 780
            ||......|||:                    |..:||           .:.|:|.::.|.|...
Human     4 PLTATICLPGSS--------------------PPGLCI-----------FAKVSDVKRLEMETRF 37

  Fly   781 KSIFLLRQKLADVCHKVLTEIIHGRATDEIISILR------EILEQTKEIPPRPTPKRDLQED-I 838
            ..|.....:|....|...:.......||:|...:|      .::...........|:....|| :
Human    38 CLISQAGLELLGSSHSSASASQSASITDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQL 102

  Fly   839 SMG-LEILKKIRGMLS--------------GWYS---SRESETDSTDTGTGFQAQNGKGFGAGRQ 885
            |:. .:||...:|.|.              .:||   |.:|...|.|..|..|:.||:  .....
Human   103 SLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQ--WRNST 165

  Fly   886 PENSFLSQKRRNQEENPRLIKYRRVDNSFPRLITNETAEDLIPNNSMAKRDQPQSSKRLSIFNPP 950
            |.:|...||.||...     .|         |.|.:|:..|  :||.|.:
Human   166 PSSSSSLQKSRNSRS-----LY---------LETRKTSSGL--SNSFAGK--------------- 199

  Fly   951 VYTQHRVRNDA-----PHVPTPFDDEESSQRLANAGPSSRPMTYSDAVRLGHNGISESRVNGHSS 1010
              :.|.....|     |..|.|......|.|.:...|..                ::.|....:.
Human   200 --SNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKK----------------TQRRHVSTAE 246

  Fly  1011 HTVRREPSRLHRSILS------------------HEMNCKDQEQYNELIRTQTNYVGSRYLKPGT 1057
            .||:.|...::|.:|.                  |...|         :.:..|.:.....|.|.
Human   247 ETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRC---------LSSSKNTLKDSLFKNGN 302

  Fly  1058 PPTFQRAKAQSATSSSCSLQDNQSNITDSFPSPHGRANPELTEYAKLINRQENEENRSPAPQQPK 1122
            ....|...:.:::|.|.|:..||..::.|..| .....|::...:|......:..:....|.||.
Human   303 SCASQIIGSDTSSSGSASILTNQEQLSHSVYS-LSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPD 366

  Fly  1123 RNASNSSASHASTISSSASSSCSTCSTCSSSDTEPMLVKDSPEVKEANEANEANEANEANETKEN 1187
            ..|::::.|                   ..||:..:|                       :.|::
Human   367 NLAASNTQS-------------------EGSDSVILL-----------------------KVKDS 389

  Fly  1188 DAPQPTTTRIKKPDFLHRRFANCIFLRNDFAENFKARANRRQLESMHLLGIAEQQANESKDERL- 1251
            ..|.|::|..:...::....:         ..:.:||...||:|....|.:  |..|:...||.
Human   390 QTPTPSSTFFQAELWIKELTS---------VYDSRARERLRQIEEQKALAL--QLQNQRLQEREH 443

  Fly  1252 ----AYEKKLREVMFRSGAPHRPFFEIGPLE--------QPEEKKETKLIPLTKEDHARFQEMT- 1303
                :.|..||.                |||        |..:||..||  ...||  .|.|:|
Human   444 SVHDSVELHLRV----------------PLEKEIPVTVVQETQKKGHKL--TDSED--EFPEITE 488

  Fly  1304 TIEVTTNLIFK-----------YNLQITTDDIFTFVDGEWLNDAIINFYMSMLTERSEKRAGELP 1357
            .:|.....:|:           :.|.||..||.|.....||||.||||||:||.|||:::.  ||
Human   489 EMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKG--LP 551

  Fly  1358 ATYAMNTFFMPRLLQAGYAGVRRWTRKVDLFSKDIIPVPVHCGNVHWCMAIIHLRNKTIFYYDSM 1422
            :.:|.||||..:|..|||..|:|||:|||:||.||:.||:|.| ||||:|::..|.|.|.|||||
Human   552 SVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLG-VHWCLAVVDFRKKNITYYDSM 615

  Fly  1423 GRPNQPALDALVKYLHEESLDKRKQPFDMTGFVV--ENAQNIPRQGNSSDCGVFSCMFAEYITRD 1485
            |..|..|...|::||.:||:||:::.||..|:.:  :.:|.||:|.|.||||:|:|.:|:.||:|
Human   616 GGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKD 680

  Fly  1486 VPITFSQAEMLYFRTKMALEIADGKL 1511
            .||.|:|..|.|||.:|..||...||
Human   681 RPINFTQQHMPYFRKRMVWEILHRKL 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ulp1	NP_573362.1	Ehrlichia_rpt	200..>580	CDD:118064
Ulp1	NP_573362.1	Peptidase_C48	1331..1506	CDD:280975	91/176 (52%)
SENP1	XP_016874718.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I3244
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1480705at2759
OrthoFinder	1	1.000	-	-		FOG0000698
OrthoInspector	1	1.000	-	-		mtm8505
orthoMCL	1	0.900	-	-		OOG6_101235
Panther	1	1.100	-	-	LDO	PTHR12606
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.780