DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ulp1 and Semp2l2b

DIOPT Version :9

Sequence 1:	NP_573362.1	Gene:	Ulp1 / 32910	FlyBaseID:	FBgn0027603	Length:	1513	Species:	Drosophila melanogaster
Sequence 2:	NP_444494.1	Gene:	Semp2l2b / 114671	MGIID:	2149738	Length:	495	Species:	Mus musculus

Alignment Length:	571	Identity:	151/571 - (26%)
Similarity:	236/571 - (41%)	Gaps:	149/571 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   998 NGISESR------VNGHSSHTVRREPSRLHRSILSHEMNCKDQEQYNELIRTQTNYVGSRYLKPG 1056
            :||.:.|      |....|..:.:||.|          .|:|.             .|..:.:||
Mouse    16 SGIGQKRKYHDESVTEIESEPLGQEPKR----------KCQDG-------------TGMVFKEPG 57

  Fly  1057 TPPTFQR-----------AKAQSATSSSCS-LQDNQSN----ITDSFPSPHGRA----------- 1094
            ..|..|.           .|.|..|..... |:..:.:    :|...|:..|:.
Mouse    58 KEPRDQELPREHPSKGQVRKPQGKTPKQLEPLELTEGSPEQVVTGRKPADGGKGHKRPYSVMEEN 122

  Fly  1095 --NPELTEYAKLINRQENEENRSPAPQQPKRNASNSSASHASTISSSASSSCSTCSTCSSSDTEP 1157
              :|:..:|.:|:...:.:::.|..|.:|....:|:..      .....|..|..|..:.||.||
Mouse   123 EQSPQKEKYGRLLQHLQCDQDVSSDPHRPHPFLTNTWK------IKGGESEDSRGSERTQSDREP 181

  Fly  1158 MLV---KD--SPEVKE--ANEANEANEANEA--NETKENDAPQPTTTRIKKPDFLHRRFANCIFL 1213
            ..|   |:  |||.:|  .:|.....|..:.  .|.:..::.:|.....:....|.....|.:|
Mouse   182 STVVALKECLSPEEREKCCSEEKCVTEKKDCIKGEGRRGNSLEPDLPGTQAQIILDSGKGNSLF- 245

  Fly  1214 RNDFAENFKARANRRQLESMHLLGIAEQQANESKDERLAYEKKLREVMFRSGAPHRPFFEIGP-- 1276
                                           .:|...||.|||             |..:.|.
Mouse   246 -------------------------------PNKVAVLAAEKK-------------PITDRGKGR 266

  Fly  1277 --------LEQPEEKKETKLIPLTKEDHARFQEMTTIEVTTNLIFKYNLQITTDDIFTFVDGEWL 1333
                    .|..|::.|..|.|..:|           |:.::   ::.|||:..||.|..:|:||
Mouse   267 EMDQILDITEDMEKEIENALGPGPQE-----------EILSS---RFKLQISRGDIQTLENGQWL 317

  Fly  1334 NDAIINFYMSMLTERSEKRAGELPATYAMNTFFMPRLLQAGYAGVRRWTRKVDLFSKDIIPVPVH 1398
            ||.:|||||::|.||:|.:.  .||.:..:|||.|:|...||:.|:||||.::||.|::|.||:|
Mouse   318 NDEVINFYMNLLVERNENQG--YPALHVFSTFFYPKLKHGGYSSVKRWTRGINLFEKELILVPIH 380

  Fly  1399 CGNVHWCMAIIHLRNKTIFYYDSMGRPNQPALDALVKYLHEESLDKRK---QPFDMTGFVVENAQ 1460
             ..|||.:.:|.||.::|.|.||||:..:...:.:.:||..||..:|.   .|.:...:.| .::
Mouse   381 -QRVHWSLVVIDLRKRSIVYLDSMGQTGKSICETIFQYLQNESKTRRNVELDPLEWKQYSV-TSE 443

  Fly  1461 NIPRQGNSSDCGVFSCMFAEYITRDVPITFSQAEMLYFRTKMALEIADGKL 1511
            .||.|.|.||||:|:|.:|:||.||.|:||||..|..||.:|..||...:|
Mouse   444 EIPLQLNGSDCGMFTCKYADYIARDQPVTFSQQHMPTFRKRMVWEILHSQL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ulp1	NP_573362.1	Ehrlichia_rpt	200..>580	CDD:118064
Ulp1	NP_573362.1	Peptidase_C48	1331..1506	CDD:280975	77/177 (44%)
Semp2l2b	NP_444494.1	Peptidase_C48	<272..490	CDD:304959	92/235 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836051
Domainoid	1	1.000	189	1.000	Domainoid score	I3284
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1480705at2759
OrthoFinder	1	1.000	-	-		FOG0000698
OrthoInspector	1	1.000	-	-		mtm8739
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12606
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5705
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.840