DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HSD11B2 and CG8888

DIOPT Version :9

Sequence 1:	NP_000187.3	Gene:	HSD11B2 / 3291	HGNCID:	5209	Length:	405	Species:	Homo sapiens
Sequence 2:	NP_610724.1	Gene:	CG8888 / 36293	FlyBaseID:	FBgn0033679	Length:	388	Species:	Drosophila melanogaster

Alignment Length:	371	Identity:	105/371 - (28%)
Similarity:	157/371 - (42%)	Gaps:	62/371 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    29 RLGRPLL----AALA---LLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARP-----QRLPVA 81
            ||..|.|    ||:.   ||.|||         .::::..|...|.||:.:...     .::..:
  Fly    39 RLFMPFLFCQAAAIVTSHLLHALD---------ISSISTFAVFVWFALATVGAVLFYHFVKVSAS 94

Human    82 TRAVLITGCDSGFGKETAKKLDSMGFTVLA---TVLELNSPGAIELRTCCSPRLRLLQMDLTKPG 143
            .:.||||||::......|||||.:||||.|   |.:|.:....| |:...|.|::||.:|:|...
  Fly    95 GKGVLITGCEAPLAWYLAKKLDDLGFTVYAGFNTPIEESDEAKI-LKEVTSGRMKLLHLDVTSEK 158

Human   144 DISRVLEFTKAHTT--STGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPL 206
            .|.....:...|..  :.|||.:|:.| |...:.:.|..|.|..|..:::|..|:..||:..|||
  Fly   159 TILEAARYVSQHLPHGAEGLWSVVHCA-HWIALGELEWIPFAVLRKSLDLNLLGSARLTQIFLPL 222

Human   207 LRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCF------ 265
            :|.:.||:|.:.|....:|.|..|....::|||.........|:...||.||::..|.|
  Fly   223 VRRAHGRVVFLTSGLNRVPSPVRGIQCATQAAVDCFAACLRQEMRTRGVDVSVVAAGEFAPGNGW 287

Human   266 --KTESVRNVGQ-WEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITD 327
              :||......| |.:        |..|..:.||:||.|..........|.| :|:.|.:..:.|
  Fly   288 LNETELRDQAKQMWNQ--------LSSEQKKTYGEDYYEAAMTSVEKYSRQA-ADIQPTLRVLID 343

Human   328 ALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLP 373
            |:....|..||.|             :....|   ||.|...|..|
  Fly   344 AVTRTFPMARYTP-------------VTSSER---LQIFLAEHLAP 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSD11B2	NP_000187.3	type2_17beta_HSD-like_SDR_c	83..363	CDD:187665	85/293 (29%)
		Essential for protein stability	335..339		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..405
CG8888	NP_610724.1	NADB_Rossmann	96..380	CDD:304358	90/305 (30%)
CG8888	NP_610724.1	adh_short	96..293	CDD:278532	64/198 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1610
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D370032at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1882
SonicParanoid	1	1.000	-	-		X110
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850