DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mec2 and STOML1

DIOPT Version :9

Sequence 1:	NP_573357.1	Gene:	Mec2 / 32905	FlyBaseID:	FBgn0030993	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_004800.2	Gene:	STOML1 / 9399	HGNCID:	14560	Length:	398	Species:	Homo sapiens

Alignment Length:	324	Identity:	88/324 - (27%)
Similarity:	151/324 - (46%)	Gaps:	59/324 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 MGAAGMAPEPALRVPGTTQQYRGFKTSENEPKGCM---------------EW-------VVTLFS 73
            :|.:|....|........|...||..|:   |||:               .|       :::...
Human     2 LGRSGYRALPLGDFDRFQQSSFGFLGSQ---KGCLSPERGGVGTGADVPQSWPSCLCHGLISFLG 63

  Fly    74 VLIFIITSPIAIFICFKVVAEYERAIIFRLGRLSGGARGPGMFFILPCIDEYRKVDLRTVTFNVP 138
            .|:.::|.||:.:...|:|..|||.|:|||||:. ..:||||..:||.||.:::|||||..||||
Human    64 FLLLLVTFPISGWFALKIVPTYERMIVFRLGRIR-TPQGPGMVLLLPFIDSFQRVDLRTRAFNVP 127

  Fly   139 QQEMLTKDSVTVTVDAVVYYRISDPLYAVIQVEDYSMSTRLLAATTLRNIVGTRNLSELLTERET 203
            ..::.:||...::|.|.|.:||.||:.:|:.|:|.:.:||:.|...:...:..|.|.|:..|:..
Human   128 PCKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLKRPLREIQMEKLK 192

  Fly   204 LAHNMQATLDEATEPWGVMVERVEIKDVSLPVSMQRAMAAEAEAARDARAKVIAAE---GEKKS- 264
            ::..:...:::.|..||:.|:|||:   ::...:|....:.|....|:..:.:|..   |...|
Human   193 ISDQLLLEINDVTRAWGLEVDRVEL---AVEAVLQPPQDSPAGPNLDSTLQQLALHFLGGSMNSM 254

  Fly   265 ---------ATALKEASDVISASPSALQLRYLQTLSSISAEKNSTIIFPLPMELLT---PYLAK 316
                     |..::..|:|...:|.         :.:.|:.|.     ||...|||   |:|::
Human   255 AGGAPSPGPADTVEMVSEVEPPAPQ---------VGARSSPKQ-----PLAEGLLTALQPFLSE 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mec2	NP_573357.1	PHB	88..238	CDD:214581	54/149 (36%)
Mec2	NP_573357.1	SPFH_like	107..314	CDD:302763	61/222 (27%)
STOML1	NP_004800.2	Tyrosine-type lysosomal sorting signal. /evidence=ECO:0000255, ECO:0000269\|PubMed:19696025	6..10		1/3 (33%)
		PHB	77..217	CDD:214581	53/140 (38%)
		SPFH_SLP-1	94..224	CDD:259814	45/133 (34%)
		SCP2	304..395	CDD:280250	0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062075at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820