Protein Alignment Mec2 and STOML1

DIOPT Version :10

• Sequence 1: NP_573357.1
• Gene: Mec2 / 32905
• FlyBaseID: FBgn0030993
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_004800.2
• Gene: STOML1 / 9399
• HGNCID: 14560
• Length: 398
• Species: Homo sapiens
• Alignment Length: 324
• Identity: 88/324 - (27%)
• Similarity: 151/324 - (46%)
• Gaps: 59/324 - (18%)

  Fly    31 MGAAGMAPEPALRVPGTTQQYRGFKTSENEPKGCM---------------EW-------VVTLFS 73
            :|.:|....|........|...||..|:   |||:               .|       :::...
Human     2 LGRSGYRALPLGDFDRFQQSSFGFLGSQ---KGCLSPERGGVGTGADVPQSWPSCLCHGLISFLG 63

  Fly    74 VLIFIITSPIAIFICFKVVAEYERAIIFRLGRLSGGARGPGMFFILPCIDEYRKVDLRTVTFNVP 138
            .|:.::|.||:.:...|:|..|||.|:|||||:. ..:||||..:||.||.:::|||||..||||
Human    64 FLLLLVTFPISGWFALKIVPTYERMIVFRLGRIR-TPQGPGMVLLLPFIDSFQRVDLRTRAFNVP 127

  Fly   139 QQEMLTKDSVTVTVDAVVYYRISDPLYAVIQVEDYSMSTRLLAATTLRNIVGTRNLSELLTERET 203
            ..::.:||...::|.|.|.:||.||:.:|:.|:|.:.:||:.|...:...:..|.|.|:..|:..
Human   128 PCKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLKRPLREIQMEKLK 192

  Fly   204 LAHNMQATLDEATEPWGVMVERVEIKDVSLPVSMQRAMAAEAEAARDARAKVIAAE---GEKKS- 264
            ::..:...:::.|..||:.|:|||:   ::...:|....:.|....|:..:.:|..   |...|
Human   193 ISDQLLLEINDVTRAWGLEVDRVEL---AVEAVLQPPQDSPAGPNLDSTLQQLALHFLGGSMNSM 254

  Fly   265 ---------ATALKEASDVISASPSALQLRYLQTLSSISAEKNSTIIFPLPMELLT---PYLAK 316
                     |..::..|:|...:|.         :.:.|:.|.     ||...|||   |:|::
Human   255 AGGAPSPGPADTVEMVSEVEPPAPQ---------VGARSSPKQ-----PLAEGLLTALQPFLSE 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mec2	NP_573357.1	SPFH_like	107..314	CDD:473137	61/222 (27%)
STOML1	NP_004800.2	Tyrosine-type lysosomal sorting signal. /evidence=ECO:0000255, ECO:0000269|PubMed:19696025	6..10		1/3 (33%)
		SPFH_SLP-1	94..224	CDD:259814	45/133 (34%)
		SCP2	311..395	CDD:460423