Protein Alignment Mec2 and PHB2

DIOPT Version :10

• Sequence 1: NP_573357.1
• Gene: Mec2 / 32905
• FlyBaseID: FBgn0030993
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_011747.2
• Gene: PHB2 / 853146
• SGDID: S000003463
• Length: 310
• Species: Saccharomyces cerevisiae
• Alignment Length: 294
• Identity: 72/294 - (24%)
• Similarity: 120/294 - (40%)
• Gaps: 60/294 - (20%)

  Fly    43 RVPGTTQQY-------------RGFKTSENEPKGCMEWVVTLFSVLIFIITSPIAIFI---CFKV 91
            |.||..|:|             .|.:.....|:|....:..|      ::....|:||   .|.|
Yeast     3 RSPGEFQRYAKAFQKQLSKVQQTGGRGQVPSPRGAFAGLGGL------LLLGGGALFINNALFNV 61

  Fly    92 VAEYERAIIF-RLGRLSGGARGPGMFFILPCIDEYRKVDLRTVTFNVPQQEMLTKDSVTVTVDAV 155
            ...: |||:: |:..:|......|..||.|.:|.....|:|....||..... |||...|.:...
Yeast    62 DGGH-RAIVYSRIHGVSSRIFNEGTHFIFPWLDTPIIYDVRAKPRNVASLTG-TKDLQMVNITCR 124

  Fly   156 VYYRISDPLYAVIQV--------EDYSMSTRLLAA---TTLRNIVGTRNLSELLTERETLAHNMQ 209
            |   :|.|  .|:|:        :||  ..|:|.:   ..|:.:|...|.|:|:|:||.::..::
Yeast   125 V---LSRP--DVVQLPTIYRTLGQDY--DERVLPSIVNEVLKAVVAQFNASQLITQREKVSRLIR 182

  Fly   210 ATLDEATEPWGVMVERVEIKDVSLPVSMQRAMAAEAEAARDA--------------RAKVIAAEG 260
            ..|......:.::::.|.|..::.......|:.|:..|.:||              :..|:.|:|
Yeast   183 ENLVRRASKFNILLDDVSITYMTFSPEFTNAVEAKQIAQQDAQRAAFVVDKARQEKQGMVVRAQG 247

  Fly   261 EKKSATALKEASDVISASPSALQLRYLQTLSSIS 294
            |.|||..:.||   |..|...::|:.|.|...|:
Yeast   248 EAKSAELIGEA---IKKSRDYVELKRLDTARDIA 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mec2	NP_573357.1	SPFH_like	107..314	CDD:473137	54/213 (25%)
PHB2	NP_011747.2	SPFH_prohibitin	58..252	CDD:259799	50/202 (25%)