Protein Alignment Mec2 and PHB1

DIOPT Version :10

• Sequence 1: NP_573357.1
• Gene: Mec2 / 32905
• FlyBaseID: FBgn0030993
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_011648.3
• Gene: PHB1 / 853033
• SGDID: S000003364
• Length: 287
• Species: Saccharomyces cerevisiae
• Alignment Length: 288
• Identity: 71/288 - (24%)
• Similarity: 120/288 - (41%)
• Gaps: 47/288 - (16%)

  Fly    75 LIFIITS---PIAIFICFKVVAEYE-----RAIIF-RLGRLSGGARGPGMFFILPCIDEYRKVDL 130
            ||.:||.   ||.|.......:.|:     |.:|| |:..:.....|.|..|::|.:.:....|:
Yeast     7 LIDVITKVALPIGIIASGIQYSMYDVKGGSRGVIFDRINGVKQQVVGEGTHFLVPWLQKAIIYDV 71

  Fly   131 RTVTFNVPQQEMLTKDSVTVTVDAVVYYRISDP----LYAVIQVEDYSMSTRLLAA---TTLRNI 188
            ||...::..... |||...|::...|.:|   |    |.|:.|........|:|.:   ..|::|
Yeast    72 RTKPKSIATNTG-TKDLQMVSLTLRVLHR---PEVLQLPAIYQNLGLDYDERVLPSIGNEVLKSI 132

  Fly   189 VGTRNLSELLTERETLAHNMQATLDEATEPWGVMVERVEIKDVSLPVSMQRAMAAEAEAARDA-- 251
            |...:.:||:|:||.::..::..|......:|:.:|.|.|..::......:|:..:..|.:||
Yeast   133 VAQFDAAELITQREIISQKIRKELSTRANEFGIKLEDVSITHMTFGPEFTKAVEQKQIAQQDAER 197

  Fly   252 ------------RAKVIAAEGEKKSATALKEASDVISASPSALQLRYLQTLSSISAE-KNSTIIF 303
                        :|.||.||||.:||..:.:|  :.......|.:|.|:....|:.. .||:.:.
Yeast   198 AKFLVEKAEQERQASVIRAEGEAESAEFISKA--LAKVGDGLLLIRRLEASKDIAQTLANSSNVV 260

  Fly   304 PLPMELLTPYLAKYAHLMGPPPELKQSP 331
            .||.:          |..|...|...||
Yeast   261 YLPSQ----------HSGGGNSESSGSP 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mec2	NP_573357.1	SPFH_like	107..314	CDD:473137	54/228 (24%)
PHB1	NP_011648.3	SPFH_prohibitin	29..223	CDD:259799	48/197 (24%)