Protein Alignment Mec2 and NPHS2

DIOPT Version :10

• Sequence 1: NP_573357.1
• Gene: Mec2 / 32905
• FlyBaseID: FBgn0030993
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_055440.1
• Gene: NPHS2 / 7827
• HGNCID: 13394
• Length: 383
• Species: Homo sapiens
• Alignment Length: 352
• Identity: 139/352 - (39%)
• Similarity: 204/352 - (57%)
• Gaps: 36/352 - (10%)

  Fly    17 RNSGPASSTAYMVNMGAAGMAPEPALRVPGTT----QQYRGFKTSENE---------PK------ 62
            :.:||..|     ..|.||...||  |.|..|    .:.||......|         |:
Human    39 QEAGPEPS-----GSGRAGTPGEP--RAPAATVVDVDEVRGSGEEGTEVVALLESERPEEGTKSS 96

  Fly    63 --GCMEWVVTLFSVLIFIITSPIAIFICFKVVAEYERAIIFRLGR-LSGGARGPGMFFILPCIDE 124
              |..||::.|.|:|..|:|.|.:|:.|.|||.||||.||||||. |.|.|:|||:||.|||:|.
Human    97 GLGACEWLLVLISLLFIIMTFPFSIWFCVKVVQEYERVIIFRLGHLLPGRAKGPGLFFFLPCLDT 161

  Fly   125 YRKVDLRTVTFNVPQQEMLTKDSVTVTVDAVVYYRISDPLYAVIQVEDYSMSTRLLAATTLRNIV 189
            |.|||||..|..:|..|::|||...:.:||:.|||:.:....:..:...|.:.:.|..||::.::
Human   162 YHKVDLRLQTLEIPFHEIVTKDMFIMEIDAICYYRMENASLLLSSLAHVSKAVQFLVQTTMKRLL 226

  Fly   190 GTRNLSELLTERETLAHNMQATLDEATEPWGVMVERVEIKDVSLPVSMQRAMAAEAEAARDARAK 254
            ..|:|:|:|.||:::|.:.:..||..|..||:.|||:|||||.||..:|.::|.||||.|.|:.:
Human   227 AHRSLTEILLERKSIAQDAKVALDSVTCIWGIKVERIEIKDVRLPAGLQHSLAVEAEAQRQAKVR 291

  Fly   255 VIAAEGEKKSATALKEASDVISASPSALQLRYLQTLSSISAEKNSTIIFPLPMELL----TPYLA 315
            :||||.||.::.:|:.|::::|.:|:|:|||||.||.|:|.||.||::.|||.:||    :|...
Human   292 MIAAEAEKAASESLRMAAEILSGTPAAVQLRYLHTLQSLSTEKPSTVVLPLPFDLLNCLSSPSNR 356

  Fly   316 KYAHLMGPPPEL---KQSPEKSDNIVL 339
            ....|..|.|..   ..:|:|.|:.:|
Human   357 TQGSLPFPSPSKPVEPLNPKKKDSPML 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mec2	NP_573357.1	SPFH_like	107..314	CDD:473137	92/210 (44%)
NPHS2	NP_055440.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..76		13/43 (30%)
		SPFH_podocin	122..344	CDD:259809	103/221 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..383		6/27 (22%)