DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mec2 and Stoml1

DIOPT Version :9

Sequence 1:	NP_573357.1	Gene:	Mec2 / 32905	FlyBaseID:	FBgn0030993	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_081218.3	Gene:	Stoml1 / 69106	MGIID:	1916356	Length:	399	Species:	Mus musculus

Alignment Length:	252	Identity:	76/252 - (30%)
Similarity:	130/252 - (51%)	Gaps:	19/252 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 MAPEPALRVPGTTQQYRGFKTSENEPKGCMEWVVTLFSVLIFIITSPIAIFICFKVVAEYERAII 100
            ::|||....||.       ...|:.|......:|::...|:.::|.||:.:...|:|..|||.|:
Mouse    33 LSPEPGSVGPGA-------DAPESWPSCLCHGLVSVLGFLLLLLTFPISGWFALKIVPTYERMIV 90

  Fly   101 FRLGRLSGGARGPGMFFILPCIDEYRKVDLRTVTFNVPQQEMLTKDSVTVTVDAVVYYRISDPLY 165
            |||||:. ..:||||..:||.||.:::|||||..||||..::.:||...::|.|.|.:||.||:.
Mouse    91 FRLGRIR-NPQGPGMVLLLPFIDSFQRVDLRTRAFNVPPCKLASKDGAVLSVGADVQFRIWDPVL 154

  Fly   166 AVIQVEDYSMSTRLLAATTLRNIVGTRNLSELLTERETLAHNMQATLDEATEPWGVMVERVEIKD 230
            :|:.|:|.:.:||:.|...:...:..|.|.|:..|:..:...:...:::.|..||:.|:|||:
Mouse   155 SVMAVKDLNTATRMTAHNAMTKALLRRPLQEIQMEKLKIGDQLLLEINDVTRAWGLEVDRVEL-- 217

  Fly   231 VSLPVSMQRAMAAEAEAARDARAKVIAAE---GEKKSATALKEASDVISASPSALQL 284
             ::...:|....:....:.|:..:.:|..   |...||     ...|.|..|..|::
Mouse   218 -AVEAVLQPPQDSLTVPSLDSTLQQLALHLLGGSMNSA-----VGHVPSPGPDTLEM 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mec2	NP_573357.1	PHB	88..238	CDD:214581	54/149 (36%)
Mec2	NP_573357.1	SPFH_like	107..314	CDD:302763	53/181 (29%)
Stoml1	NP_081218.3	Tyrosine-type lysosomal sorting signal. /evidence=ECO:0000250\|UniProtKB:Q9UBI4, ECO:0000255	6..10
		PHB	77..217	CDD:214581	53/140 (38%)
		SPFH_SLP-1	94..224	CDD:259814	45/133 (34%)
		SCP2	305..396	CDD:280250
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062075at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820