Protein Alignment Mec2 and PHB1

DIOPT Version :10

• Sequence 1: NP_573357.1
• Gene: Mec2 / 32905
• FlyBaseID: FBgn0030993
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_002625.1
• Gene: PHB1 / 5245
• HGNCID: 8912
• Length: 272
• Species: Homo sapiens
• Alignment Length: 244
• Identity: 62/244 - (25%)
• Similarity: 113/244 - (46%)
• Gaps: 41/244 - (16%)

  Fly    97 RAIIF-RLGRLSGGARGPGMFFILPCIDEYRKVDLRTVTFNVPQQEMLT--KDSVTVTVDAVVYY 158
            ||:|| |...:.....|.|..|::|.:.:....|.|:...|||   ::|  ||...|.:...:.:
Human    35 RAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVP---VITGSKDLQNVNITLRILF 96

  Fly   159 R-ISDPLYAVIQV--EDYSMSTRLLAATT---LRNIVGTRNLSELLTERETLAHNMQATLDEATE 217
            | ::..|..:...  |||  ..|:|.:.|   |:::|...:..||:|:||.::..:...|.|...
Human    97 RPVASQLPRIFTSIGEDY--DERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAA 159

  Fly   218 PWGVMVERVEI------KDVSLPVSMQRAMAAEAEAAR--------DARAKVIAAEGEKKSATAL 268
            .:|::::.|.:      |:.:..|..::....|||.||        ..:|.:|:|||:.|:|..:
Human   160 TFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELI 224

  Fly   269 KEASDVISASPSALQLRYLQTLSSI----SAEKNST-------IIFPLP 306
              |:.:.:|....::||.|:....|    |..:|.|       ::..||
Human   225 --ANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVLLQLP 271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mec2	NP_573357.1	SPFH_like	107..314	CDD:473137	57/233 (24%)
PHB1	NP_002625.1	SPFH_prohibitin	27..221	CDD:259799	50/190 (26%)