Protein Alignment Mec2 and Nphs2

DIOPT Version :10

• Sequence 1: NP_573357.1
• Gene: Mec2 / 32905
• FlyBaseID: FBgn0030993
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_570841.3
• Gene: Nphs2 / 170672
• RGDID: 620461
• Length: 383
• Species: Rattus norvegicus
• Alignment Length: 347
• Identity: 130/347 - (37%)
• Similarity: 203/347 - (58%)
• Gaps: 27/347 - (7%)

  Fly     2 EPHQ-DSPVYANYEDMRNSGPASSTAYMVNMGAAGMAPEPALRVPGTTQQYRGFKTSENEPKGCM 65
            |.|: .:....|.:::|:.|...:....:   .....||..::..|.               |..
  Rat    55 EEHRAPAATVVNVDEVRSPGEEGTEVVAL---LESERPEEGIKPSGL---------------GAC 101

  Fly    66 EWVVTLFSVLIFIITSPIAIFICFKVVAEYERAIIFRLGR-LSGGARGPGMFFILPCIDEYRKVD 129
            ||::.|.|::..|:|.|.:|:.|.|||.||||.||||||. |.|.|:|||:||.|||:|.|.|||
  Rat   102 EWLLVLSSLIFIIVTFPFSIWFCIKVVQEYERVIIFRLGHLLPGRAKGPGLFFFLPCLDTYHKVD 166

  Fly   130 LRTVTFNVPQQEMLTKDSVTVTVDAVVYYRISDPLYAVIQVEDYSMSTRLLAATTLRNIVGTRNL 194
            ||..|..:|..|::|||...:.:|||.|||:.:....:..:...|.:.:.|..||::.::..|:|
  Rat   167 LRLQTLEIPFHEVVTKDMFIMEIDAVCYYRMENASLLLSSLAHVSKAIQFLVQTTMKRLLAHRSL 231

  Fly   195 SELLTERETLAHNMQATLDEATEPWGVMVERVEIKDVSLPVSMQRAMAAEAEAARDARAKVIAAE 259
            :|:|.||:::|.:::..||..|..||:.|||.|||||.||..:|.::|.||||.|.|:.:|||||
  Rat   232 TEILLERKSIAQDVKVALDSVTCVWGIKVERTEIKDVRLPAGLQHSLAVEAEAQRQAKVRVIAAE 296

  Fly   260 GEKKSATALKEASDVISASPSALQLRYLQTLSSISAEKNSTIIFPLPMELLTPYLAKYAHLMG-- 322
            |||.::.:|:.|::::|.:|:|:|||||.||.|:|.:|.||::.|||.::|....:......|
  Rat   297 GEKAASESLRMAAEILSGTPAAVQLRYLHTLQSLSTDKPSTVVLPLPFDMLNLLSSPSNRAQGSI 361

  Fly   323 -----PPPELKQSPEKSDNIVL 339
                 |.|....:|::.|:.:|
  Rat   362 NYPSSPKPVEPLNPKRKDSPML 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mec2	NP_573357.1	SPFH_like	107..314	CDD:473137	92/206 (45%)
Nphs2	NP_570841.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..73		4/17 (24%)
		SPFH_podocin	122..344	CDD:259809	105/221 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..383		5/27 (19%)