Protein Alignment Mec2 and Nphs2

DIOPT Version :10

• Sequence 1: NP_573357.1
• Gene: Mec2 / 32905
• FlyBaseID: FBgn0030993
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_569723.1
• Gene: Nphs2 / 170484
• MGIID: 2157018
• Length: 385
• Species: Mus musculus
• Alignment Length: 336
• Identity: 132/336 - (39%)
• Similarity: 201/336 - (59%)
• Gaps: 30/336 - (8%)

  Fly    23 SSTAYMVNMGAAGMAPEPALRVPGTTQQYR---GFKTSENEPKGCMEWVVTLFSVLIFIITSPIA 84
            ::||.:|::.......|....|....:..|   |.|.|   ..|..||::.|.|::..|:|.|.:
Mouse    61 AATATVVDVDEVRGPGEEGTEVVALLESERPEEGIKPS---GLGACEWLLVLASLIFIIMTFPFS 122

  Fly    85 IFICFKVVAEYERAIIFRLGR-LSGGARGPGMFFILPCIDEYRKVDLRTVTFNVPQQEMLTKDSV 148
            |:.|.|||.||||.||||||. |.|.|:|||:||.|||:|.|.|||||..|..:|..|::|||..
Mouse   123 IWFCIKVVQEYERVIIFRLGHLLPGRAKGPGLFFFLPCLDTYHKVDLRLQTLEIPFHEVVTKDMF 187

  Fly   149 TVTVDAVVYYRISDPLYAVIQVEDYSMSTRLLAATTLRNIVGTRNLSELLTERETLAHNMQATLD 213
            .:.:|||.|||:.:....:..:...|.:.:.|..||::.::..|:|:|:|.||:::|.:::..||
Mouse   188 IMEIDAVCYYRMENASLLLSSLAHVSKAIQFLVQTTMKRLLAHRSLTEILLERKSIAQDVKVALD 252

  Fly   214 EATEPWGVMVERVEIKDVSLPVSMQRAMAAEAEAARDARAKVIAAEGEKKSATALKEASDVISAS 278
            ..|..||:.|||.|||||.||..:|.::|.||||.|.|:.:||||||||.::.:|:.|::::|.:
Mouse   253 AVTCIWGIKVERTEIKDVRLPAGLQHSLAVEAEAQRQAKVRVIAAEGEKAASESLRMAAEILSGT 317

  Fly   279 PSALQLRYLQTLSSISAEKNSTIIFPLPMELLTPYLAKYAHLMGPPPELKQ-------------- 329
            |:|:|||||.||.|:|.||.:|::.|||.::|:        |:..|....|
Mouse   318 PAAVQLRYLHTLQSLSTEKPATVVLPLPFDMLS--------LLSSPGNRAQGSINYPSSSKPVEP 374

  Fly   330 -SPEKSDNIVL 339
             :|:|.|:.:|
Mouse   375 LNPKKKDSPML 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mec2	NP_573357.1	SPFH_like	107..314	CDD:473137	92/206 (45%)
Nphs2	NP_569723.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..64		0/2 (0%)
		SPFH_podocin	124..346	CDD:259809	105/221 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..385		4/27 (15%)