Protein Alignment Mec2 and Stom

DIOPT Version :10

• Sequence 1: NP_573357.1
• Gene: Mec2 / 32905
• FlyBaseID: FBgn0030993
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_038543.1
• Gene: Stom / 13830
• MGIID: 95403
• Length: 284
• Species: Mus musculus
• Alignment Length: 269
• Identity: 163/269 - (60%)
• Similarity: 211/269 - (78%)
• Gaps: 7/269 - (2%)

  Fly    43 RVPGTTQQYRGFKTSENEPKGCMEWVVTLFSVLIFIITSPIAIFICFKVVAEYERAIIFRLGR-L 106
            |:|      ..|:.:.....|...|::...|....|||.||:|:||.|:|.||||.||||||| |
Mouse    14 RIP------ESFRENSKTELGACGWILVAASFFFVIITFPISIWICIKIVKEYERVIIFRLGRIL 72

  Fly   107 SGGARGPGMFFILPCIDEYRKVDLRTVTFNVPQQEMLTKDSVTVTVDAVVYYRISDPLYAVIQVE 171
            .|||:|||:||||||.|...|||:||::|::|.||:|||||||::||.|||||:.:...||..:.
Mouse    73 QGGAKGPGLFFILPCTDSLIKVDMRTISFDIPPQEVLTKDSVTISVDGVVYYRVQNATLAVANIT 137

  Fly   172 DYSMSTRLLAATTLRNIVGTRNLSELLTERETLAHNMQATLDEATEPWGVMVERVEIKDVSLPVS 236
            :...:|||||.|||||.:||:|||::|::||.:||:||:|||:||:.||:.|||||||||.|||.
Mouse   138 NADSATRLLAQTTLRNALGTKNLSQILSDREEIAHHMQSTLDDATDDWGIKVERVEIKDVKLPVQ 202

  Fly   237 MQRAMAAEAEAARDARAKVIAAEGEKKSATALKEASDVISASPSALQLRYLQTLSSISAEKNSTI 301
            :||||||||||||:|||||||||||..::.||||||.||:.||:||||||||||::|:|||||||
Mouse   203 LQRAMAAEAEAAREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKNSTI 267

  Fly   302 IFPLPMELL 310
            :||||:::|
Mouse   268 VFPLPVDML 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mec2	NP_573357.1	SPFH_like	107..314	CDD:473137	135/204 (66%)
Stom	NP_038543.1	SPFH_stomatin	73..274	CDD:259801	134/200 (67%)
		Required for homooligomerization. /evidence=ECO:0000250	265..273		6/7 (86%)
		Required for lipid raft association. /evidence=ECO:0000250	267..269		1/1 (100%)
		Interaction with LANCL1. /evidence=ECO:0000250	273..284		1/4 (25%)