Protein Alignment BIRC2 and Diap2

DIOPT Version :10

• Sequence 1: NP_001157.1
• Gene: BIRC2 / 329
• HGNCID: 590
• Length: 618
• Species: Homo sapiens
• Sequence 2: NP_477127.1
• Gene: Diap2 / 36748
• FlyBaseID: FBgn0015247
• Length: 498
• Species: Drosophila melanogaster
• Alignment Length: 590
• Identity: 182/590 - (30%)
• Similarity: 269/590 - (45%)
• Gaps: 117/590 - (19%)

Human    46 ELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSC 110
            |..|::|:..:|...|||...|...||:.||...:.:|..|.:.:|.|:.||...::|::..|.|
  Fly     9 ESVRLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAERHRRSSPIC 73

Human   111 SFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTN 175
            |.:  |.....|:..:                           |..|.|..||  |.|...|.:.
  Fly    74 SMV--LAPNHCGNVPR---------------------------SQESDNEGNS--VVDSPESCSC 107

Human   176 PYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEH 240
            |   .:..|..|.:|:..||...::|..||:|||||:...|.|.|..|.|.::.||..|:|..||
  Fly   108 P---DLLLEANRLVTFKDWPNPNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAFEEH 169

Human   241 RRHFPNCPFLE----------NSLETLRFSISNLSMQTH----AARMRTFMYWPSSVPVQP-EQL 290
            :|.||.||.::          .:|:.|....:.|.::..    .||:|||..||.| .:|| ..|
  Fly   170 KRFFPQCPRVQMGPLIEFATGKNLDELGIQPTTLPLRPKYACVDARLRTFTDWPIS-NIQPASAL 233

Human   291 ASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHL 355
            |.||.||....|.|:||.|:.|||.|:..|:||.|||||.|:|:|::..||..:|.|:
  Fly   234 AQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPWFEHAKWSPKCQFVLLAKGPAYVSEV------- 291

Human   356 LEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTT 420
                |:|  |....::.|..   .|..:...|.:|...| .|.||.:|.:..:|:..:|.|:|::
  Fly   292 ----LAT--TAANASSQPAT---APAPTLQADVLMDEAP-AKEALALGIDGGVVRNAIQRKLLSS 346

Human   421 GENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKA 485
            |..:.|:::::..:.:........|..:..|..|    ..|...:....:..:..:|:.|:
  Fly   347 GCAFSTLDELLHDIFDDAGAGAALEVREPPEPSA----PFIEPCQATTSKAASVPIPVADS---- 403

Human   486 NVINKQEHDIIKQKTQIPL--QARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYI 548
                            ||.  ||.|          |.|||.|              ..|:..|..
  Fly   404 ----------------IPAKPQAAE----------AVANISK--------------ITDEIQKMS 428

Human   549 PTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTV 613
            .......|||||:.|:|::.|.||||:|:||.|||:|||||..|.:||||:..||:||..|||.|
  Fly   429 VATPNGNLSLEEENRQLKDARLCKVCLDEEVGVVFLPCGHLATCNQCAPSVANCPMCRADIKGFV 493

Human   614 RTFLS 618
            |||||
  Fly   494 RTFLS 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BIRC2	NP_001157.1	BIR 1	46..113		22/66 (33%)
		BIR	49..115	CDD:237989	21/65 (32%)
		BIR	183..252	CDD:197595	29/78 (37%)
		BIR 2	184..250		29/65 (45%)
		BIR	268..336	CDD:197595	35/72 (49%)
		BIR 3	269..336		35/71 (49%)
		UBA_BIRC2_3	391..437	CDD:270577	11/45 (24%)
		CARD_BIRC2_BIRC3	453..544	CDD:260038	15/92 (16%)
		RING-HC_BIRC2_3_7	562..618	CDD:438373	34/55 (62%)
Diap2	NP_477127.1	BIR	12..78	CDD:237989	21/67 (31%)
		BIR	112..181	CDD:197595	29/68 (43%)
		BIR	213..281	CDD:237989	36/68 (53%)
		UBA_IAPs	320..363	CDD:270506	11/43 (26%)
		RING-HC_BIRC2_3_7	442..498	CDD:438373	34/55 (62%)