Protein Alignment RhoGAP18B and ARHGAP32

DIOPT Version :9

• Sequence 1: NP_573352.2
• Gene: RhoGAP18B / 32898
• FlyBaseID: FBgn0261461
• Length: 1317
• Species: Drosophila melanogaster
• Sequence 2: NP_001364953.1
• Gene: ARHGAP32 / 9743
• HGNCID: 17399
• Length: 2101
• Species: Homo sapiens
• Alignment Length: 682
• Identity: 136/682 - (19%)
• Similarity: 245/682 - (35%)
• Gaps: 218/682 - (31%)

  Fly   722 IIEALPVEGEDEEDE---------DEEDDDVDD-----EEEDLGDYDESLPS---DAD----PDV 765
            ||:....|.|:.|::         .||||.|.:     ...:..|::|:|.:   .||    |..
Human    23 IIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGD 87

  Fly   766 MALQAAAVFAAGVRHKLSTSTLTKRSKMMMPTP----------LP------SPTASMDHGAWETD 814
            :.|:...          ||:::..:......||          ||      ...|...|..:| :
Human    88 LTLKTCG----------STASMKVKHVKKSTTPGLMGCDNIHRLPFTKGHFPKMAECAHFHYE-N 141

  Fly   815 MEFMYSRES-KEEADETLSLGSTVTNSTATLGSISSTGSSVTGQPKDTPKDLPADQQPSVVVHPI 878
            :||...:.| .||.:|.:..|.. :.....|..|:..|.|
Human   142 VEFGSIQLSLSEEQNEVMKNGCE-SKELVYLVQIACQGKS------------------------- 180

  Fly   879 LRNICIFYSQKDPKKYSAIFYDYHLSLVHQRFMTRIRRPAPPPPAQLATSNTTSLAPRSDDSGCS 943
                  :..::..:.:..:....||.:..:||            :||      |..||||
Human   181 ------WIVKRSYEDFRVLDKHLHLCIYDRRF------------SQL------SELPRSD----- 216

  Fly   944 CEAEDSYNHQHNPTPAIPKPLKEEWERAVLAAGAVAGKRGVAPRTGRKLRVRSNARLLLTDSVLA 1008
             ..:||           |:.:.:.....:....|:||.:                  :.....|.
Human   217 -TLKDS-----------PESVTQMLMAYLSRLSAIAGNK------------------INCGPALT 251

  Fly  1009 WRETLQDVN--CCEDEEDMIVPVTDILRAQQIQEDNEVQQTQQSTILQRYK-------SVSIGNL 1064
            |.|.....|  ...:|..:..|...                 .:.:::||.       ::.:|::
Human   252 WMEIDNKGNHLLVHEESSINTPAVG-----------------AAHVIKRYTARAPDELTLEVGDI 299

  Fly  1065 ---LDLPGEDDKKSIKNRMRMKFAVNSNVF------RINR-----------SPKSEK-------- 1101
               :|:|    .|.:....|.|......:|      .||:           .|.|:|
Human   300 VSVIDMP----PKVLSTWWRGKHGFQVGLFPGHCVELINQKVPQSVTNSVPKPVSKKHGKLITFL 360

  Fly  1102 ----KSRSRRGQVNSLYLDEQKYPLFAAPLSALELNMTDHPNVPRFVVDVCAYIEQPECIEQDGL 1162
                |||..:.::....:.:::  :|...|....||  ....||:.:....|:||:...:  ||:
Human   361 RTFMKSRPTKQKLKQRGILKER--VFGCDLGEHLLN--SGFEVPQVLQSCTAFIERYGIV--DGI 419

  Fly  1163 YRASGNKVLVDELRKKLTHVYDPRWLK---TDDIHTLTSLHKQFFRELTSPLITQEAYERLGRSL 1224
            ||.||....:..||.:....:.|...|   ..|||::.||.|.:||||.:||:|.:.||:...::
Human   420 YRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAV 484

  Fly  1225 N---DDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQI 1286
            :   |:..:.::......:|.|:..||.||:|||:.:|...:...|.:.||||||.|.||.:.||
Human   485 SAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQI 549

  Fly  1287 Q----------LDIGRMNMLAKVLIENYDRIF 1308
            :          :::...:::.:.::.:.|.:|
Human   550 ESACFSGTAAFMEVRIQSVVVEFILNHVDVLF 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	52/163 (32%)
ARHGAP32	NP_001364953.1	PX_RICS	141..255	CDD:132831	30/198 (15%)
		SH3_ARHGAP32_33	277..330	CDD:212769	9/56 (16%)
		RhoGAP_CdGAP	382..576	CDD:239849	57/199 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	832..872
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	941..1052
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1117..1157
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1183..1271
		Interaction with GAB2. /evidence=ECO:0000269|PubMed:12819203	1405..1725
		Interaction with FYN. /evidence=ECO:0000269|PubMed:12788081	1699..2101
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1812..1910

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810