DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP18B and ARHGAP12

DIOPT Version :9

Sequence 1:	NP_573352.2	Gene:	RhoGAP18B / 32898	FlyBaseID:	FBgn0261461	Length:	1317	Species:	Drosophila melanogaster
Sequence 2:	NP_060757.4	Gene:	ARHGAP12 / 94134	HGNCID:	16348	Length:	846	Species:	Homo sapiens

Alignment Length:	894	Identity:	188/894 - (21%)
Similarity:	324/894 - (36%)	Gaps:	278/894 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   524 STRRRGTAIVREEGVCGGESSTSSNNSKKNNNNNSNNNSGALMAAPKPNGEAERPSTNSNNNTIN 588
            |:..:||.::|:                      :|.|.|              ||.| ...|:|
Human   120 SSSVQGTGLIRD----------------------ANQNFG--------------PSYN-QGQTVN 147

  Fly   589 CSSNNNNDNISNNNNNHHTVDNESGINNNKNNDGNANCNVNEQQQQQQQQPITQNCVIKVRRPAP 653
            .|.:..::|...||::|                                              :|
Human   148 LSLDLTHNNGKFNNDSH----------------------------------------------SP 166

  Fly   654 KVPVRNPNTSLSN---PRQIEEEQTKPNGGKKDNLRGNSFAAENSSPEEQE-EESIYQPIWQFKT 714
            ||..:|...|..:   |..::.|:|             ||:.|.|.....| .|.|:|
Human   167 KVSSQNRTRSFGHFPGPEFLDVEKT-------------SFSQEQSCDSAGEGSERIHQ------- 211

  Fly   715 IEPVDQEIIEALPVEGEDEEDEDEEDDDVDDEEEDLGDYDESLPSDADPDVMALQAAAVFAAGVR 779
                             |.|..||......::..     ..:.|:...||      :.|:|....
Human   212 -----------------DSESGDELSSSSTEQIR-----ATTPPNQGRPD------SPVYANLQE 248

  Fly   780 HKLSTSTLTKRSKMMMPTPLPSPTASMDHGAWETDME-----FMYSRESKEEA--------DETL 831
            .|:|.|.|         .|||...|...:|.|||..:     :.|:|.::|..        |.::
Human   249 LKISQSAL---------PPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTRDASI 304

  Fly   832 SLG-----------STVTNSTATLGSISSTGSSVTGQPKDTPKDLPADQQPSVVVHPI------- 878
            |.|           |:..|..:|  |.|.:.|.....|:...::|  |::.    |.:
Human   305 SKGDFQNPGDQELLSSEENYYST--SYSQSDSQCGSPPRGWSEEL--DERG----HTLYTSDYTN 361

  Fly   879 ---LRNI----CIFYSQKDPKKYSAIFYDYHLSLVHQRFMTRIR---RPAPPPPAQLATSNTTSL 933
               |:::    ..:|...|..:.......|:.|...||.:.:.|   |....|.......::|.:
Human   362 EKWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIV 426

  Fly   934 APRSDDSG------CSCEAEDS-YNHQHNPTPAIPKPLKEEWERAVLAAGAVAGKRGVAPRTGRK 991
            ...:|...      |..|.|.| .:.:|..|.:.|   |::.:..:|....:|       ..|:|
Human   427 LDTNDKESPTASKPCFPENESSPSSPKHQDTASSP---KDQEKYGLLNVTKIA-------ENGKK 481

  Fly   992 LR--------VRSNARLLLT---DSVLAWRETLQD------------VNCCEDEEDMIVPVTDIL 1033
            :|        |...:.||.|   .|..:|..:.|.            :.....::.....|.: |
Human   482 VRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSSKKNVFE-L 545

  Fly  1034 RAQQ-----IQEDNEVQ-----QTQQSTILQRYKSVSIG---NLLDLPG---EDDKKSIKNRMRM 1082
            :.:|     ||.||:..     :...|||..:......|   .:.|.||   .|.:|..|:..::
Human   546 KTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDSPGIEKHDKEKEQKDPKKL 610

  Fly  1083 K-FAVNS-NVFRINRSPKSEKKSRSRRGQVNSL----YLDEQKYPLFAAPLSALELNMTDHPNVP 1141
            : |.|:| :.....::.|:.||..:||..:.::    |:.:|   :|.:.|:  .|...::..||
Human   611 RSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQ---VFGSNLA--NLCQRENGTVP 670

  Fly  1142 RFVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLTH-----VYDPRWLKTDDIHTLTSLHK 1201
            :||.....::|: ..::.||:||.|||..::.:||..:.|     :.|.:|   :|||.:|...|
Human   671 KFVKLCIEHVEE-HGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKW---EDIHVITGALK 731

  Fly  1202 QFFRELTSPLITQEAYERLGRSLNDDAAIERMSLAFD---DMPEPNRSTLRFLIRHLTRVAAASA 1263
            .|||||..||.|...:.....::..:.. :|::...|   .:|:||:.|::.|.|||.||.....
Human   732 MFFRELPEPLFTFNHFNDFVNAIKQEPR-QRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGE 795

  Fly  1264 SNRMPSTNLAIVWGPCLL----SANQIQLDIGRMNMLAKVLIENYDRIF 1308
            .|||...::|||:||.||    ....|.:.....|.:.::::.....||
Human   796 KNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIF 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	52/159 (33%)
ARHGAP12	NP_060757.4	SH3-WW_linker	71..266	CDD:293224	50/285 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..241		27/182 (15%)
		WW	268..298	CDD:238122	7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..316		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..466		9/40 (23%)
		PH_ARHGAP9-like	465..576	CDD:270053	22/118 (19%)
		PH	479..574	CDD:278594	18/95 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	580..629		10/48 (21%)
		RhoGAP_ARHGAP27_15_12_9	654..839	CDD:239868	57/191 (30%)
		SH3_ARHGAP12	15..74	CDD:213003
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000816
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010