Protein Alignment RhoGAP18B and BEM3

DIOPT Version :9

• Sequence 1: NP_573352.2
• Gene: RhoGAP18B / 32898
• FlyBaseID: FBgn0261461
• Length: 1317
• Species: Drosophila melanogaster
• Sequence 2: NP_015210.1
• Gene: BEM3 / 855988
• SGDID: S000006036
• Length: 1128
• Species: Saccharomyces cerevisiae
• Alignment Length: 1264
• Identity: 229/1264 - (18%)
• Similarity: 416/1264 - (32%)
• Gaps: 438/1264 - (34%)

  Fly   270 GSSSLYLNESICQWMTSLRRQVHHYDEGPWQQPKSVPARDPSSSAEESTVTLRRSTEESAKCADE 334
            ||::|.|........:...:.:.|.::|.....:..|:.|...:   ..:.|:...:|.....:.
Yeast    11 GSTTLELLAQYNDHRSKKDKSIEHIEKGTCSGKERNPSYDEIFT---ENIKLKLQVQEYETEIES 72

  Fly   335 QAKLVKDFKRKLQQKRAHNVEPEREQRRCAITANFVND---YLSALGEEKEAVQHQQVAAIEEHV 396
            ..|::.    .||:.|..::|...||.:.....::|||   .|.....|::|           |:
Yeast    73 LEKVID----MLQKNREASLEVVLEQVQNDSRDSYVNDQSFVLPPRSAERKA-----------HI 122

  Fly   397 AVVAIAIQPQVSVSLLRLMQSLALSASLHVSVRGFLTAYDKSFSLWLWHQQQQQRQQPPINGYRR 461
            ..:.:.| |.:|.. |:....:||..|:..:|.......:.|.|                    |
Yeast   123 KSLNLPI-PTLSPP-LQQGSDVALETSVTPTVPQIGVTSNTSIS--------------------R 165

  Fly   462 RRARDSVVGVVGDWRRRLPLFAFSFAGGNDRSVASASVSVSPAISESV---------DVCAAAAS 517
            :..::.::                    ||...|::|.|....|:.||         .:.:.|||
Yeast   166 KHLQNMIL--------------------NDEIEANSSFSSPKIINRSVSSPTKIHSEQLASPAAS 210

  Fly   518 -----------------------RRRANRSTRRRGTAIVREEGVCGGESSTSSN-----NSK--- 551
                                   |.|:.::..|. ||::........::|||:|     .||
Yeast   211 VTYTTSRITIKSPNKGSKSPLQERLRSPQNPNRM-TAVINNHLHSPLKASTSNNLDELTESKSQQ 274

  Fly   552 -------KNNNNNSNNNSGA------LMAAPKPN------------------------------- 572
                   ||:...|:..|.|      ..||..|:
Yeast   275 LTNDAIQKNDRVYSSITSSAYTTGTPTSAAKSPSSLLEVKEGENKALGFSPASKEKLDDFTQLLD 339

  Fly   573 ---GEAERPSTNSNN-----NTINCS-----------SNNNNDNISNNN--NNHHTVDNESGINN 616
               ||.:..:|:|.:     :|||.|           |..::.||.|:.  ::|..    |.:..
Yeast   340 SSFGEEDLVNTDSKDPLSIKSTINESLPPPPAPPTFFSPTSSGNIKNSTPLSSHLA----SPVIL 400

  Fly   617 NKNNDGNANCNVNEQQQQQQQQPITQNCVIKVRRPAPKVPVRNPNTSLSNPRQIEEEQTKPNGGK 681
            ||.:|     |...|..:..::|:..:.:..:   :.|:...:.|.||.....:|....:...|:
Yeast   401 NKKDD-----NFGAQSAKNLKKPVLTSSLPNL---STKLSTTSQNASLPPNPPVESSSKQKQLGE 457

  Fly   682 KDNLRGNSFAAENSSPEEQEEESIYQP-IWQFKTIEPVDQEIIEALPVEGEDEE----------- 734
            ..::...:.....||..:...:::.:| .....|::.|.|.:...:|:..:.|:
Yeast   458 TASIHSTNTLNTFSSTPQGSLKTLRRPHASSVSTVKSVAQSLKSDIPLFVQPEDFGTIQIEVLST 522

  Fly   735 -DEDEEDD--------DVDDEEE------------DLGDYDES----LPSDADPDVMALQA---- 770
             ..|.|||        |....:|            :|..|.:|    ||....||....|.
Yeast   523 LYRDNEDDLSILIAIIDRKSGKEMFKFSKSIHKVRELDVYMKSHVPDLPLPTLPDRQLFQTLSPT 587

  Fly   771 -------------AAVFAA---------GVRHKLSTSTL---------TKRSKMMMPTP---LPS 801
                         .::|:.         .:...:||.|:         .|...:::..|   ..:
Yeast   588 KVDTRKNILNQYYTSIFSVPEFPKNVGLKIAQFISTDTVMTPPMMDDNVKDGSLLLRRPKTLTGN 652

  Fly   802 PTASMDHGAWETDMEFMYSRESKEEADETLSLGSTVTNSTATLGSISSTGSSVTGQPKDTPKD-- 864
            .|..:.:|....|:..::   .|.:..||:.|..                ||:...| :.|:|
Yeast   653 STWRVRYGILRDDVLQLF---DKNQLTETIKLRQ----------------SSIELIP-NLPEDRF 697

  Fly   865 ------LPADQQPSVVVHPILRNICIFYSQKDPKKYSAIFYDYHLSLVHQRFMTRIRRPAPPPPA 923
                  |..:.:.|.:.......||. .:.|:.:.:.:.|.||
Yeast   698 GTRNGFLITEHKKSGLSTSTKYYICT-ETSKERELWLSAFSDY---------------------- 739

  Fly   924 QLATSNTTSLAPRSDDSGCSCEAEDSYNHQHNPTPAIPKPLKEEWERAVLAAGAVAGKRGVAPRT 988
             :..|.:.||:     |..:....||.:|                    |:||....|.|
Yeast   740 -IDPSQSLSLS-----SSRNANDTDSASH--------------------LSAGTHHSKFG----- 773

  Fly   989 GRKLRVRSNARLLLTDSVLAWRETLQDVNCCEDEEDMIVP--VTDILRAQQIQEDNEVQQTQQS- 1050
                    ||.:..||:                      |  |||:  .|:...:|.:..:..:
Yeast   774 --------NATISATDT----------------------PSYVTDL--TQEYNNNNNISNSSNNI 806

  Fly  1051 ----------TILQRYKSVSIGNLLDLPGEDDKKSIKNRMRMKF----------AVN------SN 1089
                      :....:.:.|.||     .|::|.|.:.:||..|          |:|      ||
Yeast   807 ANSDGIDSNPSSHSNFLASSSGN-----AEEEKDSRRAKMRSLFPFKKLTGPASAMNHIGITISN 866

  Fly  1090 VFRINRSPKSEKKSRSRR-----GQVNSLYLDEQKYPLFAAPL-SALELNMTDHPNV---PRFVV 1145
            ......||.|..||.|::     ...||.........:|.:.| :.|.|:...:.||   |..|.
Yeast   867 DSDSPTSPDSIIKSPSKKLMEVSSSSNSSTGPHVSTAIFGSSLETCLRLSSHKYQNVYDLPSVVY 931

  Fly  1146 DVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLTHVYDP---RW-----LKTDD--------IH 1194
            ....|:.:...|:::|::|.||:..::..|:::....||.   |:     .|.|:        ::
Yeast   932 RCLEYLYKNRGIQEEGIFRLSGSSTVIKTLQERFDKEYDVDLCRYNESIEAKDDEASPSLYIGVN 996

  Fly  1195 TLTSLHKQFFRELTSPLITQEAYERLGRSL--NDDAAIERMSLAFDDM------PEPNRSTLRFL 1251
            |::.|.|.:.|:|...|...|.:....|.:  |.:..:: :||.|.::      |..|.|.:..|
Yeast   997 TVSGLLKLYLRKLPHLLFGDEQFLSFKRVVDENHNNPVQ-ISLGFKELIESGLVPHANLSLMYAL 1060

  Fly  1252 IRHLTRVAAASASNRMPSTNLAIVWGPCL 1280
            ...|.|:...|..|:|...||.||:.|.|
Yeast  1061 FELLVRINENSKFNKMNLRNLCIVFSPTL 1089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	41/164 (25%)
BEM3	NP_015210.1	PX	520..622	CDD:214610	15/101 (15%)
		PH_Bem3	633..741	CDD:270096	22/151 (15%)
		RhoGAP	904..1110	CDD:413382	47/187 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100