Protein Alignment RhoGAP18B and RGD1

DIOPT Version :9

• Sequence 1: NP_573352.2
• Gene: RhoGAP18B / 32898
• FlyBaseID: FBgn0261461
• Length: 1317
• Species: Drosophila melanogaster
• Sequence 2: NP_009819.1
• Gene: RGD1 / 852563
• SGDID: S000000464
• Length: 666
• Species: Saccharomyces cerevisiae
• Alignment Length: 676
• Identity: 131/676 - (19%)
• Similarity: 233/676 - (34%)
• Gaps: 186/676 - (27%)

  Fly   675 TKPNGGKKDNLRGNSFAAENSSPEEQEEESIYQPIWQ----FKTIEPVDQEIIEALPVEGEDEED 735
            ||.....|:|.:.......::....::.:|.|..:.|    .:..:|...:    |.:.|.....
Yeast   138 TKLRKSVKENSKRLEKDVSDAIHSAEKAQSRYNSLCQDWDKLRMTDPTKTK----LTLRGSKTTK 198

  Fly   736 EDEED-----DDVDDEEEDLGDYDESLPSDADPDVMALQAAAVFAAGVRHKLSTSTLTKRSKMMM 795
            |.||:     |:.|.|.:...|:..||                          .:|...:.:..:
Yeast   199 EQEEELLRKIDNADLEYKQKVDHSNSL--------------------------RNTFITKERPRI 237

  Fly   796 PTPLPSPTASMDHGAWETDMEFMYSRESKEEADETLSLGSTVTNSTATLGSISSTGSSVTGQPKD 860
            ...|......:|     |.|.....:.:....:..|:.|.|::...:| .|:.|...||:.:
Yeast   238 VQELKDLILEID-----TAMTIQLQKYTIWTENLVLNTGVTISPLDST-KSMKSFAGSVSNE--- 293

  Fly   861 TPKDLPA--DQQPSVVVHPILRNICIFYSQKDPKKYSAIFYDYHLSLVHQRFMTRIRRPAPP--- 920
              :||.:  ::......|.:|.|          |....:.|..|.|:.|.:     :..:||
Yeast   294 --RDLYSFLNKYNQTGKHSLLIN----------KNLIPVSYKKHPSMNHGQ-----KNKSPPKFA 341

  Fly   921 --------PPAQLATSNTTSLAPRSDDSGCSCEAE-DSYNHQHNPTPAIPKPLKEEWERAVLAAG 976
                    |...::|.|.:.....|.::.....|. :|.....|....:|..:.........|||
Yeast   342 VDPSRNSIPKRMISTHNESPFLSSSSNTAAVPNANLNSATPSLNTNKQLPPTMASSISSTSNAAG 406

  Fly   977 AVAGKRGVAPRTGRKLRVRSNARLLLTDSVLAWRETLQDVNCCEDEEDMIVPVTDILRAQQIQED 1041
            |::                .::.::.:|:..:..:||...|                .:.||.|:
Yeast   407 AMS----------------PSSSIVTSDTTSSITKTLDPGN----------------NSPQIPEE 439

  Fly  1042 NEVQQTQQSTILQRYKSVSIGNLLDLPGEDDKKSIKNRMRMKFAVNSNVFRINRSPKSEKKSRSR 1106
                               :.|.||          .:|.......|:|:      |...:|:
Yeast   440 -------------------LINSLD----------SDRPISHIQTNNNM------PPGVQKN--- 466

  Fly  1107 RGQVNSLYLDEQKYPLFAAPLSAL---ELNMTDHPNVPRFVVDVCAYIEQPECIEQDGLYRASGN 1168
                         :..|..||.:|   |.:|     ||. :|..|.|:.....::|:|:||.|.|
Yeast   467 -------------FKTFGVPLESLIEFEQDM-----VPA-IVRQCIYVIDKFGLDQEGIYRKSAN 512

  Fly  1169 KVLVDELRKKLTHVYDPRWL---------KTDDIHTLTSLHKQFFRELTSPLITQEAYERLGRSL 1224
            .:.|.:|::::..  ||..:         ...||:.:.||.|.||..|...::.:.....:...|
Yeast   513 VLDVSKLKEEIDK--DPANISMILPSKPHSDSDIYLVGSLLKTFFASLPDSVLPKALSSEIKVCL 575

  Fly  1225 NDDAAIERMSLAFD---DMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQI 1286
            ..:....|.:....   ::|:....|||.|:.||.||.|..|.|||....|.|:|||.:..||..
Yeast   576 QIEDPTTRKNFMHGLIYNLPDAQYWTLRALVFHLKRVLAHEAQNRMNLRALCIIWGPTIAPANPD 640

  Fly  1287 QL-DIGRMNMLAKVLIENYDRIFHPD 1311
            .. |:....|..:||:|..|:.|.|:
Yeast   641 DANDVNFQIMAMEVLLEVSDQAFEPE 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	45/160 (28%)
RGD1	NP_009819.1	F-BAR_Rgd1	39..268	CDD:153336	24/164 (15%)
		RhoGAP_fRGD1	470..663	CDD:239863	58/200 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100