DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP18B and RGA2

DIOPT Version :9

Sequence 1:	NP_573352.2	Gene:	RhoGAP18B / 32898	FlyBaseID:	FBgn0261461	Length:	1317	Species:	Drosophila melanogaster
Sequence 2:	NP_010667.1	Gene:	RGA2 / 851985	SGDID:	S000002787	Length:	1009	Species:	Saccharomyces cerevisiae

Alignment Length:	963	Identity:	190/963 - (19%)
Similarity:	332/963 - (34%)	Gaps:	317/963 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   541 GESSTSSNNSKKNNNNNSNNNSGALMAAPKPNGEAERPSTNSNNNTINCSSNNNN---------D 596
            |:|..|:||:..:.|..|:|....|......:.|.:..|.|.||:..|.......         |
Yeast   166 GKSDVSTNNTAISKNLVSSNEDQQLTPQVLVSQERDESSLNDNNDNDNSKDREETSSHARTVSID 230

  Fly   597 NISNNNNNHHT--------VDNESGINN----------------------------NKNNDGNAN 625
            :|.|:...|.:        ||||..||.                            |.|::.|..
Yeast   231 DILNSTLEHDSNSIEEQSLVDNEDYINKMGEDVTYRLLKPQRANRDSIVVKDPRIPNSNSNANRF 295

  Fly   626 CNVNEQQQQQQQQPITQNCVIKVRRPAPKVPVRNPNTSLSNPR------QIEEEQTKPNG----- 679
            .::.::::..:.....:...|.|..|      ||....:::|.      |:.||...|:|
Yeast   296 FSIYDKEETDKDDTDNKENEIIVNTP------RNSTDKITSPLNSPMAVQMNEEVEPPHGLALTL 354

  Fly   680 --GKKDNLRGNSFAAENSSPEEQEEESIYQPIWQFKTIEPVDQEIIEALPVEGEDEEDEDEEDDD 742
              ..|:|.: :|...:.|:.:.....|   ||.:..|:|.........|.:
Yeast   355 SEATKENNK-SSQGIQTSTSKSMNHVS---PITRTDTVEMKTSTSSSTLRL-------------- 401

  Fly   743 VDDEEEDLGDYDESLPSDAD-----------PDVMALQAAAVFAAGVRHKLSTSTLTKRSKMMMP 796
                 .|.|.:  |.|..||           |:....::.::.:....|.|.:.|    |:|:.|
Yeast   402 -----SDNGSF--SRPQTADNLLPHKKVAPSPNKKLSRSFSLKSKNFVHNLKSKT----SEMLDP 455

  Fly   797 TPLPSPTASMD----HGAWETDMEFMYSRESKE--------EADETL------------------ 831
            .. |..:.|:.    |..|.........|:||.        ::|.|:
Yeast   456 KH-PHHSTSIQESDTHSGWGVSSTHTNIRKSKAKKNPVSRGQSDSTIYNTLPQHGNFTVPEFNHK 519

  Fly   832 ----SLGSTV----TNSTAT----LGSISSTGSSVTGQPKDTPKDLPADQQPSVVVHPILRNICI 884
                ||||..    :|.|||    .||.:|:.|.                          .:|.:
Yeast   520 KAQSSLGSISKKQNSNDTATNRRINGSFTSSSSG--------------------------HHIAM 558

  Fly   885 FYSQKDPKKYSAIFYDYHLS--LVHQRFMTRIRRPAPPPPAQLATSNTTSL--------APRSDD 939
            |  :..|.:...:|....||  ..|.|            .:.|.||.:|:.        ...:|:
Yeast   559 F--RTPPLESGPLFKRPSLSSESAHHR------------SSSLQTSRSTNALLEDDSTKVDATDE 609

  Fly   940 SGCSCEAEDSYNHQHNPTPAIPKPLKEEWERAVLAAGAVAGKRGVAPRTGRKLRVRSNARLLLTD 1004
            |..|.| :|.|                                 ....|.|||::  :.|.|...
Yeast   610 SATSLE-KDFY---------------------------------FTELTLRKLKL--DVRELEGT 638

  Fly  1005 SVLAWRETLQDV-NCCEDEEDMIVPVTDILRAQQIQEDNEVQQTQQSTILQRYKSVSIGNLLDLP 1068
            .    ::.|||| |....:|.::..|.::.|    ::|.:...:::|  |::.::::....:..|
Yeast   639 K----KKLLQDVENLRLAKERLLNDVDNLTR----EKDKQSASSRES--LEQKENIATSITVKSP 693

  Fly  1069 --GEDDKKSIKNRM-RMKF------AVNSNVFRI---NRSPKSEKKSRSRRGQ--VNSLYL---- 1115
              ..|.|.||.|.. :.:|      |.:..|..:   .|||.|.....:...|  ::|..|
Yeast   694 SSNSDRKGSISNASPKPRFWKIFSSAKDHQVGDLESQQRSPNSSSGGTTNIAQKEISSPKLIRVH 758

  Fly  1116 DE----QKYPLFAAPL-------------SALELNMTDHPNVPRFVVDVCA-YIEQPEC-IEQDG 1161
            ||    .|.||..:|.             |:|:.......:....::..|. .||:.:. :..:|
Yeast   759 DELPSPGKVPLSPSPKRLDYTPDGSHLYGSSLQARCAYEKSTVPIIIRCCIDRIEKDDIGLNMEG 823

  Fly  1162 LYRASGNKVLVDELRKKL-------THVYDPRW--LKTDDIHTLTSLHKQFFRELTSPLITQEAY 1217
            |||.||::.||:|:..:.       :....|:.  |...|||.:.|:.|::.|:|..|:::...|
Yeast   824 LYRKSGSQTLVEEIENEFAQNNSLHSDTLSPKLNALLNQDIHAVASVLKRYLRKLPDPVLSFSIY 888

  Fly  1218 ERLGRSLNDDAAIERMSL------------------------AFDDMPEPNRSTLRFLIRHLTRV 1258
            :.|...:.::..|||:.|                        .|..:|..::..|:.|..|:.:|
Yeast   889 DALIDLVRNNQLIERLPLNNDKFLDSPQKVTIYEMVLKSLLEIFKILPVEHQEVLKVLAAHIGKV 953

  Fly  1259 AAASASNRMPSTNLAIVWGPCLL---SANQIQLDIGRMNMLAKVLIENYDRIF 1308
            ...|..|.|...||::|:.|.|:   ...:..:|:...|.:.:.::.||..||
Yeast   954 RRCSERNLMNLHNLSLVFAPSLIHDFDGEKDIVDMKERNYIVEFILGNYRDIF 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	42/185 (23%)
RGA2	NP_010667.1	LIM1_Rga	13..67	CDD:188780
		LIM2_Rga	70..123	CDD:188781
		RhoGAP	815..1002	CDD:214618	41/186 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100