Protein Alignment RhoGAP18B and Chn1

DIOPT Version :10

• Sequence 1: NP_573352.2
• Gene: RhoGAP18B / 32898
• FlyBaseID: FBgn0261461
• Length: 1317
• Species: Drosophila melanogaster
• Sequence 2: XP_006234448.1
• Gene: Chn1 / 84030
• RGDID: 620139
• Length: 476
• Species: Rattus norvegicus
• Alignment Length: 455
• Identity: 104/455 - (22%)
• Similarity: 174/455 - (38%)
• Gaps: 102/455 - (22%)

  Fly   934 APRSDDSGCSCEAEDS---YNHQHNPTPAIPKPLKEEWERAV-LAAGAV--------AGKRGVAP 986
            ||......|:||.|:.   |..:.:...:     :||.::.: :|.|:.        .|...:|.
  Rat    44 APHPRRVTCTCEVENRPKYYGREFHGMIS-----REETDQLLSVAEGSYLIRESQRQPGTYTLAL 103

  Fly   987 RTGRKLRVRSNARLLLTDSVLAWRETLQDVNCCEDEEDMIVPVTDILRAQQIQEDNEVQQTQQST 1051
            |.|.:.|   |.||..........:..:.::      |:   |||.|....| |....:...:.|
  Rat   104 RFGSQTR---NFRLYYDGKHFVGEKRFESIH------DL---VTDGLITLYI-ETKAAEYIAKMT 155

  Fly  1052 ILQRYKSVSIGNLLDLPG-----------EDDKKSI----KNRMRMKFAVNSNVFRINRS-PKSE 1100
            |...|:.:....|...|.           .|:|::.    .:..|:...|.....:.|.. ||.|
  Rat   156 INPIYEHIGYTTLNREPAYKQHMAVLKETHDEKEATGQDGVSEKRLTSLVRRATLKENEQIPKYE 220

  Fly  1101 K----KSRSRRGQVNSLYLDEQKYPLFAAPLSALELNMTDHPN----VPR--------------- 1142
            |    |..:.||.....|.....:.|.|..:...:..:..|..    ||.
  Rat   221 KVHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSC 285

  Fly  1143 --------------FVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTD-- 1191
                          .|||:|....:...:..:||||.||...|:::::.    .:|....|.|
  Rat   286 DLTTLVKAHITKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKM----AFDRDGEKADIS 346

  Fly  1192 -----DIHTLTSLHKQFFRELTSPLITQEAYERL---GRSLNDDAAIERMSLAFDDMPEPNRSTL 1248
                 ||:.:|...|.:||:|..||||.:||.:.   .:.::.|..:|.:..|...:|..:..||
  Rat   347 VNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIVDPDEQLETLHEALRSLPPAHCETL 411

  Fly  1249 RFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQIQ-----LDIGRMNMLAKVLIENYDRIF 1308
            |:|:.||.||......|.|.:.||.||:||.|:.:.::.     .||....::.::||:|.|.:|
  Rat   412 RYLMAHLKRVTLHEKENLMSAENLGIVFGPTLMRSPELDPMAALNDIRYQRLVVELLIKNEDILF 476

  Fly  1309  1308
              Rat   477  476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1285	CDD:459875	49/182 (27%)
Chn1	XP_006234448.1	SH2_a2chimerin_b2chimerin	59..145	CDD:198215	19/103 (18%)
		C1_alphaCHN	218..274	CDD:410406	12/55 (22%)
		RhoGAP_chimaerin	283..476	CDD:239837	54/196 (28%)