Protein Alignment RhoGAP18B and arhgap27

DIOPT Version :9

• Sequence 1: NP_573352.2
• Gene: RhoGAP18B / 32898
• FlyBaseID: FBgn0261461
• Length: 1317
• Species: Drosophila melanogaster
• Sequence 2: XP_002933206.3
• Gene: arhgap27 / 779583
• XenbaseID: XB-GENE-982958
• Length: 1024
• Species: Xenopus tropicalis
• Alignment Length: 1184
• Identity: 240/1184 - (20%)
• Similarity: 403/1184 - (34%)
• Gaps: 375/1184 - (31%)

  Fly   311 SSSAEESTVTLRRSTEESAK-CADE-------QAKLVKDFKRKLQQKRAHNVEPEREQRRCAITA 367
            |....|..:.|:|:.|...: |.|:       .||.||..  .|..||.:..:|.::.......|
 Frog    29 SIKPNERYILLKRTNEHWWQVCLDKTTTPFYIPAKYVKVL--PLASKRFNGYQPYKDPSEDVQVA 91

  Fly   368 NFVNDYLSALGEEKEAVQHQQVAAIEEHVAVVAIAIQPQVSVSLLRLMQSLALSASLHVSVRGFL 432
            ...|:|     ..|......||:|   :|....:.|||.::.:.:......|..|...|.|
 Frog    92 VPSNEY-----SYKFLPPCPQVSA---NVTPPPLDIQPAITDNAITSRNECASKALAPVKV---- 144

  Fly   433 TAYDKSFSLWLWHQQQQQRQQPPINGYRRRRARDSVVGVVGDWRRRLPLFAF-SFAGGNDRSVAS 496
                                 |.||                 ....||..:. ..|..|  ::.|
 Frog   145 ---------------------PCIN-----------------TSNTLPKVSMPKLAATN--TLPS 169

  Fly   497 ASV------SVSPAISESVDVCAAAASRRRANRS----TRRRGTAIVREEG-----------VCG 540
            |:|      :|.|.:...:.:.....|..:.:.|    |..:..:..:.|.           |||
 Frog   170 ATVPRVNSNNVQPKVVPQIHINDVLTSTPQIHSSNILPTNDKQNSATQPEPSTQFLPSDLPMVCG 234

  Fly   541 GESSTSSNNSKKNNNNNSNNNSGALMAAP--------KPNGEAERPS----TNSNNNTINCSSNN 593
            .....||:...|....:|..:      ||        |.....:|.|    |::..|.:...|:.
 Frog   235 ASGLDSSHTYPKEQPEDSRTH------APMRTFHNSKKVVDPTKRISFLCLTDAQPNILTTPSSG 293

  Fly   594 N---NDNISNNNNNHHTVDNESG---------INNNKNNDGNANCNVNEQQQQQQQQPITQNCVI 646
            |   ..:.:.:....|.:::.||         :.:|.......:..|...::::...|:.:|.
 Frog   294 NLKPEPSTTYHQQQPHKINDSSGLCCPEQVVIVTSNTAGSNGISPLVQPIKEEEDCGPLYENL-- 356

  Fly   647 KVRRPAPKVPVRNPNTSL--SNPRQIEEEQTKPNGGKKDNLRGNSFAAENS--SPEEQEEESIYQ 707
               :|..|...|...:||  |:...:::.:|..:.|.......||.....:  ||.:|.|:.
 Frog   357 ---KPFQKETPRERASSLQHSSTSTLDDWETHTDTGSGQLFYYNSVTGVTTWDSPFDQPEDP--- 415

  Fly   708 PIWQFKTIEPVDQEIIEALPVEGEDEEDEDEEDDDVDDEEEDLGDYDESLPSDA--DPDV--MAL 768
                    ||....:....|:.      ||.:.:...||......:..|:..:.  ||.|  |:.
 Frog   416 --------EPSPTSLNSLSPLA------EDSQWEKHFDEATKKYYFYNSVTGETSWDPPVEEMSF 466

  Fly   769 QAAAVFAAGVRHKLSTSTLTKRSKMMMPTPLPSPTASMDHGAWETDMEFMYSRESKEEA---DET 830
            |..                         ||:.|...|:|.            |....||   |.|
 Frog   467 QEF-------------------------TPMVSSYISVDR------------RPPTPEADYPDYT 494

  Fly   831 LSLGSTVTNSTATLGSISSTGSSVTGQPKDTP---KDLPADQQPSVVVHPILRNIC-------IF 885
            |..|.:..::               ...:|.|   :.:|..:.|   |.|.....|       .|
 Frog   495 LEEGESYPDA---------------DYHQDPPGLYEQIPLHKSP---VDPNSGWFCQVNKDGKKF 541

  Fly   886 YS---------QKDPKKYSAIFYDYHLSLVHQRFMTRIRRPAPPPPAQLATSNTTSLAPRSDDSG 941
            ||         |.:.:.....||....|| .|..:.||      .||.|...|        ||:.
 Frog   542 YSNNYNSEIWVQSEDQSGKTFFYTQDGSL-SQWSLPRI------GPASLHRPN--------DDNN 591

  Fly   942 CSCEAEDSY-----------------------------NHQHNPTPAIP--------------KP 963
            ...:.:|:|                             :|..:.|.::.              |.
 Frog   592 VFTKLQDNYPAITARKDTEDFGHRLRRAGSEDFLNVGGDHHPHQTKSLEKAGVLHKAKISDNGKK 656

  Fly   964 LKEEWERA--VLAAGAVA----GKR---------------------------GVAPRTGRK---- 991
            |::.|..:  ||..|.:.    ||.                           ....::.:|
 Frog   657 LRKSWSSSWTVLEGGILTFFRDGKNLSSNSSRHSQLSTPEYTVRLEGASLVWATKDKSSKKHVLE 721

  Fly   992 LRVRSNARLLL---TDSVLA-WRETLQDVNCCEDEEDMIVPVTDILRAQQIQEDNEVQQTQQSTI 1052
            |:.|:.:..|:   ::::.| |.|::::               .|.|..::..|:..:...:.
 Frog   722 LKTRNGSEYLIHHDSETITADWHESIKN---------------SIARNIRVSADHTPEDEPEP-- 769

  Fly  1053 LQRYKSVSIGNLLDLPGEDDKKSIKNRMRMKFAVNSNVFRINRSPKSEKKSRSRRGQVNSL---- 1113
            .|.:     |:...|..:|:||:    ..|....||:..|..|:  ..||...||..:.||
 Frog   770 FQEF-----GSTEKLGTKDEKKN----SSMGSGSNSDSDRKVRA--KLKKFLQRRPTIQSLRDRG 823

  Fly  1114 YLDEQKYPLFAAPLSALELNMTDHPNVPRFVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKK 1178
            |:.||   :|..||.  :|...:..|||.||......:|: ..::.|||||.|||...:.:||.|
 Frog   824 YIKEQ---VFGCPLQ--QLCEREKQNVPDFVRKAIQAVEK-RGLDIDGLYRVSGNLATIQKLRHK 882

  Fly  1179 L-----THVYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQEAYERLGRSLN-DDAAIERMSL-- 1235
            :     |::.|.||   :|:|.:|...|.|||||..||.....::....::. :|.|:::...
 Frog   883 VDQEENTNLEDGRW---EDVHVITGALKLFFRELPEPLFPFSHFDMFIETIKLNDPALKKKQFKE 944

  Fly  1236 AFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLL-----SANQIQLDIGRMNM 1295
            ....:|.||:.|::||.|||.:|.....||||...::|||:||.||     .|| |.:.:...|.
 Frog   945 LIQSLPPPNQETMQFLFRHLCKVIECKDSNRMSIQSVAIVFGPTLLRPSIEGAN-IAMYMVFQNQ 1008

  Fly  1296 LAKVLIENYDRIFH 1309
            :.:.::..|..||:
 Frog  1009 IVEQVLSQYKYIFN 1022

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	56/160 (35%)
arhgap27	XP_002933206.3	SH3_ARHGAP27	11..67	CDD:213002	10/37 (27%)
		PHA03247	<91..489	CDD:223021	88/514 (17%)
		WW	434..460	CDD:395320	4/25 (16%)
		PH_ARHGAP9-like	640..753	CDD:270053	16/127 (13%)
		RhoGAP_ARHGAP27_15_12_9	830..1016	CDD:239868	63/192 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000816
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000