DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP18B and Arhgap12

DIOPT Version :9

Sequence 1:	NP_573352.2	Gene:	RhoGAP18B / 32898	FlyBaseID:	FBgn0261461	Length:	1317	Species:	Drosophila melanogaster
Sequence 2:	XP_006526377.1	Gene:	Arhgap12 / 75415	MGIID:	1922665	Length:	843	Species:	Mus musculus

Alignment Length:	933	Identity:	191/933 - (20%)
Similarity:	315/933 - (33%)	Gaps:	357/933 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   524 STRRRGTAIVREEGVCGGESSTSSNNSKKNNNNNSNNNSGALMAAPKPNGEAERPSTNSNNNTIN 588
            |:..:||.::|:                .|.|..||.|||                     .|:|
Mouse   118 SSSVQGTGLIRD----------------ANQNFGSNYNSG---------------------QTLN 145

  Fly   589 CSSNNNNDNISNNNNNHHTVDNESGINNNKNNDGNANCNVNEQQQQQQQQPITQNCVIKVRRPAP 653
            .|.:..::|...|:::|                                              :|
Mouse   146 LSLDLTHNNGKFNSDSH----------------------------------------------SP 164

  Fly   654 KVPVRNPNTSL----SNPRQIEEEQTKPNGGKKDNLRGNSFAAENSSPEEQE-EESIYQPIWQFK 713
            ||..:| .|.|    ..|..::.|:|             ||:.|.|.....| .|.|.|
Mouse   165 KVSSQN-RTRLFGHFPGPEFLDIEKT-------------SFSQEQSCDSAGEGSERIQQ------ 209

  Fly   714 TIEPVDQEIIEALPVEGEDEEDEDEEDDDVDDEEEDLGDYDESLPSDADPDVMALQAAAVFAAGV 778
                              |.|..||......::..     ..:.|:...||      :.|:|...
Mouse   210 ------------------DSESGDELSSSSTEQMR-----ATTPPNQGRPD------SPVYANLQ 245

  Fly   779 RHKLSTSTLTKRSKMMMPTPLPSPTASMDHGAWETDME-----FMYSRESKEEADETLSLGSTVT 838
            ..|:|.|.|         .|||...|...:|.|||..:     :.|:|.::|.
Mouse   246 ELKISQSAL---------PPLPGSPAIQVNGEWETHKDSSGRCYYYNRTTQER------------ 289

  Fly   839 NSTATLGSISSTGSSVTGQPKDTPKDL--------PADQQPSVVVHPILRNICIFYSQKD----- 890
                            |.:|....:|:        |.:|:| :.......:.|  :||.|
Mouse   290 ----------------TWKPPRWARDVSTSRDFQSPGEQEP-LSSEENYHSSC--FSQSDSQCGS 335

  Fly   891 -PKKYS-----------------------------AIFYD------------YHLSLVHQRFMTR 913
             |:.:|                             ..:|.            |:.|...||.:.:
Mouse   336 PPRGWSEELDERGHTLYTSDYTKEKWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIK 400

  Fly   914 IR---RPAPPPPAQLATSNTTSLAPRSDDSG------CSCEAED---SYNHQHNPTPAIPKPLKE 966
            .|   |....|.......::|.:...:|...      |..|.|.   |..|| :|
Mouse   401 SRSLDRRLQEPIVLTKWRHSTIVLDSNDKDSPTTTKLCLPENESPPTSSKHQ-DP---------- 454

  Fly   967 EWERAVLAAGAVAG--KRGVAPRT-----GRKLR--------VRSNARLLLT---DSVLAWRETL 1013
                    ||::.|  |.|:...|     |:|:|        |...:.||.|   .|..:|..:.
Mouse   455 --------AGSLKGQEKYGLLNVTKITENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSN 511

  Fly  1014 QDVNCCEDEEDMIVPVTDI-------------LRAQQ-----IQEDNEVQQTQQSTILQRYKSVS 1060
            |...  |...|:...|.::             |:.:|     ||.||:........:|    |.:
Mouse   512 QSKP--EFTVDLKGAVIEMASKDKSSKKNVFELKTRQGTELLIQSDNDAVINDWFKVL----SST 570

  Fly  1061 IGNLL------------DLPG------EDDKKSIKNRMRMK-FAVNSNVFRINRSPKSEKKSRSR 1106
            |.|.:            |.||      |.|:|.:|....|| .:::|:  ...::.|:.||..:|
Mouse   571 INNQVAEADEAAEEETPDSPGVEKHDKEKDQKELKKLRSMKGSSMDSS--EQKKTKKNLKKFLTR 633

  Fly  1107 RGQVNSL----YLDEQKYPLFAAPLSALELNMTDHPNVPRFVVDVCAYIEQPECIEQDGLYRASG 1167
            |..:.::    |:.:|   :|.:.|:  .|...::..||:||.....::|: ..::.||:||.||
Mouse   634 RPTLQAVREKGYIKDQ---VFGSNLA--NLCQRENGTVPKFVKLCIEHVEE-HGLDVDGIYRVSG 692

  Fly  1168 NKVLVDELRKKLTH-----VYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQEAYERLGRSLNDD 1227
            |..::.:||..:.|     :.|.:|   :|||.:|...|.|||||..||.|...:.....::..:
Mouse   693 NLAVIQKLRFAVNHDEKLDLNDSKW---EDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQE 754

  Fly  1228 AAIERMSLAFD---DMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLL----SANQ 1285
            .. :|::...|   .:|:||:.|::.|.|||.||......|||...::|||:||.||    ....
Mouse   755 PR-QRVTAVKDLIRQLPKPNQDTMQILFRHLKRVIENGEKNRMTYQSIAIVFGPTLLKPERETGN 818

  Fly  1286 IQLDIGRMNMLAKVLIENYDRIF 1308
            |.:.....|.:.::::.....:|
Mouse   819 IAVHTVYQNQIVELILLELSTVF 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	52/159 (33%)
Arhgap12	XP_006526377.1	SH3_ARHGAP12	13..72	CDD:213003
		SH3-WW_linker	69..264	CDD:374675	51/286 (18%)
		PRP40	257..>409	CDD:227435	29/182 (16%)
		WW	266..296	CDD:238122	9/57 (16%)
		PH_ARHGAP9-like	462..573	CDD:270053	25/116 (22%)
		RhoGAP_ARHGAP27_15_12_9	651..836	CDD:239868	57/191 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000816
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100