DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP18B and arhgap32

DIOPT Version :9

Sequence 1:	NP_573352.2	Gene:	RhoGAP18B / 32898	FlyBaseID:	FBgn0261461	Length:	1317	Species:	Drosophila melanogaster
Sequence 2:	XP_004916221.2	Gene:	arhgap32 / 734056	XenbaseID:	XB-GENE-1002474	Length:	1995	Species:	Xenopus tropicalis

Alignment Length:	253	Identity:	68/253 - (26%)
Similarity:	118/253 - (46%)	Gaps:	39/253 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1078 NRMRMKFAVNSNVFRINRSPKSEKKSRSRRGQVNSLYLDEQKYPLFAAPLSALELNMTDHPNVPR 1142
            :|...|.......|..:|..|.:.|.|.        .|.|:   :|...|....||  ...:||:
Frog   382 SRKHGKLITFLRTFMKSRPSKQKLKQRG--------ILRER---VFGCDLGEHLLN--SGQDVPQ 433

  Fly  1143 FVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLK-------TDDIHTLTSLH 1200
            .:.....:||:...:  ||:||.||    :....:||.|.:|...:.       ..|||.:.||.
Frog   434 VLRSCTEFIEKHGIV--DGIYRLSG----IASNIQKLRHEFDSEQIPDLTKDVYIQDIHCVGSLC 492

  Fly  1201 KQFFRELTSPLITQEAYERLGRSLN---DDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAAS 1262
            |.:||||.:||:|.:.||:...:::   |:..:.::......:|.|:..||.||:|||:|:|...
Frog   493 KLYFRELPNPLLTYQLYEKFSDAVSAATDEERLVKIHDVIQQLPPPHYRTLEFLMRHLSRLATYC 557

  Fly  1263 ASNRMPSTNLAIVWGPCLLSANQIQ----------LDIGRMNMLAKVLIENYDRIFHP 1310
            :...|.:.||||||.|.||.:.||:          :::...:::.:.::.:.:.:|.|
Frog   558 SITNMHTKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVEVLFSP 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	52/167 (31%)
arhgap32	XP_004916221.2	PX_RICS	131..245	CDD:132831
		SH3_ARHGAP32_33	267..320	CDD:212769
		RhoGAP_CdGAP	414..608	CDD:239849	57/204 (28%)
		ZipA	<1758..>1898	CDD:225657
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910