DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP18B and chn2

DIOPT Version :9

Sequence 1:	NP_573352.2	Gene:	RhoGAP18B / 32898	FlyBaseID:	FBgn0261461	Length:	1317	Species:	Drosophila melanogaster
Sequence 2:	XP_699642.6	Gene:	chn2 / 570999	ZFINID:	ZDB-GENE-091020-5	Length:	466	Species:	Danio rerio

Alignment Length:	203	Identity:	57/203 - (28%)
Similarity:	97/203 - (47%)	Gaps:	24/203 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1122 LFAAPLSALELNMTDHPNVPR-FVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLTHVYDP 1185
            :|:..|:.|   :..| |.|| .|:|:|....:...::.:||||.||....::::|..    :|.
Zfish   272 VFSCDLTTL---VKAH-NTPRPMVLDMCIREIEHRGLKSEGLYRVSGFTEHIEDVRLS----FDR 328

  Fly  1186 RWLKTD-------DIHTLTSLHKQFFRELTSPLITQEAYERL---GRSLNDDAAIERMSLAFDDM 1240
            ...|.|       ||:.:....|.:.|:|..|:||.:.|.|.   .:..:.|:.:|.:......:
Zfish   329 DGEKADISANIYPDINIIAGALKLYLRDLPIPVITYDVYSRFIQAAKITDPDSRLEAVHDGLLQL 393

  Fly  1241 PEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQIQL-----DIGRMNMLAKVL 1300
            |..:..|||:|:.||.||......|.|.|.||.||:||.|:....:..     |:....::.::|
Zfish   394 PPAHYETLRYLMTHLKRVTMYEKDNYMNSENLGIVFGPTLMRPPDLNTLTTLNDMRYQKLIVQLL 458

  Fly  1301 IENYDRIF 1308
            ||:.|.:|
Zfish   459 IEHEDILF 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	46/163 (28%)
chn2	XP_699642.6	SH2_a2chimerin_b2chimerin	52..138	CDD:198215
		C1_1	213..265	CDD:278556
		RhoGAP_chimaerin	273..466	CDD:239837	56/200 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910