DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP18B and arhgap32b

DIOPT Version :9

Sequence 1:	NP_573352.2	Gene:	RhoGAP18B / 32898	FlyBaseID:	FBgn0261461	Length:	1317	Species:	Drosophila melanogaster
Sequence 2:	XP_009293685.1	Gene:	arhgap32b / 569434	ZFINID:	ZDB-GENE-091204-147	Length:	1956	Species:	Danio rerio

Alignment Length:	246	Identity:	69/246 - (28%)
Similarity:	118/246 - (47%)	Gaps:	39/246 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1091 FRINRSPKSEKKSRSRRGQVNSLYLDEQKYPLFAAPLSALELNMTDHPNVPRFVVDVCAYIEQPE 1155
            |..:|..|.:.|.|.        .|.|:   :|...|....|| :.| :||:.:.....:||:..
Zfish   388 FMKSRPTKQKLKQRG--------ILRER---VFGCDLGEHLLN-SGH-DVPQVLKSCTEFIEKHG 439

  Fly  1156 CIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLK-------TDDIHTLTSLHKQFFRELTSPLIT 1213
            .:  ||:||.||    :....:||.|.:|...:.       ..|||.:.||.|.:||||.:||:|
Zfish   440 VV--DGMYRLSG----IASNIQKLRHEFDSEQIPDLTKDVYIQDIHCVGSLCKLYFRELPNPLLT 498

  Fly  1214 QEAYERLGRSLN---DDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIV 1275
            .:.||:...:::   |:..:.::......:|.|:..||.||:|||:.:|..|....|.:.|||||
Zfish   499 YQLYEKFSEAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSHLATFSYVTNMHTKNLAIV 563

  Fly  1276 WGPCLLSANQIQ----------LDIGRMNMLAKVLIENYDRIFHPDNERLV 1316
            |.|.||.:.||:          :::...:::.:.::.:.|.:|.|....|:
Zfish   564 WAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSPKLSSLI 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	52/167 (31%)
arhgap32b	XP_009293685.1	PX_domain	124..238	CDD:295365
		SH3_ARHGAP32_33	260..313	CDD:212769
		RhoGAP_CdGAP	407..601	CDD:239849	58/204 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810