Protein Alignment RhoGAP18B and RhoGAP19D

DIOPT Version :10

• Sequence 1: NP_573352.2
• Gene: RhoGAP18B / 32898
• FlyBaseID: FBgn0261461
• Length: 1317
• Species: Drosophila melanogaster
• Sequence 2: XP_061502159.1
• Gene: RhoGAP19D / 5666818
• VectorBaseID: AGAMI1_014188
• Length: 2337
• Species: Anopheles gambiae
• Alignment Length: 1526
• Identity: 309/1526 - (20%)
• Similarity: 479/1526 - (31%)
• Gaps: 571/1526 - (37%)

  Fly    84 PPPPPLST-ISGESSNIYENICDLCRGIYSDNERCRCQRSETPAKAPAPSTPTTP---------- 137
            ||..|||. .||...:                            ||||||||:|.
Mosquito   410 PPTQPLSPGFSGAGGD----------------------------KAPAPSTPSTSTHASPTAAGV 446

  Fly   138 ----PTPPTKVKSRSLL-GYSKSSAATLTRL---------FGSLKQLNRSSSLQRRIFP---RTP 185
                |.|||.....|.. |..:..|:.|:.:         .|||:...:|:.....|.|   ..|
Mosquito   447 SPPGPKPPTNAGGASTTNGVMREHASQLSAIREHFFTGGVGGSLQLPPKSAPPSLAIAPAAITVP 511

  Fly   186 TTGSSSAGSLEI------IHNVDE---VFRTQETFDLQRICELKLEQQQLKGSQSDQHIYGRVRE 241
            ...||..|:..:      :|.|.|   :|.:......:.|..:.|.:.:|....:.|.:
Mosquito   512 AGPSSPTGAATVPLSPHSLHAVSEKAKLFESGRPLSPEGIDRMDLYKSELSRINTKQVV------ 570

  Fly   242 PEESQSHKRERKRPRVSRIRL---LQDESTSGSSSLYLNESICQWMTSLRRQVHHYDEGPWQQPK 303
                         |.|:..|.   |:.|||.             |..|:       |:    :|:
Mosquito   571 -------------PNVAVRRKEFELKAESTG-------------WRKSI-------DD----KPR 598

  Fly   304 SVPARDPSSSAEESTVTLRRSTEESAKCADEQAKLVKDFKRKLQQKRAHNVEPEREQRRCAITAN 368
            ||.:   .|.:..:.|.||..:.||....|.:..|...                        |..
Mosquito   599 SVSS---DSESRRTPVRLRSLSVESNATRDSRHSLASS------------------------TLQ 636

  Fly   369 FVNDYLSALGEEKEAVQHQQVAAIEEHVAVVAIAIQPQVSVSLLRLMQSLALSASLHVSVRGFLT 433
            ..:.....|.::||. |||.
Mosquito   637 ATDAAFDTLEKDKEN-QHQP--------------------------------------------- 655

  Fly   434 AYDKSFSLWLWHQQQQQRQQ-----PPINGYRRRRARD-----SVVGVVGDWRRRLPLFAFSFA- 487
                        |||||:||     ||:...|::..||     :|......|.:. |:.|.:.|
Mosquito   656 ------------QQQQQQQQPSAVPPPMPMLRQKPIRDDSYRSAVRNSTAFWLQG-PVPAAAAAA 707

  Fly   488 ------GGNDRSVASASVSVS----PAISESVDVCAAAASRRR-----ANRSTRRRGTAIVREEG 537
                  ||.....:|::||::    |.......|...||:.|:     |..:.:.|...:.|.:.
Mosquito   708 HGGGVGGGPGTGDSSSAVSLASDGEPPSRPVPPVRTYAAAHRQQHPLSAADTEQMRKKQLHRNQT 772

  Fly   538 VCG------GE--------------------------------SSTSSNNSKKNNNNNS--NNNS 562
            :.|      ||                                ||.:|.:|....:..:  .:.:
Mosquito   773 MVGLHHLLDGEDGDGPLGDVEMLHRMPPLTSPPFAPLSPLAVASSVTSTSSVPLAHLGALGEHPA 837

  Fly   563 GALMAAP----------KPNGEAERPSTNSNNNTIN-CSSNNNNDNISNNNNNHHTV---DNESG 613
            ||....|          :|.....||:      |:| |........:......||::   |.:..
Mosquito   838 GAAGTTPQQLPPPPGGFRPVAGPMRPT------TLNLCPDAALPTVVMRQKQPHHSLLLDDEDRK 896

  Fly   614 INNNKNNDGNANCNVNEQQQQQQQQPITQNCVIKVRRPAPKVPVRNPNTSLSNPRQIEEEQTKPN 678
            :.........|:.|:   .|..:..|.:.        |....|...|:|..:.|.....|
Mosquito   897 MRRVSYLRATAHDNL---FQMLESDPDSS--------PMSLPPADTPDTDPTEPASSTVE----- 945

  Fly   679 GGKKDNLRGNSFAAENSSP-----EEQEEESIYQPIWQ----FKTIEPV----DQE---IIEALP 727
                  |.......:..:|     :.|:.:|.|:| |:    ...|:|:    |.|   .:.|||
Mosquito   946 ------LSSGLATTDEGAPASGKLQPQQLKSAYRP-WRRPRLTTDIQPLRRLFDPEADLAVPALP 1003

  Fly   728 VEGEDE-----------------------EDEDEEDDDVDDEEEDLGDYDESLPSDADPDVMALQ 769
            ...|.|                       :|:|.:|||.||.:||.|.
Mosquito  1004 PILETEPFTSASASKKRSRPLPTPPRLPNDDDDADDDDADDADEDEGG----------------- 1051

  Fly   770 AAAVFAAGVRHKLSTSTLTKRS-KMMMPTPLPSPTASMDH---GAWETDMEFMYSRESKEEADET 830
                 |||.|.......:..|| .::..||..|.|.. .|   ||                   .
Mosquito  1052 -----AAGTRPARPARAVKGRSASLVTTTPFGSATGG-GHRLFGA-------------------A 1091

  Fly   831 LSLGSTVTNSTATLGSISSTGSSVTGQPKDTPKDLPA---DQQPSVVVHPILR--NICIFYSQKD 890
            .|||:....:|.|.|.| .|.:....|...|.....|   |...:....|::|  .:.:..:..|
Mosquito  1092 GSLGNLHVITTTTAGGI-VTRNYFFAQSHGTKSKALAHFRDGGAADSTEPVVREGELHVKVTLID 1155

  Fly   891 PKKYS--------AIFYDYHLSLVHQRFMTRIRR-------PAPPPPAQLATSNTTSLAPRSDDS 940
            .|:.:        |:...:||.|      |.:|.       |.|.....|...:.|
Mosquito  1156 GKRSADRSWRTVHAVLRGHHLKL------TLVREGKNSNQSPEPCGTIDLTNFHVT--------- 1205

  Fly   941 GCSCEAEDSYNHQHNP---TPAIPK--PLK----------EEWERAVLAAG-AVAGKRGVAPRT- 988
                  |.:|..:.|.   |.|...  ||:          .|..|...|:| |..|..|....|
Mosquito  1206 ------EGNYTKRKNVFKLTTAAGSYCPLEAAAAAGFGGHAEVHRTQSASGLATVGGSGPGSSTC 1264

  Fly   989 GRKLRVRSNA--------RLLLTDS---VLAWRETLQDVNCCEDEEDMIVPVTDILRAQQIQEDN 1042
            ...:|..|.|        .||..||   :..|.|:|:.|  |.....:..|  |.|..:..|:..
Mosquito  1265 ASSVRSASTAGLPGSERELLLQADSHGDMEGWMESLRLV--CGSTGQLHSP--DYLSGRGGQQAE 1325

  Fly  1043 EVQQTQQSTILQRYKSVSIGNLLDLPGEDDKKSIKNRMRMKFAVNSNVFRINRSP-------KSE 1100
            ..:...|:::..:..||...|    .|:|....:..:.:.|:|:.|      |||       ||.
Mosquito  1326 PQRIAAQTSVQVQGGSVGGSN----SGDDYSPVLPAKSQRKYALGS------RSPSGQSPVTKSR 1380

  Fly  1101 K------------------------------------------------------------KSRS 1105
            |                                                            ||::
Mosquito  1381 KTPQAGCSSPTDSADQSIASTSNQPAYHQPPHHYQQQQQQQHHHHHHHGAKDSSDRESGSPKSKT 1445

  Fly  1106 RRGQVNSLYLDEQKYPLFA-----APLSALELNMTDHPNVPRF---VVDVCAYIEQPECIEQDGL 1162
            .:|.:.:.:...|..|..|     || :.|.|.:....:..||   ||:.|..:.:.:.:...|:
Mosquito  1446 WKGIMAAKFRKMQWQPAAADLPDNAP-TGLPLELCPVSSRNRFLPLVVEKCISVVESKGLLVVGI 1509

  Fly  1163 YRASGNKVLVDELRKKLTH------VYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQEAYERLG 1221
            ||..||...:..|.:.:..      :.||||   ||::.::||.|.|||.|..|::....|.  |
Mosquito  1510 YRIPGNTAAIAALTETINRGLDEVALNDPRW---DDVNVVSSLLKAFFRNLPQPVLPDAMYR--G 1569

  Fly  1222 RSLNDDAAIERMSLAFDDM----PEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLL- 1281
            ....|..:.:|..:|...|    |..|..||::|:|||..|.|.|.:|.|...|||||:||.::
Mosquito  1570 FISADQQSGQRRLIALRQMLERIPRMNYETLKYLMRHLVLVTAHSEANLMDPRNLAIVFGPSVVR 1634

  Fly  1282 -SANQIQ---LDIGRMNMLAKVLIENYDRIF 1308
             :::.||   :|:.....:.:|||..|...|
Mosquito  1635 CTSDSIQSAVMDMRHQCQIIEVLIIYYAYFF 1665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1285	CDD:459875	51/158 (32%)
RhoGAP19D	XP_061502159.1	None