Protein Alignment RhoGAP18B and arhgap29a

DIOPT Version :10

• Sequence 1: NP_573352.2
• Gene: RhoGAP18B / 32898
• FlyBaseID: FBgn0261461
• Length: 1317
• Species: Drosophila melanogaster
• Sequence 2: XP_693227.4
• Gene: arhgap29a / 564805
• ZFINID: ZDB-GENE-030131-9510
• Length: 1344
• Species: Danio rerio
• Alignment Length: 774
• Identity: 137/774 - (17%)
• Similarity: 252/774 - (32%)
• Gaps: 260/774 - (33%)

  Fly   628 VNEQQQQQQQQPITQNCVIKVRRPAPKVPVRNPNTSLSNPRQIEEEQTKPNGGKKDNLRGNSFAA 692
            |.||.|::|::....:..::..|............:.|:..::||||....|||:...|
Zfish   344 VKEQWQREQKKMHEADSALRKARLLQAQRQEEYEKARSSTSRVEEEQISGAGGKQLEKR------ 402

  Fly   693 ENSSPEEQEEESIYQPIWQFKTIEPVDQEIIEALPVEGEDEEDEDEED---DDVDDEEEDLGDYD 754
                 .:.|||::.:.                        ||.:|...   .||..:..||.
Zfish   403 -----RKLEEEALLKA------------------------EEAQDHYKLCVTDVGVKRVDLA--- 435

  Fly   755 ESLPSDADPDVMALQAAAVFAAGVRHKLSTSTLTKRSKMMMPTPLPSPTASMDHGAWETDMEFMY 819
                                      |..:..||:..:::....|.....:::   |       :
Zfish   436 --------------------------KTKSEILTQIRELVFQCDLTLKAVTVN---W-------F 464

  Fly   820 SRESKEEADETLSLGSTVTNSTATLGSISSTGSSVTGQPKDTPKDLPADQQPSVVVHPILRNICI 884
            ..:..:.|...::..|...||     .:...|...|    :..|.||:|:
Zfish   465 QMQQAQVASLPINFQSLCENS-----KLYEPGLCYT----EFVKSLPSDR--------------- 505

  Fly   885 FYSQKDPKKYSAIFYDYHLSLVHQRFMTRIRRPAPPPPAQLATSNTTSLAPRSDDSGCSCEAEDS 949
              |:.:.       :.:.:|..|.   |.::|.....||        :|...|..||....|::.
Zfish   506 --SRVES-------FSFDISSTHN---TGLKRAVNSTPA--------ALVHLSQVSGDFLSADEV 550

  Fly   950 YNHQHNPTPAIPKPLKEEWERAVLAAGAVAGKRGVAPRTGRKLRVRSNARLLLTDSVLAWRETLQ 1014
            .:|....|..:|                  ..|..:....:.||::...|:        ||.:.|
Zfish   551 ESHVQARTAKMP------------------DGRSHSTTDVQALRIQGPFRV--------WRTSSQ 589

  Fly  1015 DVNCCEDEEDM------------------------IVPVTDILRAQQIQEDNEVQQTQQSTILQR 1055
            ....|.|.|..                        ..|.|..:.:....::.|......:.:
Zfish   590 GGGMCSDSESAGGSSESRSMDSPTASPGDFKRRLPRTPSTGTMSSADDLDEREPPSPSDNGL--- 651

  Fly  1056 YKSVSIGNLLDLPGEDDKKSIKNRMRMKFAVNSNVFRINRSPKSEKKSRS--------------- 1105
              |..:......||     ..:| .:|..|..::..|..|:|...::..|
Zfish   652 --SEMVTEAASSPG-----PFRN-TQMSKAAQTHKLRKLRAPSKCRECDSLVVFHGAECEECSLA 708

  Fly  1106 -RRGQVNSLYLD------EQKYPLFAAPLSALELNMTDHPNVPRFVVDVCAYIEQPECIEQDGLY 1163
             .:..:.:|.:.      :.|..|||...:....|..|  .:| |::..|....:...:...|:|
Zfish   709 CHKKCLETLAIQCGHKKLQGKLHLFAIDFAQAAKNSPD--GIP-FIIKKCTSEIENRALNIKGIY 770

  Fly  1164 RASGNKVLVDELRKKLTHVYDPRWLKTDDI--HTLTSLHKQFFRELTSPLITQEAYERLGRSLND 1226
            |.:|.|..|::|.:...:..|  .::..|:  |.::::.|.:.|:|..|||       |.|..||
Zfish   771 RVNGAKSRVEKLCQAFENGKD--LVELSDLYPHDISNVLKLYLRQLPEPLI-------LFRYYND 826

  Fly  1227 --DAAIERMSLAFDD--------------------------------MPEPNRSTLRFLIRHLTR 1257
              ..|.|..|:..|:                                :|..:..||:|||:||.|
Zfish   827 FIGLAKESQSIIVDEVEASRGCPTSDTPQISVELNRVLFKIKDLLRQLPPAHYKTLQFLIQHLHR 891

  Fly  1258 VAAASASNRMPSTNLAIVWGPCLLSANQIQLDIGRMN--------MLAKVLIENYDRIF 1308
            |:..:..|:|.|:||.|::||.|:...|...::...:        ::.::||.:|:.||
Zfish   892 VSERADENKMTSSNLGIIFGPTLIKPRQADAEVSLSSLVDYPYQALIVELLIRHYEMIF 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1285	CDD:459875	46/179 (26%)
arhgap29a	XP_693227.4	BAR	230..484	CDD:472257	32/213 (15%)
		C1_GMIP-like	675..725	CDD:410366	5/49 (10%)
		RhoGAP	733..945	CDD:470621	53/223 (24%)