DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP18B and arhgap27

DIOPT Version :9

Sequence 1:	NP_573352.2	Gene:	RhoGAP18B / 32898	FlyBaseID:	FBgn0261461	Length:	1317	Species:	Drosophila melanogaster
Sequence 2:	XP_005156083.1	Gene:	arhgap27 / 564211	ZFINID:	ZDB-GENE-030131-3922	Length:	999	Species:	Danio rerio

Alignment Length:	1025	Identity:	197/1025 - (19%)
Similarity:	339/1025 - (33%)	Gaps:	332/1025 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   493 SVASASVSVSPAISESVDVCAAAASRRRANRSTRRRGTAIVREE-----GVCGGESSTSSNNSKK 552
            |:...|.:..||   .|.:....:.:|...:...|..|.|:.:|     |:......|.:.....
Zfish    98 SLQFGSQTADPA---EVTLRVPDSIKRDTEKDGHRISTFIIPKEFFELKGLDPDPIKTEAEAGPP 159

  Fly   553 NNNNNSNNNSG--ALMAAPKPNGEAERPSTNSNNNTINCSSNNNNDNISNNNNNHHTVD------ 609
            .::|.|:..:|  |.:..|.|   ....:|..:..|...|.::..|::.....:..|:|
Zfish   160 VSSNTSSPTNGETAFIILPPP---VYTVNTTQSTETDTRSVDDPKDSVGRPRVDSSTIDEDIQML 221

  Fly   610 NESG------INNNKNNDGNANCNVNEQQQQQQQQPITQNCVIKVRRPAPKVP---------VRN 659
            |.:|      :...:.|...:...|.|.:..:.:..:|.| ...|...||.|.         .|.
Zfish   222 NRAGWSEVLDVMGKEKNVYESLDTVREPESPKDEADMTVN-TTPVTPDAPMVEDDTAVYVNIPRK 285

  Fly   660 PNTSLSNPRQIE---EEQTKPNGGKKDNLRGNSFAAENSSPEEQEEESIYQP-----IWQ----F 712
            ..|:::|...|.   ::..:|    .:|...:|...:..:.::..:|..|||     .|:    .
Zfish   286 RQTTINNSSPIASLLQDFPEP----PENFLLDSAGWQVHTDDQSGQEFYYQPSTGRSTWENPLSS 346

  Fly   713 KTIE-PVDQEIIEALP--------------------------------------VEGEDEEDEDE 738
            :::| ||..|...:.|                                      |.|:...|..|
Zfish   347 RSMESPVGTEGGRSPPSFPQSPACSPVAPAPRRWSSDWEKVLDESTGRHYFFNTVSGQSSWDPPE 411

  Fly   739 EDDDVDDEEE--DLGDYDESLPSDADPDVMALQAAAVFAAGVRHKLSTSTLTKRSKMMMPTPLPS 801
               |||....  .|.|....||.:..|....|:.|:                       |..:|:
Zfish   412 ---DVDSPGRLMFLDDCPPPLPEEDYPASPELEEAS-----------------------PVSIPA 450

  Fly   802 ------------PTASMDHGA---WETDME--------------------------FMYSRE-SK 824
                        |..|:|..:   |..|::                          :.|.|: ||
Zfish   451 EYSLIHVKKVSIPRVSLDRSSPAGWSLDIDSEGTWTFTSEYTQEQWIKSLDDQGRTYYYLRDGSK 515

  Fly   825 EE-------------ADETLSL------------------------GSTVTNSTATLGS------ 846
            .:             |.:.|:|                        |:..:....|:||
Zfish   516 SQWNLPEINPGQGGVAAQWLALLPYSKNVAGSSPGWYSASPGQYGVGNGASGEQDTVGSNWRHSA 580

  Fly   847 -----------ISSTGSSVTGQPKDTPKDLPADQQPSVVVHPILRNICIFYSQKDPKKYSAIFYD 900
                       |.:|..|......|||.::...::..     ||....:..:.|..:|.    :.
Zfish   581 GYPDDKNHSSYIQNTSDSEASSSPDTPHNVSNLEKAG-----ILNKTKVSENGKKVRKN----WG 636

  Fly   901 YHLSLVHQRFMTRIRRPAPPPPAQLATSNTTSLAPRSDDSGCSCEAEDSYNHQHNPTPAIPKPLK 965
            :..:::|...:|..:.|...|..  |:|.|..:.|
Zfish   637 HSWTVLHGGKLTFHKDPKSTPAG--ASSKTNQILP------------------------------ 669

  Fly   966 EEWERAVLAAGAVAGKRGVAP--RTGRK----LRVRSNARLLL---TDSVLA-WR----ETLQDV 1016
               |..|...||...:   ||  ::.:|    |:.|:.|..|:   |||::. |.    :|:..:
Zfish   670 ---EFTVDLKGATINR---APKDKSSKKNVLELKTRTGAEYLIQYDTDSIIQDWHKVILDTIHQL 728

  Fly  1017 NCCE---DEEDMIV---PVTDILRAQQIQEDNEVQQTQQSTILQRYKSVSIGNLLDLPGEDDKKS 1075
            |..:   :|||.::   |..|       :|:...::...||..::..:.|       ..|.::|.
Zfish   729 NGDQHHSEEEDEVIDKSPTLD-------REERPFEKRTMSTATRQPSTSS-------TSEAEQKK 779

  Fly  1076 IKNRMRMKFAVNSNVFRINRSPKSEKKSRSRRGQVNSLYLDEQKYPLFAAPLSALELNMTDHPNV 1140
            ::.:::.        |.:.|......|.:.        |:.|.   :|...|.  .|...:...|
Zfish   780 VRTKLKK--------FLLKRPTLQSVKDKG--------YIREN---VFGCHLH--NLCSQEKTRV 823

  Fly  1141 PRFVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLTH----VYDPRWLKTDDIHTLTSLHK 1201
            |.| |:.|....:...:|.|||||.|||..::.:||.|..|    :.:..|    |||.:|...|
Zfish   824 PSF-VEKCIRAVEKRGLEIDGLYRVSGNLAVIQKLRFKADHEDLDLEEGNW----DIHVITGALK 883

  Fly  1202 QFFRELTSPLITQEAYERLGRSLNDD---AAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASA 1263
            .|||||..||.....:.....::...   :.|..|......:|.||..|:..|..||.||.....
Zfish   884 LFFRELQEPLFPYNLFNEFICAIKTPDYYSKISHMRNLVRSLPPPNHDTMEALFSHLRRVIQHGN 948

  Fly  1264 SNRMPSTNLAIVWGPCLLSANQIQLDIGR----MNMLAKVLIENYDRIFH 1309
            .|||...|:|||:||.||...:....|..    .|.:.:.|:..::.|||
Zfish   949 ENRMTVQNVAIVFGPTLLKPEEETASIATYMVFQNQIVEFLLSEFESIFH 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	52/154 (34%)
arhgap27	XP_005156083.1	SH3	22..77	CDD:302595
		WW	315..343	CDD:278809	5/27 (19%)
		WW	382..410	CDD:278809	3/27 (11%)
		PH	613..726	CDD:278594	28/159 (18%)
		PH_ARHGAP9-like	614..725	CDD:270053	27/157 (17%)
		RhoGAP_ARHGAP27_15_12_9	808..992	CDD:239868	59/190 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000816
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100