DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP18B and arhgap12a

DIOPT Version :9

Sequence 1:	NP_573352.2	Gene:	RhoGAP18B / 32898	FlyBaseID:	FBgn0261461	Length:	1317	Species:	Drosophila melanogaster
Sequence 2:	XP_021336423.1	Gene:	arhgap12a / 563267	ZFINID:	ZDB-GENE-050809-38	Length:	853	Species:	Danio rerio

Alignment Length:	879	Identity:	185/879 - (21%)
Similarity:	308/879 - (35%)	Gaps:	307/879 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   645 VIKVRR---PAPKV--------PVRNPNTSLSNPRQIEEEQTKPNGGKKDNLRGNSFAAENSSPE 698
            |.:|||   |.||.        |..|..::|        |..:||..||......|..|  ..|.
Zfish    65 VREVRRALMPPPKPLNIAGRGGPAPNRPSAL--------EIQRPNDNKKSPCPSPSSTA--LLPP 119

  Fly   699 EQEEESIYQPIWQFKTIEPVDQEIIE-ALP----------VEGEDEEDEDEEDDD------VDDE 746
            ..:..|   |:...:.:.|....... :||          ::||.::|:|.|..|      |.:|
Zfish   120 RDDRGS---PVSPTRHLPPAQMNTFPGSLPCFRAESPGSKLDGERDKDKDSERKDRGEKAAVQEE 181

  Fly   747 -EEDLGDYD---------ESLPSDADPDVMALQA------AAVFAAGVRHKLSTSTLTKRSKMMM 795
             .|:.||.|         :.|.|.:..::.:|.:      :.|:......|:|.|:
Zfish   182 LAEEGGDSDKNRIDSESGDELSSGSTDNLQSLGSGQGRPDSPVYTNLQEMKISQSS--------- 237

  Fly   796 PTPLPSPTASMDHGAWETDME-----FMYSRESKE------EADETLSLGSTVTNSTAT--LGS- 846
            ..||||.:....:|.|||..:     :.|:|.::|      .|.::|.......:.|.|  |.|
Zfish   238 TPPLPSSSPIHTNGDWETHKDQNGRHYYYNRSTQERTWKPPRARDSLPRKEEKHDMTDTEVLSSE 302

  Fly   847 ---ISSTGSSVTGQPKDTPKDLPADQQPSVVVHPILRNICIFYSQK---DPKKYSAIFY------ 899
               :||...|..|.|       |......:..|.....:|.:.::|   ...:...::|
Zfish   303 ENCLSSQSDSQYGSP-------PRGWSEEMDEHGHTLYVCDYTNEKWLRHTDERGRLYYYSADGS 360

  Fly   900 --------------DYHLSL----VHQRFMTRIRRPAPPP------------------------- 921
                          ..|..|    :|:......|.|.|.|
Zfish   361 RSEWELPKIGLKSQSNHTPLMPGDLHKTRSLDRRLPDPIPISRTQRHSIYSHETNDKLKQKFVKV 425

  Fly   922 -----PAQLATSNTTSLAPR-----SDDSGCSCEAEDSYNHQHNPTPAIP-----------KPLK 965
                 |.:..|..:....|:     |.||..||.:  |....|:|:....           |.::
Zfish   426 RQSFLPRRKTTLRSHPYFPQDTKTGSPDSDSSCPS--SPKPPHSPSEKCATLNMTKITEHGKKVR 488

  Fly   966 EEW---------------------------------ERAV-LAAGAV--AGKRGVAPRTGRKLRV 994
            :.|                                 |.:| |..|:|  |.|...:.:...:|:.
Zfish   489 KNWTSYWTVLQGSLLIFNKGQGGGSGWFGRDQKSSVEYSVDLKGGSVDWASKDKSSKKHVLELKT 553

  Fly   995 RSNARLLL-TDS---VLAWRETLQDVNCCEDEEDMIVPVTDILRAQQIQEDNEVQQTQQSTILQR 1055
            |....||| :||   |..|.:.|                |:.:.....:.|..:::
Zfish   554 RQGTELLLQSDSDGLVNDWHKAL----------------TEAIHTYMWESDEAIEE--------- 593

  Fly  1056 YKSVSIGNLLDLP---------GEDDKKSIKNRMRMKFAVNSNVFRINRSPKSEKKSRSR----- 1106
                      |:|         .|.|:|:.|....:|...:.:        .:|:|.:::
Zfish   594 ----------DMPESPENEKHDKEKDRKNSKKARDIKKTASMD--------NAEQKKKNKLVVLL 640

  Fly  1107 --RGQVNSL----YLDEQKYPLFAAPLSALELNMTDHPNVPRFVVDVCAYIEQPECIEQ------ 1159
              |..:.::    |:.:|   :|...||:  |...::..|||||     ::    ||||
Zfish   641 LGRPTLQAVKDKGYIKDQ---VFGCSLSS--LCQRENSTVPRFV-----WL----CIEQVEKNGL 691

  Fly  1160 --DGLYRASGNKVLVDELRKKLTH-----VYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQEAY 1217
              |||||.|||..::.:||..:.|     :.|.:|   :|||..|...|.|||||..||.|...:
Zfish   692 GVDGLYRVSGNLAIIQKLRFAVNHEEKIDLGDSKW---EDIHVTTGALKMFFRELPEPLFTYTFF 753

  Fly  1218 ERLGRSLNDDAAIERMSLAFD---DMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPC 1279
            .....::......:::....|   .:|.||..|::.|.:||.:|......|||.:.::|||:||.
Zfish   754 SDFISAIKMPDYKQKVQTVKDLMKKLPRPNHDTIQVLFKHLKKVIQHVDENRMTTQSVAIVFGPT 818

  Fly  1280 LL-----SANQIQLDIGRMNMLAKVLIENYDRIF 1308
            ||     :|| :.:.:...|.:.::::..||.||
Zfish   819 LLRPEIETAN-MAVHMVYQNQIVELILMEYDTIF 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	55/168 (33%)
arhgap12a	XP_021336423.1	SH3_ARHGAP12	11..70	CDD:213003	2/4 (50%)
		SH3-WW_linker	67..233	CDD:318759	38/178 (21%)
		WW	252..278	CDD:306827	6/25 (24%)
		PH_ARHGAP9-like	470..580	CDD:270053	20/125 (16%)
		RhoGAP_ARHGAP27_15_12_9	660..846	CDD:239868	61/200 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000816
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010