Protein Alignment RhoGAP18B and arhgap12a

DIOPT Version :10

• Sequence 1: NP_573352.2
• Gene: RhoGAP18B / 32898
• FlyBaseID: FBgn0261461
• Length: 1317
• Species: Drosophila melanogaster
• Sequence 2: XP_021336423.1
• Gene: arhgap12a / 563267
• ZFINID: ZDB-GENE-050809-38
• Length: 853
• Species: Danio rerio
• Alignment Length: 879
• Identity: 185/879 - (21%)
• Similarity: 308/879 - (35%)
• Gaps: 307/879 - (34%)

  Fly   645 VIKVRR---PAPKV--------PVRNPNTSLSNPRQIEEEQTKPNGGKKDNLRGNSFAAENSSPE 698
            |.:|||   |.||.        |..|..::|        |..:||..||......|..|  ..|.
Zfish    65 VREVRRALMPPPKPLNIAGRGGPAPNRPSAL--------EIQRPNDNKKSPCPSPSSTA--LLPP 119

  Fly   699 EQEEESIYQPIWQFKTIEPVDQEIIE-ALP----------VEGEDEEDEDEEDDD------VDDE 746
            ..:..|   |:...:.:.|....... :||          ::||.::|:|.|..|      |.:|
Zfish   120 RDDRGS---PVSPTRHLPPAQMNTFPGSLPCFRAESPGSKLDGERDKDKDSERKDRGEKAAVQEE 181

  Fly   747 -EEDLGDYD---------ESLPSDADPDVMALQA------AAVFAAGVRHKLSTSTLTKRSKMMM 795
             .|:.||.|         :.|.|.:..::.:|.:      :.|:......|:|.|:
Zfish   182 LAEEGGDSDKNRIDSESGDELSSGSTDNLQSLGSGQGRPDSPVYTNLQEMKISQSS--------- 237

  Fly   796 PTPLPSPTASMDHGAWETDME-----FMYSRESKE------EADETLSLGSTVTNSTAT--LGS- 846
            ..||||.:....:|.|||..:     :.|:|.::|      .|.::|.......:.|.|  |.|
Zfish   238 TPPLPSSSPIHTNGDWETHKDQNGRHYYYNRSTQERTWKPPRARDSLPRKEEKHDMTDTEVLSSE 302

  Fly   847 ---ISSTGSSVTGQPKDTPKDLPADQQPSVVVHPILRNICIFYSQK---DPKKYSAIFY------ 899
               :||...|..|.|       |......:..|.....:|.:.::|   ...:...::|
Zfish   303 ENCLSSQSDSQYGSP-------PRGWSEEMDEHGHTLYVCDYTNEKWLRHTDERGRLYYYSADGS 360

  Fly   900 --------------DYHLSL----VHQRFMTRIRRPAPPP------------------------- 921
                          ..|..|    :|:......|.|.|.|
Zfish   361 RSEWELPKIGLKSQSNHTPLMPGDLHKTRSLDRRLPDPIPISRTQRHSIYSHETNDKLKQKFVKV 425

  Fly   922 -----PAQLATSNTTSLAPR-----SDDSGCSCEAEDSYNHQHNPTPAIP-----------KPLK 965
                 |.:..|..:....|:     |.||..||.:  |....|:|:....           |.::
Zfish   426 RQSFLPRRKTTLRSHPYFPQDTKTGSPDSDSSCPS--SPKPPHSPSEKCATLNMTKITEHGKKVR 488

  Fly   966 EEW---------------------------------ERAV-LAAGAV--AGKRGVAPRTGRKLRV 994
            :.|                                 |.:| |..|:|  |.|...:.:...:|:.
Zfish   489 KNWTSYWTVLQGSLLIFNKGQGGGSGWFGRDQKSSVEYSVDLKGGSVDWASKDKSSKKHVLELKT 553

  Fly   995 RSNARLLL-TDS---VLAWRETLQDVNCCEDEEDMIVPVTDILRAQQIQEDNEVQQTQQSTILQR 1055
            |....||| :||   |..|.:.|                |:.:.....:.|..:::
Zfish   554 RQGTELLLQSDSDGLVNDWHKAL----------------TEAIHTYMWESDEAIEE--------- 593

  Fly  1056 YKSVSIGNLLDLP---------GEDDKKSIKNRMRMKFAVNSNVFRINRSPKSEKKSRSR----- 1106
                      |:|         .|.|:|:.|....:|...:.:        .:|:|.:::
Zfish   594 ----------DMPESPENEKHDKEKDRKNSKKARDIKKTASMD--------NAEQKKKNKLVVLL 640

  Fly  1107 --RGQVNSL----YLDEQKYPLFAAPLSALELNMTDHPNVPRFVVDVCAYIEQPECIEQ------ 1159
              |..:.::    |:.:|   :|...||:  |...::..|||||     ::    ||||
Zfish   641 LGRPTLQAVKDKGYIKDQ---VFGCSLSS--LCQRENSTVPRFV-----WL----CIEQVEKNGL 691

  Fly  1160 --DGLYRASGNKVLVDELRKKLTH-----VYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQEAY 1217
              |||||.|||..::.:||..:.|     :.|.:|   :|||..|...|.|||||..||.|...:
Zfish   692 GVDGLYRVSGNLAIIQKLRFAVNHEEKIDLGDSKW---EDIHVTTGALKMFFRELPEPLFTYTFF 753

  Fly  1218 ERLGRSLNDDAAIERMSLAFD---DMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPC 1279
            .....::......:::....|   .:|.||..|::.|.:||.:|......|||.:.::|||:||.
Zfish   754 SDFISAIKMPDYKQKVQTVKDLMKKLPRPNHDTIQVLFKHLKKVIQHVDENRMTTQSVAIVFGPT 818

  Fly  1280 LL-----SANQIQLDIGRMNMLAKVLIENYDRIF 1308
            ||     :|| :.:.:...|.:.::::..||.||
Zfish   819 LLRPEIETAN-MAVHMVYQNQIVELILMEYDTIF 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1285	CDD:459875	54/164 (33%)
arhgap12a	XP_021336423.1	SH3_ARHGAP12	11..70	CDD:213003	2/4 (50%)
		SH3-WW_linker	67..233	CDD:435468	38/178 (21%)
		WW	252..278	CDD:459800	6/25 (24%)
		PRP40	253..>331	CDD:227435	19/84 (23%)
		PH_ARHGAP9-like	470..580	CDD:270053	20/125 (16%)
		RhoGAP_ARHGAP27_15_12_9	660..846	CDD:239868	61/200 (31%)