DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP18B and si:ch1073-416j23.1

DIOPT Version :9

Sequence 1:	NP_573352.2	Gene:	RhoGAP18B / 32898	FlyBaseID:	FBgn0261461	Length:	1317	Species:	Drosophila melanogaster
Sequence 2:	XP_695377.7	Gene:	si:ch1073-416j23.1 / 553480	ZFINID:	ZDB-GENE-100922-35	Length:	671	Species:	Danio rerio

Alignment Length:	555	Identity:	132/555 - (23%)
Similarity:	206/555 - (37%)	Gaps:	131/555 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   766 MALQAAAVFAAGVRHKLSTSTLTKRSKMMMPTPLPSPTASMDHGAWETDMEFMYS---RESKEEA 827
            :|..|..|.....|::|... :.||.|           |..|:...|..|:.:..   .:||..|
Zfish    91 VARAALEVKLKHARNQLDVE-IKKRYK-----------AEADYQCLERQMQLICDVLVHDSKSNA 143

  Fly   828 ---DETLSLGSTVTNSTATLGSISSTGSSVTGQPKDTPKDLPADQQPSVVVHPILRNICIFYSQK 889
               ||..|:          |.|.|..|:.|   |:...|.|....:.|.:.|
Zfish   144 CLNDEQRSM----------LTSFSHKGACV---PQHRGKRLSVIDESSFLSH------------- 182

  Fly   890 DPKKYSAIFYDY---HLSLVHQRFMTRI-------RRPAPPPPAQLATSNTTSLAPRSDDSGCSC 944
                 |.|.||.   .|.|....|:..:       ||.:..|...|.......::.||.|.
Zfish   183 -----SDISYDRTDDDLDLDSTAFVKPLKSRARERRRSSLGPVVSLPVPKRGRISGRSGDL---- 238

  Fly   945 EAEDSYNHQHNPTPAIPKPLKEEWERAVLAAGAVAGKRG-----------VAP-RTGRKLRVRSN 997
                          .:.:||::|.|..|:.|.....:.|           .|| ...|.||....
Zfish   239 --------------LVSRPLEKEIETTVVKASVSTPETGSQIHMVIDITQEAPEHPSRALRNEHF 289

  Fly   998 ARLLLTDSVLAWRETLQDVNCCEDEEDMIVPVTDILRAQQIQEDNEVQQT-QQSTILQRYKSVSI 1061
            :.:....||.|..|.:|.....|.|...:.|.  :|:......:..||.. ||.|:::....:..
Zfish   290 SSVAEQTSVWAHSEVIQAETMVEMEVSAVEPA--VLQDLTPTVEKTVQHVFQQKTVIRPETCLPC 352

  Fly  1062 GNLLDLPGEDDKKSIKNRMRM-KFAVNSNVFRINRSPK-----SEKKSRSRRGQVNSLYLDEQKY 1120
            |               .|:|. |.||.....|:...|:     .|:.|.:..|   |.:.:|:..
Zfish   353 G---------------KRIRFGKLAVKCRDCRVVSHPECKRLCPERCSPNAHG---SSHPNEETL 399

  Fly  1121 PLFAAPLSALELNMTDHPNVPRFVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLTHVYDP 1185
            ..||.         :..|.:|..:|. |.:..:...:|:.|:||..|.:..|.|||:|..:...|
Zfish   400 ESFAP---------STRPRIPSIIVQ-CVHEIERRGLEEKGIYRVPGGERQVKELREKYLYGKGP 454

  Fly  1186 RWL-KTDDIHTLTSLHKQFFRELTSPLIT---QEAYERLGRSLNDDAAIERMSLAFDDMPEPNRS 1246
            ..| |.|::|.:..|.|.|.|:|:.||||   ...:.......::|.::|.:.....::|:|||.
Zfish   455 LMLHKVDEVHAVCGLLKDFLRKLSEPLITFKLHRTFMEASEMADEDKSVETLLKTIRELPQPNRD 519

  Fly  1247 TLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLL 1281
            ||.||:.||.|| ..|...:|...||:.|:||.::
Zfish   520 TLAFLMLHLQRV-MQSPLCQMDLNNLSRVFGPTII 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	48/145 (33%)
si:ch1073-416j23.1	XP_695377.7	C1	336..384	CDD:237996	12/62 (19%)
si:ch1073-416j23.1	XP_695377.7	RhoGAP_MgcRacGAP	402..587	CDD:239847	51/163 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810