Protein Alignment RhoGAP18B and Arhgap32

DIOPT Version :10

• Sequence 1: NP_573352.2
• Gene: RhoGAP18B / 32898
• FlyBaseID: FBgn0261461
• Length: 1317
• Species: Drosophila melanogaster
• Sequence 2: XP_006510505.1
• Gene: Arhgap32 / 330914
• MGIID: 2450166
• Length: 2103
• Species: Mus musculus
• Alignment Length: 703
• Identity: 140/703 - (19%)
• Similarity: 251/703 - (35%)
• Gaps: 229/703 - (32%)

  Fly   702 EESIYQPIWQFKTIEPVDQEIIEALPVEGEDEEDED-----------EEDDDVDD-----EEEDL 750
            ::|::   |       :|.|.:..| .:|::||.|:           ||||.|.:     ...:.
Mouse    12 DDSVF---W-------LDCEGVTQL-TDGDEEEREESFRKMKSSIHSEEDDFVPELHRNVHPRER 65

  Fly   751 GDYDESLPS---DAD----PDVMALQAAAVFAAGVRHKLSTSTLTKRSKMMMPTPLPS------- 801
            .|::|:|.:   .||    |..:.|::....|         ||..|..|...|..|..
Mouse    66 PDWEETLSAMARGADVPEIPGDLTLKSCGSTA---------STKVKHVKKSTPPGLMGCDNIHRL 121

  Fly   802 --------PTASMDHGAWETDMEFMYSRES-KEEADETLSLGSTVTNSTATLGSISSTGSSVTGQ 857
                    ..|...|..:| ::||...:.| .||.:|.:..|.. :.....|..|:..|.|
Mouse   122 PFTKGHFPKMAECAHFHYE-NVEFGSIQLSLSEEQNEVMKNGCE-SKELVYLVQIACQGKS---- 180

  Fly   858 PKDTPKDLPADQQPSVVVHPILRNICIFYSQKDPKKYSAIFYDYHLSLVHQRFMTRIRRPAPPPP 922
                                       :..::..:.:..:....||.:..:||
Mouse   181 ---------------------------WIVKRSYEDFRVLDKHLHLCIYDRRF------------ 206

  Fly   923 AQLATSNTTSLAPRSDDSGCSCEAEDSYNHQHNPTPAIPKPLKEEWERAVLAAGAVAGKRGVAPR 987
                 |..|.| ||||      ..:||           |:.:.:.....:.....:||.:
Mouse   207 -----SQLTEL-PRSD------VLKDS-----------PESVTQMLTAYLSRLSTIAGNK----- 243

  Fly   988 TGRKLRVRSNARLLLTDSVLAWRETLQDVN--CCEDEEDMIVPVTDILRAQQIQEDNEVQQTQQS 1050
                         :.....|.|.|.....|  ...:|..:..|...                 .:
Mouse   244 -------------INCGPALTWMEIDNKGNHLLVHEESSINTPAVG-----------------AA 278

  Fly  1051 TILQRYK-------SVSIGNL---LDLPGEDDKKSIKNRMRMKFAVNSNVF------RINR---- 1095
            .:::||.       ::.:|::   :|:|    .|.:....|.|......:|      .||:
Mouse   279 HVIKRYTARAPDELTLEVGDIVSVIDMP----PKVLSTWWRGKHGFQVGLFPGHCVELINQKVPQ 339

  Fly  1096 -------SPKSEK------------KSRSRRGQVNSLYLDEQKYPLFAAPLSALELNMTDHPNVP 1141
                   .|.|:|            |||..:.::....:.:::  :|...|....||  ....||
Mouse   340 SVTNSVPKPVSKKHGKLITFLRTFMKSRPTKQKLKQRGILKER--VFGCDLGEHLLN--SGFEVP 400

  Fly  1142 RFVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLK---TDDIHTLTSLHKQF 1203
            :.:....|:||:...:  ||:||.||....:..||.:....:.|...|   ..|||::.||.|.:
Mouse   401 QVLQSCTAFIERYGIV--DGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLY 463

  Fly  1204 FRELTSPLITQEAYERLGRSLN---DDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASN 1265
            ||||.:||:|.:.||:...:::   |:..:.::......:|.|:..||.||:|||:.:|...:..
Mouse   464 FRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSIT 528

  Fly  1266 RMPSTNLAIVWGPCLLSANQIQ----------LDIGRMNMLAKVLIENYDRIF 1308
            .|.:.||||||.|.||.:.||:          :::...:::.:.::.:.|.:|
Mouse   529 NMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLF 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1285	CDD:459875	50/149 (34%)
Arhgap32	XP_006510505.1	PX_RICS	141..255	CDD:132831	29/198 (15%)
		SH3_ARHGAP32_33	277..330	CDD:212769	9/56 (16%)
		RhoGAP_CdGAP	382..576	CDD:239849	57/199 (29%)
		PHA03247	<1251..1633	CDD:223021