DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP18B and RhoGAP19D

DIOPT Version :9

Sequence 1:	NP_573352.2	Gene:	RhoGAP18B / 32898	FlyBaseID:	FBgn0261461	Length:	1317	Species:	Drosophila melanogaster
Sequence 2:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster

Alignment Length:	1350	Identity:	260/1350 - (19%)
Similarity:	452/1350 - (33%)	Gaps:	363/1350 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 SETPAKAPAPSTPTTPPTPPTKVKSRSLLGYSKSSAATLTRLFGSL--------KQLNRSSSLQR 178
            :.|||.:|...:.:...:.|....:.||.|.|:|.:.|.|...|..        :|..:....|:
  Fly   278 TSTPAGSPQSQSQSQSHSHPNTHHAPSLHGGSRSGSITSTASGGITVLSQPFYPQQQQQQQQQQQ 342

  Fly   179 RIFPRTPTTGSSSAGSLEIIHNVDEVFRTQETFDLQRICELKLEQQQLKGSQSDQHIYGRVREPE 243
            ...|.. |.||||....::.|.                    |.|.|    |..||:|      :
  Fly   343 HRHPAL-TGGSSSIDFGDMAHG--------------------LRQHQ----QQQQHLY------Q 376

  Fly   244 ESQSHKRERKRPRVSRIRLLQDESTSGSSSLYLNESICQWMTSLRRQVHHYDEGPWQQPKSVPAR 308
            :.|.|.:..:..:...:.:|...|.:.:.            |...|           ||||..:.
  Fly   377 QQQQHHQFMRANQPPNLTVLSASSATNTP------------TPTAR-----------QPKSATSH 418

  Fly   309 D---------PSSSAEESTVTLRRSTEESAKCADEQAKLVKDFKRKLQQKRAHNVEPEREQRRCA 364
            :         |||:|...:.:|...:|.|        .|:...:..::||......|.......|
  Fly   419 NQALYAVGAGPSSAAGSGSGSLSGGSENS--------DLMIRLRESIKQKEEFLKSPVPASMSSA 475

  Fly   365 ITANFVNDYLSALGEEKEAVQHQQVAAIEEHV--AVVAIAIQPQVS---VSLLRLMQSLALSASL 424
            .:.|......|:..:::...|||| .....|.  ..|.:.:.|..|   |.|.:..|........
  Fly   476 SSINGNQAQSSSPAQQQHLQQHQQ-HFFPSHTPPGGVQVVVPPPRSRHQVMLKQQQQQQQQHQQH 539

  Fly   425 HV-----------SVRGFLTA-------YDKSFSLWLWHQQQQQR------QQPPINGYRRRRAR 465
            ||           .|:...||       :.:.....|:||||.|:      :|..||. ..:.|:
  Fly   540 HVLGYDMYHSGGKLVQRSSTAPGSVCHQHQQQQQHHLYHQQQHQQLQQTQHRQVMINN-NAKYAK 603

  Fly   466 D-------SVVGVVGD-WRRRLPLFAFSFAGGNDRSVASASVSVSPAISESVDVCAAAASRRRAN 522
            |       ...||... :.|:|              |:..|....|....|::..|..:|...::
  Fly   604 DLDYFETLQETGVTNKVFERKL--------------VSHMSKGFDPFKPLSINTSALESSASTSS 654

  Fly   523 RSTRRRGTAIVREEGVC--------------GGESSTSSNNSKKNNNNNSNNNSGALMAA---PK 570
            .|    .|..|:::.|.              ..:.:|::.......::....:...|..|   |.
  Fly   655 TS----ATTTVKKQSVLYESLQQHPLAKYHQTQQQTTTTTTVDGQTSSRMELHKATLANATIDPV 715

  Fly   571 PNGEA------ERPSTNSNNNTINCSSNNNNDNISNNNNNHHTVDNESGINNNKNNDGNANCNVN 629
            |.|.:      ::|...|:..|:...:.::...|         ||:.||       .||.
  Fly   716 PVGSSKFVTLPDKPDKGSSVATLADIAESSAAAI---------VDSASG-------SGNV----- 759

  Fly   630 EQQQQQQQQPITQNCVIKVRRPAPKVPVRNPN--TSLSNPRQIEEEQTKPNGGKKDNLRGNSFAA 692
                .::.:|::.:...:.:      |:|..:  .:.:|......|.............|.:.|:
  Fly   760 ----VRRYKPLSSSSFDEGK------PMRRISYLRATNNETDFNAEAAAGGDAAATGASGPASAS 814

  Fly   693 ENSSPEEQEEESIYQPIWQFKTIEPVDQEIIEALPVEGEDEEDE-----DEEDDDVDDEEEDLGD 752
            ..||.......|...|     ...|....|...:||....|..:     :|..|...|.....|.
  Fly   815 AASSAPGPTPSSAPAP-----APAPAPLPISIPIPVAAVVEPQKTKSLVEEHPDPTYDVIGGTGG 874

  Fly   753 YDESLPSDADPDVMALQAAAVFAAGVRHKLSTSTLTKRSKMMMPTPLPSPTASMDHGAWETDMEF 817
            ..|.:.:   |:  .|:...:.|.|.|....:|.:  ||.:.:...|.......:..|:||::|.
  Fly   875 GHEFIET---PN--GLEDVRLSAHGSRRASMSSDM--RSSIHIDAELNGKYVPNELEAFETEIEI 932

  Fly   818 MYSRESKEEADETLSLGSTVTNSTATLGSISSTGSSVTGQPKDTPKDLPADQQPSVVVHPILRNI 882
            ..|..:.:...|..|...........|..|.|      |:...:..:         |:...:||.
  Fly   933 KSSCINGKRMSEYRSWRQVKLEIKGDLLRIYS------GRHAKSEHN---------VIELDIRNF 982

  Fly   883 CIFYSQKDPKKYSAIFYDYHLSLVHQRFMTRIRRPAPPPPAQLAT-SNTTSLAPRSD----DSGC 942
            ..|....|.|||                :.|::....|..|.||: .|..:|....|    .||.
  Fly   983 KFFDESMDKKKY----------------LIRMQSKPSPSGAHLASLGNELNLDEGHDKLLTSSGS 1031

  Fly   943 SCEAEDSYNHQHNPTPAIPKPLKEEWERAVLAAGAVAGKRGVAPRTGRKLRVRSNARLLLTDSVL 1007
            |...|.:.|                 ..:.|.|...:......|.|....:.:|:..:.....:|
  Fly  1032 SSANEPAAN-----------------AASALTASTSSSTCSSGPYTEILFKTKSSNEMKRLFGLL 1079

  Fly  1008 AWRETLQDVNCCEDE-----EDMIVPVTDILRAQQIQEDNEVQQTQQSTILQRYKSVSIGNLLDL 1067
            .|:::|   |..::|     :.:..|...:..|..:.:.........|:.|..:.    |.:.|.
  Fly  1080 QWKDSL---NYDDNEHQPQGKQLAEPQKTVASASYLDDVQGGASAADSSPLSSHS----GGIADA 1137

  Fly  1068 PGEDDKKSIKNRMRMKFAVNSNVFRINRSPKSEK------------KSRS------RRG------ 1108
            .|.....::.....:..|.:.::..:.::.||..            ||::      |||
  Fly  1138 SGSHHVSALPAAAAIVAATSDSISPVMKARKSSSHKHIPDKDLGSPKSKNWKDLLFRRGGSGSGG 1202

  Fly  1109 ---------------QVNSLYLDEQKYPLFAAPLSALELNMTDHPNVPRFVVDVCAYIEQPECIE 1158
                           |:.|:.:     ||.:.|:|.:      :..||. :|:||..|.:.:.:.
  Fly  1203 VSHHDLASPSACAAKQIGSIGV-----PLRSCPMSKV------NAYVPH-LVEVCTNIVETKGLG 1255

  Fly  1159 QDGLYRASGNKVLVDELRKKL--------THVYDPRWLKTDDIHTLTSLHKQFFRELTSPLITQ- 1214
            ..|:||..|||..:.||.:.:        :...|.||   :|::.::||.|.|.|.|...|:..
  Fly  1256 VVGIYRIPGNKAAISELSELVNTKDFQFESCASDDRW---EDVNVVSSLLKLFIRSLPDALMPAS 1317

  Fly  1215 ------EAYERLGRSLNDDAAIERMSL---AFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPST 1270
                  ||.::.|        :||:.|   ..:.:|.....|::.|||||.||:.....|||...
  Fly  1318 YYINFIEADKKFG--------LERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPK 1374

  Fly  1271 NLAIVWGPCLLSANQIQLDIGRMNM-----LAKVLIENYDRIFH----PD 1311
            ||||::||.::......|:....:|     :.::|:..||..|.    ||
  Fly  1375 NLAIIFGPSIIRTPNDTLETAVKDMKHQCRIVELLVTQYDYFFEGGSLPD 1424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	48/165 (29%)
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	59/218 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23176
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100