DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP18B and Racgap1

DIOPT Version :9

Sequence 1:	NP_573352.2	Gene:	RhoGAP18B / 32898	FlyBaseID:	FBgn0261461	Length:	1317	Species:	Drosophila melanogaster
Sequence 2:	NP_001101582.1	Gene:	Racgap1 / 315298	RGDID:	1305912	Length:	626	Species:	Rattus norvegicus

Alignment Length:	217	Identity:	67/217 - (30%)
Similarity:	101/217 - (46%)	Gaps:	22/217 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1121 PLFAAPLSALELNMTD-----HPNVPRFVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLT 1180
            ||...|:...|..:.|     .|.:|..||.....||| ..:.:.||||.||....|.||::|..
  Rat   337 PLVGTPVKIGEGMLADFVSQTSPMIPAIVVSCVNEIEQ-RGLTEAGLYRISGCDRTVKELKEKFL 400

  Fly  1181 HVYD-PRWLKTDDIHTLTSLHKQFFRELTSPLIT---QEAYERLGRSLNDDAAIERMSLAFDDMP 1241
            .|.. |...|.||||.:.||.|.|.|.|..||:|   .:|:.......::|.:...|..|..::|
  Rat   401 KVKTVPLLSKVDDIHAICSLLKDFLRNLKEPLLTFWLSKAFMEAAEITDEDNSTAAMYQAVSELP 465

  Fly  1242 EPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLS-----------ANQIQLDIGRMNM 1295
            :.||.||.||:.||.|| |.|.|.:|...|||.::||.:::           ...|:..:..:..
  Rat   466 QANRDTLAFLMIHLQRV-AQSPSTKMDVVNLAKIFGPTIVAHTVPNPDPVTMFQDIKRQLKVVER 529

  Fly  1296 LAKVLIENYDRIFHPDNERLVC 1317
            |..:.:|.:::....:.|.:.|
  Rat   530 LLSLPLEYWNQFMMVEQENMDC 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	57/162 (35%)
Racgap1	NP_001101582.1	C1	286..334	CDD:237996
Racgap1	NP_001101582.1	RhoGAP_MgcRacGAP	345..538	CDD:239847	62/194 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810