Protein Alignment RhoGAP18B and ABR

DIOPT Version :10

• Sequence 1: NP_573352.2
• Gene: RhoGAP18B / 32898
• FlyBaseID: FBgn0261461
• Length: 1317
• Species: Drosophila melanogaster
• Sequence 2: NP_001309770.1
• Gene: ABR / 29
• HGNCID: 81
• Length: 1118
• Species: Homo sapiens
• Alignment Length: 322
• Identity: 83/322 - (25%)
• Similarity: 135/322 - (41%)
• Gaps: 64/322 - (19%)

  Fly  1006 VLAWRETLQDVNCCEDEEDMIVPVTDILRAQQIQEDNEVQQTQQSTILQRYKSVSIGNLLDLPGE 1070
            :|.:.:........:|..::   |..|:...|||.|.:..:|:....          :::::.|
Human   826 ILCYEKCYDKTKVNKDNNEI---VDKIMGKGQIQLDPQTVETKNWHT----------DVIEMNG- 876

  Fly  1071 DDKKSIKNRMRMKFAVNSNVFRINRSPKSEKKSRSRRGQVNSLYLDEQKYPLFAAPLSALELNMT 1135
                 ||....|||  .|....:.|:|     |:.:.|             :|...:|.  :...
Human   877 -----IKVEFSMKF--TSRDMSLKRTP-----SKKQTG-------------VFGVKISV--VTKR 914

  Fly  1136 DHPNVPRFVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLTHVYDPR------WLKTDDIH 1194
            :...|| ::|..|....:...||:.|:||.||....:..|:.    |:|..      .|...||:
Human   915 ERSKVP-YIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKA----VFDANNKDILLMLSDMDIN 974

  Fly  1195 TLTSLHKQFFRELTSPLITQEAYERL--GRSLNDDAAIER-MSLAFDDMPEPNRSTLRFLIRHLT 1256
            .:....|.:||||..||:|...|...  |.:|:|.||.|. |......:|:||..|..||:.||.
Human   975 AIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLK 1039

  Fly  1257 RVAAASASNRMPSTNLAIVWGPCLLSANQIQ--------LDIGRMNMLAKVLIENYDRIFHP 1310
            |||.....|:|...|||.|:||.||..::::        .||...:::|:|.:..| .:.||
Human  1040 RVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLY-YLQHP 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1285	CDD:459875	53/152 (35%)
ABR	NP_001309770.1	Bcr-Abl_Oligo	3..65	CDD:430380
		PHA03321	<128..335	CDD:223041
		RhoGEF	351..541	CDD:238091
		PH_ABR	536..719	CDD:270172
		C2_ABR	765..885	CDD:176068	13/77 (17%)
		RhoGAP_Bcr	904..1099	CDD:239852	61/202 (30%)