DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP18B and Racgap1

DIOPT Version :9

Sequence 1:	NP_573352.2	Gene:	RhoGAP18B / 32898	FlyBaseID:	FBgn0261461	Length:	1317	Species:	Drosophila melanogaster
Sequence 2:	NP_001240737.1	Gene:	Racgap1 / 26934	MGIID:	1349423	Length:	628	Species:	Mus musculus

Alignment Length:	215	Identity:	66/215 - (30%)
Similarity:	99/215 - (46%)	Gaps:	22/215 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1121 PLFAAPLSALELNMTD-----HPNVPRFVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLT 1180
            ||...|:...|..:.|     .|.:|..||.....||| ..:.:.||||.||....|.||::|..
Mouse   339 PLVGTPVKIGEGMLADFVSQASPMIPAIVVSCVNEIEQ-RGLTEAGLYRISGCDRTVKELKEKFL 402

  Fly  1181 HVYD-PRWLKTDDIHTLTSLHKQFFRELTSPLIT---QEAYERLGRSLNDDAAIERMSLAFDDMP 1241
            .|.. |...|.||||.:.||.|.|.|.|..||:|   .:|:.......::|.:...|..|..::|
Mouse   403 KVKTVPLLSKVDDIHVICSLLKDFLRNLKEPLLTFWLSKAFMEAAEITDEDNSTAAMYQAVSELP 467

  Fly  1242 EPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLS-----------ANQIQLDIGRMNM 1295
            :.||.||.||:.||.|| :.|...:|...|||.|:||.:::           ...|:..:..:..
Mouse   468 QANRDTLAFLMIHLQRV-SQSPDTKMDIANLAKVFGPTIVAHTVPNPDPVTMFQDIKRQLKVVER 531

  Fly  1296 LAKVLIENYDRIFHPDNERL 1315
            |..:.:|.:::....|.|.:
Mouse   532 LLSLPLEYWNQFMMVDQENI 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	56/162 (35%)
Racgap1	NP_001240737.1	Tropomyosin	43..>108	CDD:395200
		Interaction with SLC26A8. /evidence=ECO:0000250	107..286
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..201
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..284
		C1_MgcRacGAP	286..339	CDD:410371	66/215 (31%)
		RhoGAP_MgcRacGAP	347..540	CDD:239847	61/194 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810