Protein Alignment RhoGAP18B and rga2

DIOPT Version :10

• Sequence 1: NP_573352.2
• Gene: RhoGAP18B / 32898
• FlyBaseID: FBgn0261461
• Length: 1317
• Species: Drosophila melanogaster
• Sequence 2: NP_594152.2
• Gene: rga2 / 2542682
• PomBaseID: SPAC26A3.09C
• Length: 1229
• Species: Schizosaccharomyces pombe
• Alignment Length: 1385
• Identity: 247/1385 - (17%)
• Similarity: 454/1385 - (32%)
• Gaps: 481/1385 - (34%)

  Fly   203 EVFRTQETFD-------LQRICELKLEQQQLKGSQSDQHIYGRVREPEESQSHK--RERKRPRVS 258
            |::..:|..|       .:|:.:|..:|:::        ||         :.||  .:.|:...|
pombe    18 EIWEDEEEEDNSGIVSQNERLMKLVNKQREI--------IY---------ELHKDLEKVKKDNTS 65

  Fly   259 -RIRLLQDESTSGSSSLYLNESICQWMTSLRRQVHHYDEGPWQQPKSVP------ARD-PSSSA- 314
             |:||.:.|||....|       .|...:...|...| ..|:::.|..|      ::| |::||
pombe    66 LRMRLSKYESTDSFPS-------SQPSRANSPQSDSY-SSPYEKGKLFPKISLKSSKDVPTASAH 122

  Fly   315 -------EESTVTL------RRSTEESAKCADEQAKLVKDFKRKLQQKRAHNVEPEREQRRCAIT 366
                   :.|:|:|      .::|:..|:..|..:.:.:. |..|..||:|. ..|.......:|
pombe   123 ISSSDHEKSSSVSLSALNNYNKTTDIKARSLDRLSDMTRP-KLLLNTKRSHR-SSEEPGASSPVT 185

  Fly   367 ANFVNDYLSALGEEKEAVQHQQVAAIEEHVAVVAIAIQPQVSVSLLRL--MQSLALSASLHVSVR 429
            :..:.|      .:||.:|..:..||:.:    :::.:....:..:|.  :..|:|:.|   |.|
pombe   186 SPILKD------SQKERIQALRNKAIKTY----SVSTESAERIDSIRSDNLSPLSLNTS---SFR 237

  Fly   430 GFLTAYDKSFSLWLWHQQQQQRQQPPINGYRRRRARDSVVGVVGDWRRRLPLFAFSFAGGNDRSV 494
            ..:|                  :..|.|
pombe   238 RPIT------------------KPTPFN------------------------------------- 247

  Fly   495 ASASVSVSPAISES-----------------VDVCAAAASRRRANRST-RRRGTAIVREEGVCGG 541
            :.:::|:.|..:.|                 :|:...     |||.|: ||:..:||:..|:
pombe   248 SDSNISIDPKDNNSNKQDHFAEIEDELRQQFLDIKVG-----RANASSPRRKSISIVKPHGI--- 304

  Fly   542 ESSTSSNNSKKNNNNNSNNNSGALMAAPKPNGEAERPSTNSNNNTINCSSNNNNDNISNNNNNHH 606
                   :|.|::.||.::.||...:..:         ..|.|..:...|..|:..|.|...|:.
pombe   305 -------SSPKHSTNNLSSKSGKFHSDFR---------VVSENVLLQARSETNSPIIENKEANNF 353

  Fly   607 TVDNESGINNNKNNDGNANCNVNEQQQQQQQQPITQNCVIKVRRPAPKVPVRNPNTSLSNPRQIE 671
            ...             .:|........:..:.|           |.|.:     ::|.:.||..:
pombe   354 LAP-------------TSNVPAYSTPARPTESP-----------PPPPI-----SSSSTTPRPDD 389

  Fly   672 EEQTKPNGGKKDNLRGNSFAAENSSPEEQEEESIYQPIWQFKTIEPVDQEIIEALPVEGEDEEDE 736
            :....|.|..:||   :|.:.:.:...:....|       |.|::..|.:|...     ....|.
pombe   390 KPSLPPRGLSEDN---DSLSLQKTGSSDTRRSS-------FSTLKIPDSDICFT-----RRRSDS 439

  Fly   737 DEEDDDVDDEEEDLGDYD--ESLPSDADPDVMALQAAAVFAAGVRHKLSTSTLTKRSKM--MMPT 797
            :.....:|.......|.|  ..:|:....:........:.:.|:.:..|..:...:||.  ..|:
pombe   440 NRTWTVIDPHHSQSFDNDILAEIPTSKLDNSSQKSPGKLSSKGLLNSFSPISPFSKSKSHNHHPS 504

  Fly   798 PLPSPTASMDHGAWETDMEFMYSRESKEEADETL-----------SLGS---------------- 835
            .....:.|...|:. ..::.:|:.:.....||:|           ||.|
pombe   505 SQVEKSTSNSKGSM-LPLDTLYNNKLSFRLDESLVRYLRFELMKTSLASLSPDFDCIGLQFVVGV 568

  Fly   836 ------------TVTNSTATLGSISSTGSSVT---GQP--------------------------- 858
                        .|.:.|.::|...|..:|..   |.|
pombe   569 SASSHLASQWKDEVWSFTRSIGECRSFATSFVLDIGAPPFPTLDWFTNDSSVIQNELLRRSVDTY 633

  Fly   859 ----------------------KDTPKD-------LPAD--QQPSVVVHPI-----------LRN 881
                                  .||.::       ||.:  |:..|::..|           |::
pombe   634 FRYIFQTDLKLEQRIKLLEFLSSDTLREYLHDVFFLPPEHAQKEGVLLKYIENSGLVSRYFYLKD 698

  Fly   882 ICIFYSQ------------KDPK--KYSA---IF------------YDYHLSLVHQRFMTRIR-- 915
            ..:::::            ||.:  :|:|   ||            .:|..:.|.|...|..|
pombe   699 NILYFAENRNSPVLGTIHLKDAQVNRYNANLPIFSIIDPPHEFLTGENYQSAFVIQEKQTETRTG 763

  Fly   916 -----------------------RPAPPPPAQLATSNTTSLAP-------------------RSD 938
                                   |..|...:.|..|..:.|:.                   ::|
pombe   764 TATVHVLLARDVEDQKSWLRAILRQVPGSTSPLNASPFSVLSSDFPGSSRYRDQSSPIRFYGKAD 828

  Fly   939 DSGCSCEAEDSYNHQHNPTPAIPKPLKEEWERAVLAAGAVAGKRGVAPR-----------TGRKL 992
            ....|.||..|.:...:|:|.:| |.:..   |..|..::.....::|:           ..|:.
pombe   829 SRPVSQEAILSQDISSSPSPVLP-PSENV---ASYADDSLVSNLTMSPKLRDSMEQVPLENHREF 889

  Fly   993 RVRSNARLLLTDSVLAWRETLQDVNCCEDEEDMIVPVTDILRAQQIQEDNEVQQTQQSTILQRYK 1057
            .:......|..||.......:.|....:|..:..|||.:|..::.     .:::|.|||.::.
pombe   890 EISDRVSELSFDSSTGSVLEIADTRRNQDAPEKHVPVIEIQSSRP-----SLEKTDQSTPVEL-- 947

  Fly  1058 SVSIGNLLDLPGEDDKKSIKNRMRMKF--------------------AVNSNVFRINRSPKSEKK 1102
                  |:|...::.:...| |.||||                    .:.:||.   .||.|...
pombe   948 ------LIDSHSQNSQNEEK-RSRMKFWAFPHHKAENYEQISDTNIPVIETNVM---LSPSSTTS 1002

  Fly  1103 SRSRRGQVNSLYLDEQKYPLFAAPLSALELNMTDHPN---VPRFVVDVCAYIEQPECIEQDGLYR 1164
            :...:..:      .:|..:|..||:. .:|::...|   :|..|.....|:|.....:::|:||
pombe  1003 AEPLQKHI------VRKSGIFGLPLNE-AVNISTQFNDSGLPIVVYRCIEYLESCRAEKEEGIYR 1060

  Fly  1165 ASGNKVLVDELRKKLTHVYDPRWLKTD---DIHTLTSLHKQFFRELTSPLI---TQEAYERLGRS 1223
            .||:...:..|:::.....|...|.:|   |:|.:..|.|.:.|.|.:.|:   ..:.:|.|...
pombe  1061 LSGSASTIKHLKEQFNEGVDYDLLSSDEEFDVHVIAGLLKLYLRNLPTNLLDTSMHKLFELLPNV 1125

  Fly  1224 LNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQIQL 1288
            .||.||:..:......:|..|.:.|..|:.||.|:.|....|:|...|:.||:.|.|    .|..
pombe  1126 PNDSAALGELCDVISKLPPENFALLDSLLHHLRRIIAFEKVNKMNIRNVCIVFSPTL----NIPS 1186

  Fly  1289 DIGRMNMLAKVLIENYDRIF 1308
            ||..|      ||.|||.||
pombe  1187 DIFMM------LILNYDHIF 1200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1285	CDD:459875	41/149 (28%)
rga2	NP_594152.2	PH-like	674..787	CDD:473070	15/112 (13%)
		RhoGAP_fBEM3	1016..1203	CDD:239865	57/196 (29%)