DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP18B and srgp-1

DIOPT Version :9

Sequence 1:	NP_573352.2	Gene:	RhoGAP18B / 32898	FlyBaseID:	FBgn0261461	Length:	1317	Species:	Drosophila melanogaster
Sequence 2:	NP_001255566.1	Gene:	srgp-1 / 178079	WormBaseID:	WBGene00006406	Length:	1059	Species:	Caenorhabditis elegans

Alignment Length:	265	Identity:	63/265 - (23%)
Similarity:	107/265 - (40%)	Gaps:	27/265 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1057 KSVSIGNLLDLPGEDDKKSIKNRMRMKFAVNSNVFRINRSPKSEKKSRSRR-GQVNSLYLDEQKY 1120
            ||.|:|:..:..|.              ....|....|.....|::|::|| |.:.:...|::..
Worm   471 KSASVGSASERNGS--------------FTTENGGSQNHHLLEERRSKARRIGGIVTKSPDDRPR 521

  Fly  1121 P-LFAAPLSALELNMTDHPNVPRFVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLTHVYD 1184
            | ||...|.  |........:|..|....||:.: ..:...||:|.||::..::..|:......|
Worm   522 PKLFGGSLD--EYVEATGEEIPLLVQSAIAYLSR-YSLRNQGLFRVSGSQSEINRFREAYERGED 583

  Fly  1185 PRWLKTD--DIHTLTSLHKQFFRELTSPLITQEAYERL---GRSLNDDAAIERMSLAFDDMPEPN 1244
            ......|  |.::...:.|.:||||..|:.....:|:.   .:|.:....:.|.......:|..:
Worm   584 LFQYLDDGSDANSAAGVLKLYFRELREPIFPIFMFEQFCDCAKSESPTEFVRRARELVSKLPVSH 648

  Fly  1245 RSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQIQLDI---GRMNMLAKVLIENYDR 1306
            ...||||...|:.:...:..|.|...||||.:||.||...:.:..:   ..:|.|.:.||.:.|.
Worm   649 VLLLRFLFAFLSHLCEFADENMMEPHNLAICFGPTLLPIPEGKDQVFYHNYVNELVRNLIIHADD 713

  Fly  1307 IFHPD 1311
            :|..|
Worm   714 VFPRD 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	38/152 (25%)
srgp-1	NP_001255566.1	F-BAR_srGAP	60..300	CDD:153340
srgp-1	NP_001255566.1	RhoGAP	523..710	CDD:383032	46/189 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I3724
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960