Protein Alignment RhoGAP18B and cyk-4

DIOPT Version :10

• Sequence 1: NP_573352.2
• Gene: RhoGAP18B / 32898
• FlyBaseID: FBgn0261461
• Length: 1317
• Species: Drosophila melanogaster
• Sequence 2: NP_499845.1
• Gene: cyk-4 / 176815
• WormBaseID: WBGene00000875
• Length: 681
• Species: Caenorhabditis elegans
• Alignment Length: 685
• Identity: 137/685 - (20%)
• Similarity: 223/685 - (32%)
• Gaps: 255/685 - (37%)

  Fly   666 NPRQIEEEQTKPNGGKKDNLRGNSFAAENSSPEEQEEESIYQPIWQFKTI-EPV----DQEIIEA 725
            |..:..|:|.      ||.::...|   ||..:|..:        |||.: ||:    .:.:.:.
 Worm   108 NVYETREKQL------KDAMKNGIF---NSLTKEDRD--------QFKFLHEPLVRTYSKRVQQR 155

  Fly   726 LPVEGEDEEDEDEEDDDVDDEEEDLGD-YDESLPSDADPDVMALQAAAVFAAGVRHKLSTSTLT- 788
            .|...||.:| ||:|.:||.:|  .|| ::|.:......:|....||.....|.|...|...:|
 Worm   156 HPHLMEDTQD-DEDDSEVDYDE--TGDSFEEVIHLRNGREVRRSSAAGNAVGGKRRSASAHAITA 217

  Fly   789 ------KRSKMMMPTPLPSPTASMDHGAWETDMEFMYSRESKEEADETLSLGSTVTNSTATLGSI 847
                  .||::|        ||::|                 ||.:|    |.|
 Worm   218 AANSKRSRSRVM--------TATID-----------------EEPNE----GGT----------- 242

  Fly   848 SSTGSSVTGQPKDTPKDLPADQQPSVVVHPILRNICIFYSQKDPKKYSAIFYDYHLSLVHQRFMT 912
                                                       |.|
 Worm   243 -------------------------------------------PPK------------------- 245

  Fly   913 RIRRPAPPPPAQLATSNTTSLAPRSDDSGCSCEAEDSYNHQHNPTPAIPKPLKEEWERAVLAAGA 977
            |.|.....|..::.|:.||:......:|          ..|:...|.:  .|..:..|..|:.|:
 Worm   246 RCRDDGSTPHQEMTTTTTTTTTTTIHNS----------RAQNQDPPRV--SLHRQLTRRSLSCGS 298

  Fly   978 VAGKRGVAPRTGRKLRVRSNARLLLTDSVL----------AWRE-TLQDV--------------- 1016
            :........:|...:.:..:: .:||.|.|          ||.. |.:|:
 Worm   299 IPSCDQTPGQTTNNIGLGMSS-AILTKSTLDIRTLKRGTPAWTNGTTRDIAMRPHTFIEAGIKAM 362

  Fly  1017 -NCCEDEEDMIVPVTDILRAQQIQEDNEVQQTQQSTILQRYKSVSIGNLLDLPGEDDKKSIKNRM 1080
             .|     |.......:..:.:.::.::|...            |..|.|.||.....|::
 Worm   363 RKC-----DKCATALKLATSMKCRDCHQVVHR------------SCCNKLHLPCIPRPKTM---- 406

  Fly  1081 RMKFAVNSNVFRINRSPKSEKKSRSRRGQVNSLYLDEQKYPLFAAPLSALELNMTD-----HPNV 1140
                          .:|||     :.||               |.| .|.|..:.|     .|.:
 Worm   407 --------------MTPKS-----ALRG---------------AKP-GAGEFRLQDFCTSAKPMI 436

  Fly  1141 PRFVVDVCAYIEQPECIEQDGLYRASGN----KVLVDELRKKLTHVYDPRWLKTDDIHTLTSLHK 1201
            |..|:. |....:...:.|:|:||..|.    .||:||||.|..    |. :...|:..:|...|
 Worm   437 PAAVIH-CVVALEARGLTQEGIYRVPGQVRTVNVLLDELRSKTV----PN-VGLHDVEVITDTLK 495

  Fly  1202 QFFRELTSPLITQEAYERLGRSLN---DDAAIERMSL--AFDDMPEPNRSTLRFLIRHLTRVAAA 1261
            :|.|:|..|||.:.:.:.|..:.|   .|....|::|  ...::|:.||.||.:|..|..:|.|.
 Worm   496 RFLRDLKDPLIPRTSRQELIVAANLYSTDPDNGRLALNRVICELPQANRDTLAYLFIHWRKVIAQ 560

  Fly  1262 SASNRMPSTNLAIVWGPCLL----SANQIQLDIGR 1292
            |:.|:|....:|.:..|.::    ..:|.|...||
 Worm   561 SSRNKMNCEAMARMVAPAVMGHPVKQSQSQAIAGR 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1285	CDD:459875	44/156 (28%)
cyk-4	NP_499845.1	DR0291	40..>120	CDD:441187	4/17 (24%)
		C1	350..403	CDD:412127	8/69 (12%)
		RhoGAP_MgcRacGAP	418..615	CDD:239847	53/185 (29%)