Protein Alignment RhoGAP18B and pac-1

DIOPT Version :9

• Sequence 1: NP_573352.2
• Gene: RhoGAP18B / 32898
• FlyBaseID: FBgn0261461
• Length: 1317
• Species: Drosophila melanogaster
• Sequence 2: NP_498877.4
• Gene: pac-1 / 176201
• WormBaseID: WBGene00015418
• Length: 1605
• Species: Caenorhabditis elegans
• Alignment Length: 1136
• Identity: 215/1136 - (18%)
• Similarity: 366/1136 - (32%)
• Gaps: 354/1136 - (31%)

  Fly   445 HQQQQQRQQPPINGYRRRRARDSVV-----------GVVGDWR-RRLPLFAFSFAGGNDRSVASA 497
            ||||.|.|      .||:....::|           .:.|.|: |..|          .|...|.
 Worm    74 HQQQYQPQ------LRRKANTTNIVDVSSQVPSARNAIYGSWQDRHRP----------TRLYGSQ 122

  Fly   498 SVSVSPAISESVDVCAAAASRRRANRSTRRRGTAIVREE----GVCGGESST-SSNNSKK----- 552
            .||.|..:.:...:....||....|.||....|..:|.|    |..|...|| ...||:.
 Worm   123 LVSSSSTLPKYDQLYCNTASPLTGNGSTNTIATTGIRREPPEYGNVGRSVSTWQVTNSEHRPSLQ 187

  Fly   553 ------------------------NNNNNSNNNS---GALMAAPKPNGEAERPST-----NSNNN 585
                                    .|.:.|..:|   |.|.....|..:...|:.     :.:.:
 Worm   188 AGWLKSSRPLARGALSPAAYFRDLENRHGSGASSPIVGGLSVVAVPITQRHAPTAGLAPISDDIS 252

  Fly   586 TINCSSNNNNDNISNNNNNHHTVDNESGINNNKNNDGNANCNVNEQQQQQQQQPITQNCVIKVRR 650
            |...|.:..|..::|.::     |..||...::|....|:.....|:.
 Worm   253 TSKVSLDTENQQLNNEDS-----DKISGSALSRNTPRQASFMAAMQRH----------------- 295

  Fly   651 PAPKVPVRNPNTSLSN---PRQIEEEQTKPNGGKKDNLRGNSFAAENSSPEEQEEESIYQPI--- 709
                 |::..:||:.:   ....||:||.....|:|    .|....:..|||.:|.| ..||
 Worm   296 -----PLKESSTSIESNGGGTNTEEDQTVSATSKED----PSEDTGHDDPEETQEIS-ETPIRRS 350

  Fly   710 ----------WQFKTIEPVDQEII-----------EALPVEGEDEED--EDEEDDDVDDEEEDLG 751
                      ...:::..:|.|.:           ||....|.....  ::..||.:......:.
 Worm   351 RNRNASLRNRQSSRSLGGLDFEKLRMGTARVGDSNEATAENGTSSSSSRKNSRDDGLTSSPTTVA 415

  Fly   752 ------DYDESLPSDADPDVMALQAAA---VFAAGVRHKLSTSTLT---KRSKMMMPTPLP---- 800
                  ....|:.:..:....|:.|||   |.|...|...|.|::.   ..:..|:....|
 Worm   416 GPVFTTSSTSSISTSGEASSTAVAAAAAGSVAATTSRQTSSNSSVDSNHNEAMKMIRRARPKSYV 480

  Fly   801 -SPTASMDHGAWETDMEFMYSRESKEEADETLS--------LGSTVTNSTATLGSISSTGSSVTG 856
             :.:|||:.....:.: ....:.|....|.|.|        :|||::....:.|:.|:|.::.:.
 Worm   481 LATSASMNEDVLSSSI-IANEQSSSISHDTTTSGRELPSSLMGSTISMEMRSGGASSATTTTTSN 544

  Fly   857 QPKDTPKDLPADQQPSVVVHPILRNICIFYSQKDPK----------------------------- 892
            ..:.|.:.|.|...|:  .|.:.|.|.:|.|.|...
 Worm   545 SGQQTSRSLNAPHPPA--THRLQRFIALFNSSKTSDGSGEHKKSRMKRSRTSLPASRFALPGTIL 607

  Fly   893 -----------KYSAI----------FYDYHLSLVHQRFMTRIRRPAPPPPAQLATSNTTSLAPR 936
                       |:..|          :.|....|..:.....:..||      ..|..|..|...
 Worm   608 QRDGVARQTWVKHQEIALGKSGKRNNWEDRWAVLCRRSLYLCVESPA------YTTEKTIELGSH 666

  Fly   937 SDDSGCSCEAE-------DSYNHQHNPTPAIPKPLKE------------EWERAV-------LAA 975
            :....|:...:       .|::.|.:....:.:...|            .|...:       :|.
 Worm   667 TRVDVCNAIVDIAYDWLSSSFSKQRHVVRIVTQNRSEHLIELNTESEMLSWISVLQSSSEDGIAT 731

  Fly   976 GAVAGKRGVAPRTGR-KLRVRSNARLLLTDSVLAWRETLQDVNCCEDEEDMIVPVTDILRAQQIQ 1039
            |:...:..:: .||| .....||:..||.:|        |.:.............::.|.:|...
 Worm   732 GSSVDENELS-TTGRHNNNAVSNSSALLHNS--------QSIASLASSSCSTATTSEFLNSQHTL 787

  Fly  1040 EDNEVQQTQQSTILQRYKSVSIGNLLDLP-----------GEDDKKSIKNRMRM----------- 1082
            :..:.|||.|.. .|....:|.|.:..||           .....::.|||:.|
 Worm   788 QQQQQQQTNQKH-QQTVNELSAGIVSHLPTSKSFGGLSTTASSTTENAKNRLIMHRYIAKNSQLQ 851

  Fly  1083 --------------------KFAVNSNVFRINRS--------------------PKSE---KKSR 1104
                                ..|..|:.|..:.|                    |||.   |||:
 Worm   852 SPTANKKMETDPSTVPSSSQTMATTSSSFHHHSSQAGPSRDIENGEAPTATATTPKSGRKWKKSK 916

  Fly  1105 SRR----GQVNSLYLDEQKYPLFAAPLSALELNMTDHP------NVPRFVVDVCAYIEQPECIEQ 1159
            :.:    |..:......|:.....||...|.:.:.|.|      :|| .:|..|..:.:...::.
 Worm   917 AAKQGSGGGSSGSSSGSQQQGAAGAPQPVLGVRIADCPTGSCEDHVP-MIVQACVCVIETYGMDT 980

  Fly  1160 DGLYRASGNKVLVDELRKKLTH------------VYDPRWLKTDDIHTLTSLHKQFFRELTSPLI 1212
            .|:||..||...|:.|::.|::            ..||||   .|::.::||.|.|.|:|..||:
 Worm   981 VGIYRIPGNTAAVNALKESLSNRGFDSVDLSKVESLDPRW---RDVNVVSSLLKMFLRKLPEPLL 1042

  Fly  1213 TQEAY------ERLGRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTN 1271
            |.:.|      .|:....|   .:.::......:|.|:..||||||.||:.:...|..|:|...|
 Worm  1043 TDKLYPFFIDANRISTHHN---RLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRN 1104

  Fly  1272 LAIVWGPCLL--SANQIQLDIGRMNMLAKVL 1300
            ||:::||.::  |.:.:...:..|:...|::
 Worm  1105 LALMFGPSIVRPSDDNMATMVTHMSDQCKII 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	47/167 (28%)
pac-1	NP_498877.4	PH_ARHGAP21-like	613..728	CDD:269955	14/120 (12%)
		PH	617..726	CDD:278594	14/114 (12%)
		RhoGAP_ARHGAP21	945..1146	CDD:239860	53/198 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010