Protein Alignment RhoGAP18B and pac-1

DIOPT Version :10

• Sequence 1: NP_573352.2
• Gene: RhoGAP18B / 32898
• FlyBaseID: FBgn0261461
• Length: 1317
• Species: Drosophila melanogaster
• Sequence 2: NP_498877.4
• Gene: pac-1 / 176201
• WormBaseID: WBGene00015418
• Length: 1605
• Species: Caenorhabditis elegans
• Alignment Length: 1142
• Identity: 215/1142 - (18%)
• Similarity: 367/1142 - (32%)
• Gaps: 366/1142 - (32%)

  Fly   445 HQQQQQRQQPPINGYRRRRARDSVV-----------GVVGDWR-RRLPLFAFSFAGGNDRSVASA 497
            ||||.|.|      .||:....::|           .:.|.|: |..|          .|...|.
 Worm    74 HQQQYQPQ------LRRKANTTNIVDVSSQVPSARNAIYGSWQDRHRP----------TRLYGSQ 122

  Fly   498 SVSVSPAISESVDVCAAAASRRRANRSTRRRGTAIVREE----GVCGGESST-SSNNSKK----- 552
            .||.|..:.:...:....||....|.||....|..:|.|    |..|...|| ...||:.
 Worm   123 LVSSSSTLPKYDQLYCNTASPLTGNGSTNTIATTGIRREPPEYGNVGRSVSTWQVTNSEHRPSLQ 187

  Fly   553 ------------------------NNNNNSNNNS---GALMAAPKPNGEAERPST-----NSNNN 585
                                    .|.:.|..:|   |.|.....|..:...|:.     :.:.:
 Worm   188 AGWLKSSRPLARGALSPAAYFRDLENRHGSGASSPIVGGLSVVAVPITQRHAPTAGLAPISDDIS 252

  Fly   586 TINCSSNNNNDNISNNNNNHHTVDNESGINNNKNNDGNANCNVNEQQQQQQQQPITQNCVIKVRR 650
            |...|.:..|..::|.::     |..||...::|....|:.....|:.
 Worm   253 TSKVSLDTENQQLNNEDS-----DKISGSALSRNTPRQASFMAAMQRH----------------- 295

  Fly   651 PAPKVPVRNPNTSLSN---PRQIEEEQTKPNGGKKDNLRGNSFAAENSSPEEQEEESIYQPI--- 709
                 |::..:||:.:   ....||:||.....|:|    .|....:..|||.:|.| ..||
 Worm   296 -----PLKESSTSIESNGGGTNTEEDQTVSATSKED----PSEDTGHDDPEETQEIS-ETPIRRS 350

  Fly   710 ----------WQFKTIEPVDQEII-----------EALPVEGEDEED--EDEEDDDVDDEEEDLG 751
                      ...:::..:|.|.:           ||....|.....  ::..||.:......:.
 Worm   351 RNRNASLRNRQSSRSLGGLDFEKLRMGTARVGDSNEATAENGTSSSSSRKNSRDDGLTSSPTTVA 415

  Fly   752 ------DYDESLPSDADPDVMALQAAA---VFAAGVRHKLSTSTLT---KRSKMMMPTPLP---- 800
                  ....|:.:..:....|:.|||   |.|...|...|.|::.   ..:..|:....|
 Worm   416 GPVFTTSSTSSISTSGEASSTAVAAAAAGSVAATTSRQTSSNSSVDSNHNEAMKMIRRARPKSYV 480

  Fly   801 -SPTASMDHGAWETDMEFMYSRESKEEADETLS--------LGSTVTNSTATLGSISSTGSSVTG 856
             :.:|||:.....:.: ....:.|....|.|.|        :|||::....:.|:.|:|.::.:.
 Worm   481 LATSASMNEDVLSSSI-IANEQSSSISHDTTTSGRELPSSLMGSTISMEMRSGGASSATTTTTSN 544

  Fly   857 QPKDTPKDLPADQQPSVVVHPILRNICIFYSQKDPKKYSAIFYDYHLSLVHQRFMTRIRRPAPPP 921
            ..:.|.:.|.|...|:  .|.:.|.|.:|.|.|....          |..|::  :|::|.....
 Worm   545 SGQQTSRSLNAPHPPA--THRLQRFIALFNSSKTSDG----------SGEHKK--SRMKRSRTSL 595

  Fly   922 PAQ--------------------------------------------------------LATSNT 930
            ||.                                                        ..|..|
 Worm   596 PASRFALPGTILQRDGVARQTWVKHQEIALGKSGKRNNWEDRWAVLCRRSLYLCVESPAYTTEKT 660

  Fly   931 TSLAPRSDDSGCSCEAE-------DSYNHQHNPTPAIPKPLKE------------EWERAV---- 972
            ..|...:....|:...:       .|::.|.:....:.:...|            .|...:
 Worm   661 IELGSHTRVDVCNAIVDIAYDWLSSSFSKQRHVVRIVTQNRSEHLIELNTESEMLSWISVLQSSS 725

  Fly   973 ---LAAGAVAGKRGVAPRTGR-KLRVRSNARLLLTDSVLAWRETLQDVNCCEDEEDMIVPVTDIL 1033
               :|.|:...:..:: .||| .....||:..||.:|        |.:.............::.|
 Worm   726 EDGIATGSSVDENELS-TTGRHNNNAVSNSSALLHNS--------QSIASLASSSCSTATTSEFL 781

  Fly  1034 RAQQIQEDNEVQQTQQSTILQRYKSVSIGNLLDLP-----------GEDDKKSIKNRMRM----- 1082
            .:|...:..:.|||.|.. .|....:|.|.:..||           .....::.|||:.|
 Worm   782 NSQHTLQQQQQQQTNQKH-QQTVNELSAGIVSHLPTSKSFGGLSTTASSTTENAKNRLIMHRYIA 845

  Fly  1083 --------------------------KFAVNSNVFRINRS--------------------PKSE- 1100
                                      ..|..|:.|..:.|                    |||.
 Worm   846 KNSQLQSPTANKKMETDPSTVPSSSQTMATTSSSFHHHSSQAGPSRDIENGEAPTATATTPKSGR 910

  Fly  1101 --KKSRSRR----GQVNSLYLDEQKYPLFAAPLSALELNMTDHP------NVPRFVVDVCAYIEQ 1153
              |||::.:    |..:......|:.....||...|.:.:.|.|      :|| .:|..|..:.:
 Worm   911 KWKKSKAAKQGSGGGSSGSSSGSQQQGAAGAPQPVLGVRIADCPTGSCEDHVP-MIVQACVCVIE 974

  Fly  1154 PECIEQDGLYRASGNKVLVDELRKKLTH------------VYDPRWLKTDDIHTLTSLHKQFFRE 1206
            ...::..|:||..||...|:.|::.|::            ..||||   .|::.::||.|.|.|:
 Worm   975 TYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLSKVESLDPRW---RDVNVVSSLLKMFLRK 1036

  Fly  1207 LTSPLITQEAY------ERLGRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASN 1265
            |..||:|.:.|      .|:....|   .:.::......:|.|:..||||||.||:.:...|..|
 Worm  1037 LPEPLLTDKLYPFFIDANRISTHHN---RLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVN 1098

  Fly  1266 RMPSTNLAIVWGPCLL--SANQIQLDIGRMNMLAKVL 1300
            :|...|||:::||.::  |.:.:...:..|:...|::
 Worm  1099 KMECRNLALMFGPSIVRPSDDNMATMVTHMSDQCKII 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1285	CDD:459875	47/163 (29%)
pac-1	NP_498877.4	PH_ARHGAP21-like	613..728	CDD:269955	8/114 (7%)
		RhoGAP_ARHGAP21	945..1146	CDD:239860	53/198 (27%)