Protein Alignment RhoGAP18B and Chn1

DIOPT Version :10

• Sequence 1: NP_573352.2
• Gene: RhoGAP18B / 32898
• FlyBaseID: FBgn0261461
• Length: 1317
• Species: Drosophila melanogaster
• Sequence 2: XP_006498620.2
• Gene: Chn1 / 108699
• MGIID: 1915674
• Length: 541
• Species: Mus musculus
• Alignment Length: 564
• Identity: 120/564 - (21%)
• Similarity: 183/564 - (32%)
• Gaps: 206/564 - (36%)

  Fly   914 IRRPAPPPPAQLATSNTTSLAPRSDDSGCSCEAEDSYNHQHNPTPAIPKPLKEEWERAVLAAGAV 978
            :|....||          ||.|....||....|.          ||.|      |.|.|.|.|.:
Mouse    15 VRGERRPP----------SLRPAGRASGPPARAR----------PAGP------WRRQVRARGGL 53

  Fly   979 AGKRGV----------------------APRTGRKLRVR--------------SNARLLLTDS-- 1005
            .|.||.                      |||.....|.|              |...|.|.|:
Mouse    54 PGCRGPGAPLANARVTFPRCGPPRPPRHAPRAAAPPRCRLPAAAGARSAGRRGSTMALTLFDTDE 118

  Fly  1006 --VLAWRETL----------QDVNC-CE------------------DEEDMIVPVTD---ILRAQ 1036
              ...|:..|          :.|.| ||                  :|.|.::.|.:   ::|..
Mouse   119 YRPPVWKSYLYQLQQEAPHPRRVTCTCEVENRPKYYGREYHGMISREETDQLLSVAEGSYLIRES 183

  Fly  1037 QIQEDNEVQQTQQSTILQRYKSVSIGNLL-----DLPGEDDKKSIKNRMR--------------- 1081
            |       :|....|:..|:.|.:....|     ...||...:||.:.:.
Mouse   184 Q-------RQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEY 241

  Fly  1082 -MKFAVNS-----NVFRINRSPK-----------------------SEKKSRSRRGQVNSLYLDE 1117
             .|..:|.     ....:||.|.                       |||:..:.||.....|...
Mouse   242 IAKMTINPIYEHIGYTTLNREPAYKQHMAVLKETHDEKEATGQDGVSEKRVHTFRGPHWCEYCAN 306

  Fly  1118 QKYPLFAAPLSALELNMTDHPN----VPR-----------------------------FVVDVCA 1149
            ..:.|.|..:...:..:..|..    ||.                             .|||:|.
Mouse   307 FMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHITKRPMVVDMCI 371

  Fly  1150 YIEQPECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTD-------DIHTLTSLHKQFFREL 1207
            ...:...:..:||||.||...|:::::.    .:|....|.|       ||:.:|...|.:||:|
Mouse   372 REIESRGLNSEGLYRVSGFSDLIEDVKM----AFDRDGEKADISVNMYEDINIITGALKLYFRDL 432

  Fly  1208 TSPLITQEAYERL---GRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPS 1269
            ..||||.:||.:.   .:.::.|..:|.:..|...:|..:..|||:|:.||.||......|.|.:
Mouse   433 PIPLITYDAYPKFIESAKIMDPDEQLETLHEALRSLPPAHCETLRYLMAHLKRVTLHEKENLMSA 497

  Fly  1270 TNLAIVWGPCLLSANQIQ-----LDIGRMNMLAKVLIENYDRIF 1308
            .||.||:||.|:.:.::.     .||....::.::||:|.|.:|
Mouse   498 ENLGIVFGPTLMRSPELDPMAALNDIRYQRLVVELLIKNEDILF 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1285	CDD:459875	49/182 (27%)
Chn1	XP_006498620.2	SH2_a2chimerin_b2chimerin	150..236	CDD:198215	14/92 (15%)
		C1_CHN	291..339	CDD:410356	8/47 (17%)
		RhoGAP_chimaerin	348..541	CDD:239837	54/196 (28%)