DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP18B and chn2

DIOPT Version :9

Sequence 1:	NP_573352.2	Gene:	RhoGAP18B / 32898	FlyBaseID:	FBgn0261461	Length:	1317	Species:	Drosophila melanogaster
Sequence 2:	XP_002933428.2	Gene:	chn2 / 100496459	XenbaseID:	XB-GENE-950874	Length:	467	Species:	Xenopus tropicalis

Alignment Length:	186	Identity:	57/186 - (30%)
Similarity:	91/186 - (48%)	Gaps:	20/186 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1139 NVPR-FVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKT---DDIHTLTSL 1199
            |.|| .|||:|....:...::.:||||.||....:::::.......|...:.:   .||:.:|..
Frog   286 NTPRPMVVDMCIQEIEGRGLKSEGLYRVSGFTEHIEDVKMSFDRDGDRADISSTLYPDINIITGA 350

  Fly  1200 HKQFFRELTSPLITQEAYERL---GRSLNDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAA 1261
            .|.:||:|..|:||.:.|.:.   .:..|.|..:|.:..|...:|..:..|||||:.||.:||..
Frog   351 LKLYFRDLPIPVITYDTYYKFMEASKISNADERLEAIHEALMLLPPAHYETLRFLMIHLKKVALN 415

  Fly  1262 SASNRMPSTNLAIVWGPCLL---------SANQIQLDIGRMNMLAKVLIENYDRIF 1308
            ...|.|.|.||.||:||.|:         |.|    |:.....:.::||:|.|.:|
Frog   416 EKDNLMGSENLGIVFGPTLMRPPEENALASLN----DMRHQKQIVQLLIQNEDVLF 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	50/163 (31%)
chn2	XP_002933428.2	SH2_a2chimerin_b2chimerin	52..138	CDD:198215
		C1_betaCHN	209..269	CDD:410407
		RhoGAP_chimaerin	274..467	CDD:239837	56/184 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910