DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP18B and arhgap9

DIOPT Version :9

Sequence 1:	NP_573352.2	Gene:	RhoGAP18B / 32898	FlyBaseID:	FBgn0261461	Length:	1317	Species:	Drosophila melanogaster
Sequence 2:	XP_012813282.2	Gene:	arhgap9 / 100494875	XenbaseID:	XB-GENE-1013568	Length:	789	Species:	Xenopus tropicalis

Alignment Length:	885	Identity:	190/885 - (21%)
Similarity:	311/885 - (35%)	Gaps:	318/885 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   629 NEQQQQQQQQP----ITQNCVIKVRRPAPKVPVRNPNTSLSNPRQIEEEQTKPNGGKKDNL-RGN 688
            |.::...|::|    |.::|:.|    ||                         ||...|| .|:
Frog    12 NWKKSSLQKKPVVLRIQKSCMFK----AP-------------------------GGSTVNLNEGD 47

  Fly   689 SFAAENSSPEEQEEESIYQPIWQFKTIEP-------------VDQEIIEALPVEGEDEEDEDEED 740
            :......|.::.         ||.:.:|.             :.|.|:|    :.:::..:|:|.
Frog    48 TLVVLKKSDKDW---------WQVRKVEESETTKPFHAPSSYISQLILE----KNKEQRSKDKEG 99

  Fly   741 -----------------DDVDDEEEDLGDYD-ESLPSDADPDVMALQAAAV-------------- 773
                             ....|::..|..|. |||.....|.....::|:.
Frog   100 IKHFTRSQENLLFFSSVPSTMDDQSYLKFYSGESLTPTIPPSSKHKKSASFSLSSSWHGYFPKCE 164

  Fly   774 -----FAAGVRHKLST----------STL--TKRSKMMMPTPLPSPTASMDHGAWETDME----- 816
                 |...|..|:|.          |.|  .|..|.:.|:|...|...:|:  ||...:
Frog   165 KEKSPFYKSVSEKVSLANPMQENPVYSNLEEMKMGKGIPPSPTHPPIHMIDN--WECHFDPLSGR 227

  Fly   817 -FMYSRESKEE---------------AD---------------------------ETLSLGSTVT 838
             |..:.|:||:               ||                           |.:|..:...
Frog   228 NFYINTETKEKTWKPPRKTRDHTPGRADTLPKDVESSGEYDKYQIPRTPFMQVKGEQISDPTLEQ 292

  Fly   839 NSTATLGSISSTGS----SVTGQ--------PK--DTPKDLPADQQPSVVVHPILRNICIFYSQK 889
            :|.:.|.|..|.||    |..||        ||  .|...:.::.:.|...|  .||:    ||.
Frog   293 HSISPLSSSQSFGSLHRISNDGQLDGEKPLLPKLTYTKSMILSNSRVSKANH--RRNL----SQS 351

  Fly   890 DPKKYSAIFYDYHLSLVHQRFMTRIRRP------APPPPAQLATSNTTSLAPRSDDSGCSCEAE- 947
            :.:.||....:.|            |.|      .|....:.:..|.|.:|    :.|...:..
Frog   352 NAENYSDTTAELH------------RVPVVTVLDVPHEVEKASQLNKTKIA----EGGRKLKKNW 400

  Fly   948 ---------DSYNHQHNPTPAIP---KPLKEEWERAVLAAGA-------VAGKRGVAPR---TGR 990
                     :|.....:|...:|   ||...:.|.:|...||       ::.|:.|...   ||.
Frog   401 SASWVVLTGNSLMFYKDPKVLVPSGWKPSNSKPESSVDLRGATIDSTQEMSSKKNVIHLRMVTGN 465

  Fly   991 KLRVRSNARLLLTDSVLAWRETLQDVNCCEDEEDMIVPVTDILRAQQIQEDNEVQQTQQSTILQR 1055
            :..::|:..||:.:    |.:.||.|....|.|:   |:.||                   ||:|
Frog   466 EYLLQSDKDLLIQE----WYDALQRVIERLDREN---PLDDI-------------------ILRR 504

  Fly  1056 YKSVSIGNLLDLPGEDDKKSIKNRMRMKFAVNSNVFRINRSPKSEKKSRSRRG------------ 1108
            ..||.:   ||..|.:::..:|.:...||:::    .::.:|..:||.|:|..
Frog   505 AGSVEV---LDGSGGEEESPLKTKDNRKFSLS----WVSSNPSDKKKVRTRLKKLLVRRPPLQTL 562

  Fly  1109 QVNSLYLDEQKYPLFAAPLSALELNMTDHPNVPRFVVDVCAYIE--QPECIEQDGLYRASGNKVL 1171
            |...|..|:    :|...|.|  |...::..||:|   ||..||  ....:|.||:||.:||...
Frog   563 QEKGLIKDQ----VFGCRLDA--LCHRENSTVPKF---VCMCIEAVNERGLEADGIYRVNGNLAT 618

  Fly  1172 VDELR----KKLTHVYDPRWL---------KTD-------DIHTLTSLHKQFFRELTSPLITQEA 1216
            :.:||    ::.....|.|:|         |.|       |:|.:|...|.|||||..|||....
Frog   619 IQKLRFIVDRERAVTTDGRYLFPEQLSQEEKLDLSTSDWEDVHVITGALKMFFRELPEPLIPFSM 683

  Fly  1217 YERLGRSL---NDDAAIERMSLAFDDMPEPNRSTLRFLIRHLTRVAAASASNRMPSTNLAIVWGP 1278
            :|:...::   :.|..||.:......:||||..||:.::.||.||...|.:|||.:.|:.||:||
Frog   684 FEQYVEAVQIPDLDERIETIKDLVSTLPEPNHDTLKHMLSHLKRVMEHSETNRMTTQNIGIVFGP 748

  Fly  1279 CL----------LSANQIQLDIGRMNMLAKVLIENYDRIF 1308
            .|          ::||.:.     .|.:.:..:..|:.:|
Frog   749 TLMRPEKELFSNIAANMVY-----QNQVVEHFLTYYEELF 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1289	CDD:279014	58/182 (32%)
arhgap9	XP_012813282.2	SH3	33..80	CDD:418401	12/84 (14%)
		WW	215..243	CDD:395320	7/29 (24%)
		PH_ARHGAP9-like	379..490	CDD:270053	24/118 (20%)
		RhoGAP_ARHGAP27_15_12_9	573..777	CDD:239868	64/213 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000816
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000