Protein Alignment RhoGAP18B and arhgap21

DIOPT Version :10

• Sequence 1: NP_573352.2
• Gene: RhoGAP18B / 32898
• FlyBaseID: FBgn0261461
• Length: 1317
• Species: Drosophila melanogaster
• Sequence 2: XP_031759009.1
• Gene: arhgap21 / 100037846
• XenbaseID: XB-GENE-1011028
• Length: 1952
• Species: Xenopus tropicalis
• Alignment Length: 1433
• Identity: 282/1433 - (19%)
• Similarity: 476/1433 - (33%)
• Gaps: 474/1433 - (33%)

  Fly    74 SGGVVSTPPPPP-----PPPLSTISGESSNIYENICDLCRGIYSDNERCRCQRSETPAKAPAPST 133
            ||...:.|.|||     ..|.:::..:...:..:...|.:           |:|..|.:     |
 Frog   200 SGNAQNIPEPPPICYPRTKPAASVMAQPVEVPPSGTSLTK-----------QQSSRPVR-----T 248

  Fly   134 PTT------------PPTPPTKVKSRSLLGYSKSSAATLTRLFGSLKQLNRSSSLQRRIFPRTPT 186
            .||            ||:|...|||.:.:.....:..|:  :..|.|.::.||:...|..|
 Frog   249 ATTQPDRSYRVEIQVPPSPTDIVKSNTAVCVCNEAVRTV--ILPSEKVVDLSSNRTNRAGP---- 307

  Fly   187 TGSSSAGSLEIIHNVDEVFRTQETFDLQRICELKLEQQQLKGSQSDQHIYGRVREPEESQSHKRE 251
                       :|..:||                      :...:|..:..|...|..|..
 Frog   308 -----------LHRTEEV----------------------RYGLADPSMLKRTTSPPSSTP---- 335

  Fly   252 RKRPRVSRIRLLQDESTSGSSSLYLNESICQWMTSLRRQVHHYDEGPWQQPKSVPARDPSSSAEE 316
             ..|.|...|...:....|....|...|  :.|.|.|                     ||.:.|.
 Frog   336 -SVPMVPASRQFDNAGVIGKPPSYGGHS--ESMFSTR---------------------PSQAEES 376

  Fly   317 STVTLRRSTEESAKCAD-EQAKLVKDF--KRKLQQKRAHNVEPEREQRRCAITANFVNDYLSAL- 377
            .:.|...::..|.:..| ...|..|::  .|::|......::...:..|.|  :....||...|
 Frog   377 PSPTNHYASPGSHQQIDWRNYKTYKEYIDNRRMQMYGCRTIQERLDSLRAA--SQNTTDYDQMLP 439

  Fly   378 ----GE-EKEAVQHQQVAAIEEHVAVVAIAIQ-PQVSVSLLR-----LMQSLALSA------SLH 425
                |: .:.:..|.:|..          ::| .|.|||..|     ||:....||      ||.
 Frog   440 NRSSGQVRRRSTSHDRVPQ----------SVQMRQRSVSQERLEDPVLMKEWPRSASQDTLTSLT 494

  Fly   426 VSVRG-------FLTAYDKSFSLWLWHQQQ--QQRQQPPINGYRRRRARDSVVGVVGDWRRRLPL 481
            |:.|.       :||. .:.|..::...|.  :|:......|:..   :|...|:....|:.
 Frog   495 VAPRNHRSESWDYLTR-KEDFDQFIVDTQSNGEQKHNYKWTGFTE---QDDQRGIYEIPRQH--- 552

  Fly   482 FAFSFAGGNDRSVASASVSVSPAISESVDVCAAAASRRRANRSTRRRGTAIVREEGVCGGESSTS 546
               ||    ..|:.|.:.:::|....|               .:||.||.::.............
 Frog   553 ---SF----HMSLRSPNYTMAPLPYPS---------------DSRRAGTRVLAPARPLQKVHPDL 595

  Fly   547 SNNSKKNNNNNSNNNSGALMAAPKPNGEAERPSTN-------SNNNTINCSSNNNNDNISNNNNN 604
            .......|..||       ..:|.|     ||:.:       |.:|::...:...:...|
 Frog   596 KTIQPTRNFQNS-------YRSPHP-----RPAVSERLVFPISKSNSVKIPATYASKPYS----- 643

  Fly   605 HHTVDNESGINNNKNNDGNANCNVNEQQ----------QQQQQQPITQNCV------IKV----- 648
             .:|.:|.||             |.:|:          |..|::|.|::.:      :|.
 Frog   644 -PSVGSEDGI-------------VKDQKAVNYIHVSGPQNFQRKPQTESALGFQLDSLKTSTSAS 694

  Fly   649 -RRPAPKVPVRNPNTSLSNPRQIEEEQTK-PNGGKKDNLRGNSFAA--------ENSSPEEQEEE 703
             ..||...|.:....|.:..:.::.::|: |.....|:   ||...        |..||.:|..:
 Frog   695 SSSPAHTKPAKQVKHSTATSQNVDGKKTQSPEANASDS---NSVLTSIDQVVLREKPSPGQQTSQ 756

  Fly   704 SIYQPIWQFKTIEPVDQEIIEALPVEGED-------------------EEDEDEEDDDVDDEEED 749
            .|.||.:.|...:           |||..                   |:.:....|...|....
 Frog   757 PIRQPSYIFAVSD-----------VEGASDTTCWLPNDARREVHIKRIEQKKASGSDSPGDSLAS 810

  Fly   750 LGDYDESLPSDADPDVMALQAAAVFAAGVRHKLSTSTLTKRSKMMMPTPLPSPTA---------S 805
            :...||......|.::..:.|:||.:..|: .|.|.|          |..||||:         |
 Frog   811 IPFIDEPTSPSIDHEIANIPASAVISISVQ-PLPTIT----------TVPPSPTSPVPLIRRHFS 864

  Fly   806 MDHGAWETDMEFMYSR------------ESKEEADETLSLGSTVTNSTATLGSISSTGSSVTGQP 858
            .||.:....:..:.|:            :.|:|...:|..||::....|.....||..|.   ..
 Frog   865 HDHDSIRPSILEVNSKTERSKSCDEGLDDYKDEGKLSLKQGSSLKGIKARENVPSSEDSE---SR 926

  Fly   859 KDTPKDLPAD-----------------------QQPSVVVHPILRNICIFYSQKDPKKYSAIFYD 900
            ||:..|:.:|                       .:|...::.:||...: |.|||.|:.|.
 Frog   927 KDSSSDVFSDSNKEGFLYFRQLTTEKGKRVSGSMRPWKQMYVVLRGSAL-YLQKDKKEQSG---- 986

  Fly   901 YHLSLVHQRFMTRIRRPAPPPPAQLATSNTTSLAPRSDDSGCSCEAEDSYNHQHNPTPAIPKPLK 965
             |.|             |.....||...|             .|..:.||:
 Frog   987 -HSS-------------AQSDEEQLIGIN-------------GCLIDISYS-------------- 1010

  Fly   966 EEWERAVLAAGAVAGKRGVAPRTGRK--LRVRSNARLLL-----TDSVLAWRETLQDVNCCEDEE 1023
                                 .|.||  .|:.::.|..|     .|.:|||.:.:|:.....||:
 Frog  1011 ---------------------ETKRKNVFRLTTSDREFLFQAEDRDDMLAWIKAIQENGNLNDEQ 1054

  Fly  1024 DMIVPVTD----ILRAQQIQEDNEV-----QQTQQS--------TILQRYKSVSIGNLLDLPGED 1071
                  ||    :|.:::|:|.|.:     .:::||        :|.|.:::......|..| ..
 Frog  1055 ------TDQASRVLISKRIKEYNTMMSSSSNKSEQSPKPSRQTLSIRQPFRATKPEGKLQSP-HS 1112

  Fly  1072 DKKSIKNRMRMKFAVNSNVFRINRSPKSEKKSRSRRGQVNSLYLDEQKYPLFAAPLS--ALELNM 1134
            .|:..:.|:..|..:         ||..:|.|..|          ..|.|....|.:  ...:.:
 Frog  1113 PKQESERRLFSKDDI---------SPPKDKGSWRR----------IMKKPFEKKPTTGGTFGVRL 1158

  Fly  1135 TD----HPN--VPRFVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLT------HVYDPRW 1187
            .|    |.|  || .:||||..:.:...:|..|:||..||...:..::::|.      .:.|.:|
 Frog  1159 DDCPPAHNNKYVP-LIVDVCCKLVEDRGLETTGIYRVPGNNAAISSMQEELNKGSTDIDIQDDKW 1222

  Fly  1188 LKTDDIHTLTSLHKQFFRELTSPLITQEAYERLGRSLNDDAAIERMSL---AFDDMPEPNRSTLR 1249
               .|::.::||.|.|||:|..||.|.|.|.....:...:..:||:..   ...|:|:.:..||:
 Frog  1223 ---RDLNVISSLLKSFFRKLPDPLFTNEKYNDFIEANRTEDPVERLKTLKRLILDLPDHHYETLK 1284

  Fly  1250 FLIRHLTRVAAASASNRMPSTNLAIVWGPCLLSANQIQLDIGRMNM-----LAKVLIENYDRIFH 1309
            :|..||..||..|..|:|...|||||:||.|:..::..:.....:|     :.:.||:.:|..|.
 Frog  1285 YLSAHLKAVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQQHDWFFS 1349

  Fly  1310 PDN 1312
            .::
 Frog  1350 EES 1352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP18B	NP_573352.2	RhoGAP	1141..1285	CDD:459875	49/152 (32%)
arhgap21	XP_031759009.1	PDZ_ARHGAP21_23-like	55..166	CDD:467238
		PH_ARHGAP21-like	938..1051	CDD:269955	29/179 (16%)
		RhoGAP_ARHGAP21	1153..1348	CDD:239860	57/198 (29%)