DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7423 and MTPN

DIOPT Version :9

Sequence 1:	NP_573347.1	Gene:	CG7423 / 32894	FlyBaseID:	FBgn0030982	Length:	124	Species:	Drosophila melanogaster
Sequence 2:	NP_665807.1	Gene:	MTPN / 136319	HGNCID:	15667	Length:	118	Species:	Homo sapiens

Alignment Length:	115	Identity:	52/115 - (45%)
Similarity:	79/115 - (68%)	Gaps:	2/115 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EDIIWTIKNGVYDEVERIFLAGSLNVNDQM-GVRFPLHYAADFGQLKLLEFFVRIGAEVDRKDKY 71
            ::.:|.:|||..||| :.::|...:||..: |.|.|||||||.|||::|||.:..||:::..||:
Human     4 KEFMWALKNGDLDEV-KDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKH 67

  Fly    72 GITPLLAAIWEGHTRCVEFLLRMGASRTERTPEGQSYAEAAEQEDIRRLL 121
            .|||||:|::|||..||:.||..||.:|.:.|:|.:..||.:.:.|:.||
Human    68 HITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALL 117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7423	NP_573347.1	Ank_2	10..96	CDD:289560	42/86 (49%)
		ANK	12..121	CDD:238125	50/109 (46%)
		ANK repeat	37..69	CDD:293786	17/32 (53%)
		ANK repeat	71..101	CDD:293786	16/29 (55%)
MTPN	NP_665807.1	ANK 1	2..30		9/26 (35%)
		Ank_2	6..97	CDD:403870	45/91 (49%)
		ANK repeat	6..32	CDD:293786	10/26 (38%)
		ANK 2	34..66		17/31 (55%)
		ANK repeat	34..65	CDD:293786	17/30 (57%)
		ANK 3	67..99		16/31 (52%)
		ANK repeat	67..97	CDD:293786	16/29 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4214
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40607
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4787
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1435166at2759
OrthoFinder	1	1.000	-	-		FOG0007179
OrthoInspector	1	1.000	-	-		otm41510
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4613
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.870