Protein Alignment CG43759 and arhgef10lb

DIOPT Version :10

• Sequence 1: NP_001259697.1
• Gene: CG43759 / 32889
• FlyBaseID: FBgn0264090
• Length: 900
• Species: Drosophila melanogaster
• Sequence 2: XP_021329341.1
• Gene: arhgef10lb / 567649
• ZFINID: ZDB-GENE-090313-222
• Length: 1369
• Species: Danio rerio
• Alignment Length: 575
• Identity: 104/575 - (18%)
• Similarity: 172/575 - (29%)
• Gaps: 202/575 - (35%)

  Fly    48 VHSAPPGVSGGS---------IASGGSMSMRHGQRVVASAHQHPSQMTLNHGGMGHNHNHGMGMA 103
            ||.|..|.|..|         :||.|..|  |||..:.|.:: |:..::....:|       ...
Zfish   899 VHCALLGFSAASTSLPQGYLWVASRGDDS--HGQVEIFSLNR-PTPRSVKSFSLG-------SQV 953

  Fly   104 MGMGHNHGHAAATLGHPHSHSHNNSSGSSSHGHVGS---------HLIFPDDMDS-----IEFCM 154
            :.:.:        :..|.:.....:..|.....:|:         :::....:|:     :.||
Zfish   954 LCLEY--------ITEPSTEEEQETQASEVPSKIGNTICVGLLDGNIMVYGSVDTAAQCLLTFC- 1009

  Fly   155 PAAPSSSSASSQNGLGDQLLLGSSHGEAFTERRRRGHS----RRSNH----------KMDVEQQV 205
              .|..........||:.|..|.|:|:.....|:.|..    ....|          .:.::|.|
Zfish  1010 --NPERCHVLCLKHLGNFLFAGLSNGKVAVYNRKSGEGLWDPDSCRHVVIGYAPILKLLRIDQCV 1072

  Fly   206 KWSRKNIAATME-------RFEPTPN-------------------TQSSS----STSSLDYGFAA 240
            ..|..|..:.:|       .||..|:                   ::.||    .|.:|::....
Zfish  1073 WASCANQVSVIEGSSLRTQSFEVHPDPMVSVTHMVRAGGGVWMAFSEGSSLRLFHTETLEHLQEI 1137

  Fly   241 GVMTPSGSSATASHGGGASNPSLHVAFNGGGGAVGGGSSAASGASGVSGSGAAAAAAPFNHVYSY 305
            .:.|||      ::...|..|:|.|:          ......|...|..:.......|...:
Zfish  1138 NISTPS------AYFSSAQKPNLCVS----------SLLICQGLLWVGTAQGIIVTLPVPRL--- 1183

  Fly   306 AYYEPGAAKCHTNVPAAQGAGPGQGQAHQVQSKSPPRNSIRALLAKS------FRSKSS------ 358
                       ..:|...|.|.....||        ...:..|||.|      |..:.|
Zfish  1184 -----------EGIPKITGKGMTSLNAH--------NGPVEFLLATSSVLPQDFLKRDSATDNVD 1229

  Fly   359 TNHGGQSTSSSPSAEERDRHTYTTRYGTTENLYEEVSDQKIRKVLSDNRIASGSSV-GNVKEEQR 422
            :|.||....::.|:||..:....|..|          :.|.:.||....:.|.|.: |.|...|
Zfish  1230 SNSGGDEKEATNSSEESLQQADATSQG----------EAKSKGVLLQYHLRSTSRLPGKVLTAQ- 1283

  Fly   423 RVQHNHFRVLDELNLSLEALIMPPTPPDVSPSHAMG-----------ADEPSTSMSAGAVGGSAV 476
                                  |...|| |..|.:.           :|:|..
Zfish  1284 ----------------------PEETPD-SAQHTVEHSLEDGSIYELSDDPEV------------ 1313

  Fly   477 SSVVAGPTKTAQRPRRGGLLGGAA---GAGGTSNSSSASHASLENLSSTLNSMEL 528
              .|.||..|::...|...:..||   |..|....:::|| |.|:..:||...:|
Zfish  1314 --WVRGPGTTSKEAGRREKVTSAAVISGGKGFRRLANSSH-SAESSENTLMVWQL 1365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43759	NP_001259697.1	None
arhgef10lb	XP_021329341.1	RhoGEF	418..602	CDD:238091
		PH_19	626..773	CDD:465965
		WD40_2	881..1369	CDD:465964	104/575 (18%)
		WD40 repeat	911..949	CDD:293791	9/40 (23%)
		WD40 repeat	953..1009	CDD:293791	4/63 (6%)
		WD40 repeat	1015..1047	CDD:293791	8/31 (26%)
		WD40 repeat	1052..1094	CDD:293791	6/41 (15%)
		WD40 repeat	1100..1138	CDD:293791	4/37 (11%)