DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7378 and EPM2A

DIOPT Version :9

Sequence 1:	NP_001285421.1	Gene:	CG7378 / 32888	FlyBaseID:	FBgn0030976	Length:	235	Species:	Drosophila melanogaster
Sequence 2:	NP_005661.1	Gene:	EPM2A / 7957	HGNCID:	3413	Length:	331	Species:	Homo sapiens

Alignment Length:	203	Identity:	42/203 - (20%)
Similarity:	68/203 - (33%)	Gaps:	68/203 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 YSSSIGDRYSPHYYQSPSRLETSEQTT-------GRQLQRVLHYSMAPSRALPGLRRAECAIHDV 69
            |...||     |:.::.......:.||       |.|   .:|||
Human   122 YCLPIG-----HWIEATGHTNEMKHTTDFYFNIAGHQ---AMHYS-------------------- 158

  Fly    70 DCDEVYPGIYIGDAAAAKNKTYLRL---MGITHVLN---------AAEGC-RYGQVDTGHSYYRD 121
               .:.|.|::|..........::|   :|||.|:|         .:.|| ||.:..|..:..:
Human   159 ---RILPNIWLGSCPRQVEHVTIKLKHELGITAVMNFQTEWDIVQNSSGCNRYPEPMTPDTMIK- 219

  Fly   122 MPSIRRSHKDCVFRYMGFPMVDAPTTDISRYFYV-----ASKFIDSAISSGGKILVHCLVGMSRS 181
                       ::|..|...:..||.|:|....|     |...:.:.:..|..:.|||..|:.||
Human   220 -----------LYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRS 273

  Fly   182 ATCVLAYL 189
            ...|..:|
Human   274 TAAVCGWL 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7378	NP_001285421.1	DUSP3-like	71..227	CDD:350365	31/137 (23%)
EPM2A	NP_005661.1	CBM20_laforin	1..129	CDD:99881	3/11 (27%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:25544560, ECO:0007744\|PDB:4RKK	103..107
		PTPc	158..304	CDD:304379	32/159 (20%)
		Glucan phosphatase signature motif CXAGXGR. /evidence=ECO:0000305\|PubMed:25544560, ECO:0000305\|PubMed:26231210	266..272		2/5 (40%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:25544560, ECO:0007744\|PDB:4RKK	267..272		1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900