DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SdhBL and SDH2

DIOPT Version :9

Sequence 1:	NP_001285420.1	Gene:	SdhBL / 32887	FlyBaseID:	FBgn0030975	Length:	437	Species:	Drosophila melanogaster
Sequence 2:	NP_013059.1	Gene:	SDH2 / 850685	SGDID:	S000003964	Length:	266	Species:	Saccharomyces cerevisiae

Alignment Length:	235	Identity:	157/235 - (66%)
Similarity:	189/235 - (80%)	Gaps:	5/235 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 PRLKTFEIYRWKPGD---QPQTQTYEVDLEQCGAMVLDALIKIKNEMDPTLTFRRSCREGICGSC 246
            ||||||::|||.|.:   :|..|:|:|||..||.||||||:|||:|.|.||||||||||||||||
Yeast    31 PRLKTFKVYRWNPDEPSAKPHLQSYQVDLNDCGPMVLDALLKIKDEQDSTLTFRRSCREGICGSC 95

  Fly   247 AMNINGTNTLACVSSIDQNESKCCRIYPLPHLYVVRDLVPDMSQFYDQYRSIQPWLQRKDLKREA 311
            ||||.|.|||||:..|||||||..:||||||:::|:|||||::.||.||:||||:|||....::
Yeast    96 AMNIGGRNTLACICKIDQNESKQLKIYPLPHMFIVKDLVPDLTNFYQQYKSIQPYLQRSSFPKD- 159

  Fly   312 GTAQYLQSVDDRLVLDGLYECILCACCQTSCPSYWWNSNKYLGPAVLMQAYRWVIDSRDEATEQR 376
            || :.|||::||..|||||||||||||.|||||||||..:|||||||||||||:|||||:||:.|
Yeast   160 GT-EVLQSIEDRKKLDGLYECILCACCSTSCPSYWWNQEQYLGPAVLMQAYRWLIDSRDQATKTR 223

  Fly   377 LDFLKDPWKLYRCHSIMNCTNTCPKHLNPARAIIQLKQLL 416
            ...|.:...|||||:|||||.||||.|||..||.::|:.|
Yeast   224 KAMLNNSMSLYRCHTIMNCTRTCPKGLNPGLAIAEIKKSL 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SdhBL	NP_001285420.1	sdhB	189..417	CDD:235652	153/231 (66%)
		Fer2_3	189..293	CDD:289830	71/106 (67%)
		Fer4_8	330..403	CDD:289926	54/72 (75%)
SDH2	NP_013059.1	PLN00129	31..264	CDD:215067	157/235 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343850
Domainoid	1	1.000	137	1.000	Domainoid score	I1066
eggNOG	1	0.900	-	-		E1_COG0479
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I346
Isobase	1	0.950	-	0	Normalized mean entropy	S140
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46869
orthoMCL	1	0.900	-	-		OOG6_100664
Panther	1	1.100	-	-	O	PTHR11921
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1851
TreeFam	1	0.960	-	-
	11	10.700