Protein Alignment SdhBL and SDHB

DIOPT Version :10

• Sequence 1: NP_573340.1
• Gene: SdhBL / 32887
• FlyBaseID: FBgn0030975
• Length: 437
• Species: Drosophila melanogaster
• Sequence 2: NP_002991.2
• Gene: SDHB / 6390
• HGNCID: 10681
• Length: 280
• Species: Homo sapiens
• Alignment Length: 252
• Identity: 169/252 - (67%)
• Similarity: 204/252 - (80%)
• Gaps: 4/252 - (1%)

  Fly   174 AKSAPPVKAKKPRLKTFEIYRWKP---GDQPQTQTYEVDLEQCGAMVLDALIKIKNEMDPTLTFR 235
            ::.|....|..||:|.|.||||.|   ||:|..|||||||.:||.||||||||||||:|.|||||
Human    26 SRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFR 90

  Fly   236 RSCREGICGSCAMNINGTNTLACVSSIDQNESKCCRIYPLPHLYVVRDLVPDMSQFYDQYRSIQP 300
            |||||||||||||||||.|||||...||.|.:|..:||||||:||::|||||:|.||.||:||:|
Human    91 RSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEP 155

  Fly   301 WLQRKDLKREAGTAQYLQSVDDRLVLDGLYECILCACCQTSCPSYWWNSNKYLGPAVLMQAYRWV 365
            :|::||..:| |..|||||:::|..|||||||||||||.|||||||||.:||||||||||||||:
Human   156 YLKKKDESQE-GKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWM 219

  Fly   366 IDSRDEATEQRLDFLKDPWKLYRCHSIMNCTNTCPKHLNPARAIIQLKQLLVGLKKK 422
            |||||:.||:||..|:||:.|||||:|||||.||||.|||.:||.::|:::...|:|
Human   220 IDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEK 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SdhBL	NP_573340.1	PLN00129	183..416	CDD:215067	165/235 (70%)
SDHB	NP_002991.2	PLN00129	5..271	CDD:215067	167/245 (68%)
		Interaction with SDHAF1. /evidence=ECO:0000269|PubMed:26749241	146..218		52/72 (72%)