DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Flacc and Zc3h13

DIOPT Version :9

Sequence 1:	NP_573339.1	Gene:	Flacc / 32886	FlyBaseID:	FBgn0030974	Length:	1150	Species:	Drosophila melanogaster
Sequence 2:	XP_036014719.1	Gene:	Zc3h13 / 67302	MGIID:	1914552	Length:	1752	Species:	Mus musculus

Alignment Length:	1579	Identity:	334/1579 - (21%)
Similarity:	515/1579 - (32%)	Gaps:	658/1579 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SLRRYKKAARHSATHSSSSDST-------SDSDSGSSSYSSTDSEQGVGGVGVGVGVPGGAGGPG 65
            |::|:..:.|...|.|.|...|       |.|...:...||...:|.          |.....|.
Mouse   363 SIQRHSPSPRRKRTPSPSYQRTLTPSLRRSASPYPTHCLSSPQRKQS----------PPRHRSPM 417

  Fly    66 GSGSVHGHPHT---HGHGHHPRSAERHHR-KKKSSRRGGSSSGD-----EPSSSRRKRDKRDHVQ 121
            .....|.|..|   |...|..|...|..| ::|.:|....|..|     ||..||.:||.||  :
Mouse   418 REKGRHDHERTSQSHDRRHERREETRGKRDREKDTREERESEHDHRDDREPRDSRDRRDTRD--R 480

  Fly   122 KKLVAKRN--------HIKRKLKEARLKKRAAAALSGHVHRSLSPTTRAKLKKLAERKRLRAAS- 177
            ::|...|:        ...|..||:|..:.:.:|...|.:|. .....|..:.:.:.:..|.|.
Mouse   481 RELRDSRDMRDSREMRDYSRDAKESRDPRDSRSARDVHDYRD-REARDAHARDVRDARDARDARD 544

  Fly   178 ----------------------------KEQRERDKLRVVQRDRE-------------------- 194
                                        ::.|:...:|.|:..|:
Mouse   545 ARDIRDVRDVRDVRDVRDVRDVRDVRDVRDVRDARDVRDVRDARDVRDVRDVRDGHRKEDVYQEE 609

  Fly   195 -----RDHHRLGSSRSPPSSSTTTTTKIRIHQDIVGK-RQKSPGL---GS-GLGGG---SSSSSS 246
                 |:|.|..|||....:.:...::..|..|.:|: |.:.|.|   || |..|.   |.||.|
Mouse   610 ARSYGRNHLREESSRVELRNDSRNESRSEIRNDRMGRSRGRGPELPEKGSRGTRGSQMDSHSSGS 674

  Fly   247 RMHHQLMSR---------------------------------------EKIIIQTRARGRTPSLE 272
            ..|....:|                                       ::.....|.:||:..||
Mouse   675 NYHDSWETRSSYPERDRYPERDTRDPARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRSEELE 739

  Fly   273 RERERERERERERERERHDLSLRERDRRDRERERAEREAARDKERAEALARCQERQRERERLARE 337
            |: ||..||..:|..||.|..:|:|| ||||||| |||..|::||        |::|||| |.||
Mouse   740 RD-ERREERRIDRVDERRDDRVRDRD-RDRERER-ERERERERER--------EKERERE-LERE 792

  Fly   338 KLRRQEEEEGGKRGGPGRDLDLPPYGSRERSLDTVERERERERSGRHVRDKRELDPYEREQEYLE 402
            :.|.:|.|                   ||:     ||||||||.    ||:|:.| ::||:|...
Mouse   793 RARERERE-------------------REK-----ERERERERE----RDQRDRD-HDRERERER 828

  Fly   403 ERHGHGLIDEMRRYRRRDLSPMPEHYAPRLRDPRELYSEEERERAYKRAYLDARYSSREREAWLE 467
            ||       |..:.|.|:            |:.||...|.||||            .||||
Mouse   829 ER-------EREKERERE------------REERERERERERER------------ERERE---- 858

  Fly   468 ARELRERELQGREYRDLETEDTLYPDERERLIRDRERDRERERDRERERNIGPRGDFRPEWEREW 532
                ||||                 .|||   |:|||:|.|||::||||            :|||
Mouse   859 ----RERE-----------------RERE---RERERERAREREKERER------------QREW 887

  Fly   533 EEEGAG--------------------------------GGPGGPSGTPGRPGGFVGGPKRGKPPA 565
            |::..|                                ...|.||  |.:      .|||.:  .
Mouse   888 EDKDKGRDDRREKREDIHVREDRIPRDSHEERKSKKRYRNEGSPS--PRQ------SPKRRR--E 942

  Fly   566 HAGGGPPSQQQHHSASEPD------------------------------WDADERERERE----- 595
            |:    |....:||..:.:                              |..::|:.||:
Mouse   943 HS----PDSDTYHSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKSERKESSRR 1003

  Fly   596 ------RER----DRERE------------------RDREDRPDTGGGGAGGDRPSIKNEPAWLE 632
                  :|:    ||:||                  |..|||...|...|
Mouse  1004 YEEQELKEKLSCGDRQREQAESVDSSRVRAQDLLSHRQAEDRDRDGSDRA--------------- 1053

  Fly   633 HDQREKPRG-----WQQQSSNSG---GDWRDNDDAPPAPSHPHPASPHHHVHPRGERGSGRGFRR 689
            ||:::|.:.     .:::..:.|   |:...::|:  ....|.......::..:.:|..|.....
Mouse  1054 HDEKKKAKAPKKPVKKKKEEDVGVERGNLETHEDS--QVFSPKKGQKKKNIEKKRKRSKGDSDVS 1116

  Fly   690 GGHGHGDHGERPGYRSHPPPLMTLPVQPPGGYSRGFPHKRLPYGSGRDG-----------AALGA 743
            .......:.::.|.|:  |||             ....:.....:.:||           |....
Mouse  1117 DEEAAPQNKKKRGPRT--PPL-------------AIKEELADISTDKDGVLEDPLKKENTAFSDW 1166

  Fly   744 RDGGLPGSSTFLKKHTHAPLVSPTQTPL-LNPLLNAAKPNAAAQASAVAAATTAVAAAKAAAQSA 807
            .|..:|..:..|:....|...:|..||. |:.||....|.|||..:|.|.|::||:|..:|..|:
Mouse  1167 SDEDVPDRTEGLEAEHTAATATPGSTPSPLSSLLPPPPPVAAASTAATALASSAVSATTSATSSS 1231

  Fly   808 ANATTNPG---------ILAQVSKLNTVCIKQEDA------------------------------ 833
            :.||:|..         ..|:..|:....:..||.
Mouse  1232 SAATSNTNGSEDSHRKCHRARGEKVEVSHVTLEDTPHRKLVDQKRSSSLGSNRSHRSHTSGRLRS 1296

  Fly   834 -SEDSA-------GTPE----LGAQD-SPTQSLNL----------------NQSLSSEGNPVKQE 869
             |.|||       |:.:    .|::| ..|:||.:                ::|.||:....:..
Mouse  1297 PSNDSAHRSGDDQGSRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSH 1361

  Fly   870 LIRTSAVEGELSEISDS---------------------------------------------DDD 889
            ..|.|:.|.:....|.|                                             |.|
Mouse  1362 SSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERDRRDPRQREWDREAEKEWPRTRDRD 1426

  Fly   890 ILNKTDKVRPKN---------------ELPTETEQEMDTN------ADEVKSEALHIVAGHPIKG 933
            .|.:.|:.|.:.               |...|.|:..:|:      ..|||.|:.|   ...::|
Mouse  1427 RLRERDRDRDRRRDLDRERERLISDPMERDRERERTFETSQLESGKRSEVKLESEH---ERDLEG 1488

  Fly   934 EEGDEV-LD-------------FEEISDGELEE-----------DARHKGIG------------- 960
            ...|.| ||             ||::|..|..|           ||...|.|
Mouse  1489 SSRDSVALDKERMDRDLGSVQGFEDVSKAERTESLEGDDESKLDDAHSLGSGAGEGYEPISDDEL 1553

  Fly   961 ------------------------DALGVDWQGLIAETRQQASDAQAAQQGVDRGTSAKQRWQPY 1001
                                    |.:.|||.||:.:..::..:..|          |..::.|.
Mouse  1554 DEILAGDAEKREDQQEEEKMPDPLDVIDVDWSGLMPKHPKEPREPGA----------ALLKFTPG 1608

  Fly  1002 RVLLDLGISFGMAG-EGYARCVMEEARQQLLQEKEQGQQRELDGDEEPPAKIPSPLLDYREFLAS 1065
            .|||.:|||..:|| |.:.:  ::|..|||:::.:       |.|.         |.::.
Mouse  1609 AVLLRVGISKKLAGSELFTK--VKETCQQLVEKPK-------DADS---------LFEHE----- 1650

  Fly  1066 QQQLEPLACVQMGLRSAAVERQRLVGNVCGPGSRALSARQDLRLRRQLC----GLPARECEFPRS 1126
                  |..:.|.......||..|:.:: ||..:||..|:|..:|:||.    |...:..   .:
Mouse  1651 ------LGALNMAALLRKEERASLLSDL-GPCCKALCFRRDSAIRKQLVKNEKGTVKQAY---TN 1705

  Fly  1127 VPIVGEGLRNLAMQMFQRR 1145
            .|:|...|..|::::|:::
Mouse  1706 TPMVDNELLRLSLRLFKKK 1724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
Flacc	NP_573339.1	None
Zc3h13	XP_036014719.1	zf-CCCH	42..63	CDD:395517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1874
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10758
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930