DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Flacc and zc3h13

DIOPT Version :9

Sequence 1:	NP_573339.1	Gene:	Flacc / 32886	FlyBaseID:	FBgn0030974	Length:	1150	Species:	Drosophila melanogaster
Sequence 2:	NP_956816.2	Gene:	zc3h13 / 560041	ZFINID:	ZDB-GENE-040426-1619	Length:	1759	Species:	Danio rerio

Alignment Length:	1656	Identity:	376/1656 - (22%)
Similarity:	541/1656 - (32%)	Gaps:	630/1656 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KAKESLRRYKKAARHSATHSSSSDSTS---DSDSGS-SSYSSTDSEQGVGGVGVGVGVPGGAGGP 64
            |.:|.:.:.:::...:.|.|||.|..|   .|..|| ||..|:.|.:..||.|   |.|......
Zfish   192 KREEIIIKKEESVSKTRTGSSSKDRASPEHTSSKGSPSSRKSSGSPKHRGGKG---GNPSKKEKK 253

  Fly    65 GGSGSVHGHP---HTHGHGHHPRSAERHHRKKKSSR-----------------------RGGSSS 103
            ..:.||...|   .|.......||::..|.|:|..|                       :....|
Zfish   254 SSTSSVISSPVSDQTRAEETDSRSSKSGHGKRKGPRTPSPPPPVPVENPVVGKKHKNKHKNKDKS 318

  Fly   104 GDEPSSSR-RKRDKRDHVQKKLVAK-RNHIKRKLKEARLKKRAAAALSGHVHRSLSPTTRAK--- 163
            .|:....: |.||...|.:||...: |:....|.|.:...:..:.:|| ...|..||..|.|
Zfish   319 EDKTKEGKERGRDAEKHKEKKEKRRDRSDSSHKAKRSMTSEERSGSLS-PPSREASPPARRKSSS 382

  Fly   164 ---LKKLAERKRLRAASKEQRERDKL------------RVVQRDRERDHHRLGSSRSPPSSSTTT 213
               ..|.|.:.|.|...:.:|.....            ...||......|| .||.:|.:|...|
Zfish   383 PKPSSKQASQHRSRTPPRHRRSTSPSSRQQQSPSSQSGSSAQRHSPSPRHR-RSSITPSASPPPT 446

  Fly   214 TTKIRIHQDIVGKRQKSPGLGSGLGGGSSSSSSRMHHQLMSREKIIIQTRARGRTPSLERERERE 278
            .:..|....|..:|..||.     .....||.|..|             |::||    |||||||
Zfish   447 QSSRRSRSSITPQRDPSPA-----SAPRRSSPSASH-------------RSQGR----ERERERE 489

  Fly   279 RERER------------ERERERHDLS----------------------------------LRER 297
            |:|:|            ||..||.|.|                                  ..||
Zfish   490 RDRDRGRAEQERSPAVQERRHERRDESRGKREKDSSRDERDYDIVQSSSREERDCRDSRDRRGER 554

  Fly   298 DRRD-RE-------------------RERAEREAARDKERAEALARCQERQRERERL---AREKL 339
            |||| ||                   |||:.||....:||.....|.:||:|||||.   .:|:.
Zfish   555 DRRDVREERQHRGDVKDTRDARAAETRERSGREPLEHRERDRDRERERERERERERTEMHRKEET 619

  Fly   340 RRQEE--------------------------EEGGKRGGPGRDLDLPPYGSR------------- 365
            ..|||                          |..|:..|.|.|:.....|||
Zfish   620 MTQEERSYGRGHGREDMRNDARTDNRNESRVERTGRGRGHGSDVTEKARGSRASQADNSSASGHD 684

  Fly   366 ---ERSLDTVERERER------------------ERSGRH-VRDKRELDPYEREQE----YLEER 404
               .||....||..||                  ||.|.| .||:|  |..||||.    ..::.
Zfish   685 SWESRSSGLRERSTERNTDRDRYDDRPRGEQPRDERRGAHNERDRR--DNREREQRAPSPVRQQN 747

  Fly   405 HGHGLIDEMRRYRRRDLSPMPEHYAPRLRDPRELYSEEERERAYKRAYLDARYSSREREAWLEAR 469
            .|..|..|.||..||: ....:....|.|: ||...:.||||..:|.....|...|||||..|..
Zfish   748 RGEDLEREERRDDRRN-DRGDDRRDDRTRE-REKERDREREREREREKEREREKEREREAERERE 810

  Fly   470 ELRERELQ---GREYRDLETEDTLYPDERERLIRDRERDRER-ERDRERERNIGPRGDFRPEWER 530
            ..||||.:   .||.|:.|.|:.    ||||..|:|||:||| ||:||||:.       ..|.:|
Zfish   811 RTREREREREREREEREREREER----EREREERERERERERKEREREREQR-------ERERQR 864

  Fly   531 EWEEEGAG-------------------------------GGPGGPSGTPGRPGGFVGGPKRGKPP 564
            ||:|...|                               .....||..|        .|||.:..
Zfish   865 EWDEREKGREERRERRDESREDRPPRDAHEDRKNIRKRHRAENTPSPRP--------SPKRARDV 921

  Fly   565 AHAGGGPPSQQQHHSASE-------------PDWDA--------DE---RERERERERDRERERD 605
            :     ||....::|..|             |...|        ||   |.::.:|..|::..|.
Zfish   922 S-----PPDSDGYNSTEEKSDKHRLLSQVVRPQETARSPVRSFTDEKHSRWKDEDRRVDKKDVRG 981

  Fly   606 REDRPDTGGGGAG---------------------------GDRPSIKNEPAWLE-------HDQR 636
            |.:..|:.|..||                           .|.||....|...|       |::.
Zfish   982 RHEEVDSRGERAGRAAERRGEHASDVSVTGVPESRRGKEQRDLPSTALTPPMEERDALSAVHEET 1046

  Fly   637 EKPRGWQQQSSN---------SGGDWRDND---------DAPPAPSHPHPASPHHHVHPRGERGS 683
            :|....|:::..         |||..|.|.         :||||...|........:..:.:|.
Zfish  1047 KKKTKTQKKNMKKNRKEDDGVSGGGDRSNPEPPISSTVAEAPPALLSPRKTPKKKALERKRKRS- 1110

  Fly   684 GRGFRRGGHGHGDHGE----------RPGYRSHPPPL---------------MTLPVQPPGGYS- 722
                 ||........|          |.|.|: |||:               .:|||:....:|
Zfish  1111 -----RGAESDVSEDELVTQQPLSKRRRGPRT-PPPINKDDLPSQRALTAGQSSLPVKLDANFSD 1169

  Fly   723 --------RG----------FPHKRLPYGSGRDGAALGARDGGLPGSSTFLKKHTHAPLVSPTQT 769
                    ||          .|.:|||   .|.||..|.||...|..:..|   ...|::  .|:
Zfish  1170 WSDEDVPERGETSTASMPSDRPPERLP---PRRGARGGGRDRTDPPIAPLL---PDPPML--MQS 1226

  Fly   770 PLLNPLL---NAAKPNAA----AQASAVAAATTAVAAA---KAAAQSAANATTNP-------GIL 817
            ..|.|||   ...||..|    .|.|:...:..:.|::   ::.:..:|:....|       |:|
Zfish  1227 LPLQPLLPQHMLRKPQQADMQQQQRSSSMGSNQSRASSRRLRSPSNESAHRDDGPQGMRSRRGLL 1291

  Fly   818 ----------------------------------------AQVSKL-------NTVCIKQEDASE 835
                                                    :::.:|       :|...:|:..|.
Zfish  1292 QGGNSRERDRERERERERERERDRDRERVVANEQMVGERKSRIDQLRRGEPSRSTSSDRQDSRSH 1356

  Fly   836 DS-AGTPE--------LGAQDS-----------------PTQSLNLNQSLSSE------------ 862
            .| ..:||        .|:.||                 ..:.|...||...|
Zfish  1357 SSRRSSPESERQARSRAGSYDSRERDRERDRDPLDREREKNRQLQNQQSQQREPEAREWGGRGRE 1421

  Fly   863 ----GN--PVKQELI------------------RTSAVEGELSEISDSD---------------- 887
                ||  |:::..:                  |.....||.....|.|
Zfish  1422 PLLRGNREPIRERDLREMRERERLLPEGLLAHERMDRERGERDRERDRDRMLPFDLQTHRDSKSR 1486

  Fly   888 ---------------DDILNKTDKVRPKNELPTET---------EQEMDTNADEVKSEALHIVAG 928
                           .::|...:|....:.|..|.         ::|.|..||:.:|    :|:|
Zfish  1487 AEMKMDRAEYEPLLPREVLKDVEKPADNSHLQGEASEPEKMDSLDEEEDGKADDAQS----VVSG 1547

  Fly   929 ----HPIKGEEGDEVLDFEEISDGELEEDARHKGIGDALGVDWQGLIAETRQQASDAQAAQQGVD 989
                .||..:|.||:|...:..| |.::|.:..|..|.:.|||..|:.:.:|:.....|
Zfish  1548 GEEYEPISDDELDEILADSQKRD-EQQDDEKTSGPLDVIDVDWSSLMPKQKQEPRTPGA------ 1605

  Fly   990 RGTSAKQRWQPYRVLLDLGISFGMAGEGYARCVMEEARQQLLQEKEQGQQRELDGDEEPPAKIPS 1054
                |..|:.|..|||..|:|..:||            .|||...::...||:   |:|  |...
Zfish  1606 ----ALLRFTPGAVLLRAGVSRRLAG------------PQLLARIKEVCAREI---EDP--KDAD 1649

  Fly  1055 PLLDYREFLASQQQLEPLACVQMGLRSAAVERQRLVGNVCGPGSRALSARQDLRLRRQLC----G 1115
            .||::           .|..:.|...:..:||..|:.:: ||..:||.||:|:.:||||.    |
Zfish  1650 KLLEH-----------DLGALNMAAYNRRMERASLLRSL-GPCCKALCARRDIAIRRQLLKNDKG 1702

  Fly  1116 LPARECEFPRSVPIVGEGLRNLAMQMFQRRL 1146
            ...   :...|.|:|...|..|::::|::::
Zfish  1703 TTK---QIYTSAPVVDNELVQLSLRLFKKKM 1730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
Flacc	NP_573339.1	None
zc3h13	NP_956816.2	zf-CCCH	49..69	CDD:279036
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3214
eggNOG	1	0.900	-	-		E1_KOG1874
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	190	1.000	Inparanoid score	I3875
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto39796
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10758
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.980